알프레드 G. 길먼

위키百科, 우리 모두의 百科事典.

알프레드 G. 길먼
Alfred G. Gilman
1994년 촬영
1994年 撮影
出生 1941年 7月 1日 ( 1941-07-01 )
美國 코네티컷주 뉴헤이븐
死亡 2015年 12月 23日 ( 2015-12-23 ) (74歲)
美國 텍사스州 댈러스
國籍 美國
主要 業績 G蛋白質
受賞 John J. Abel Award(1975年)
리처드 런즈베리賞(1987年)
루이자 그로스 호르위츠上 (1989年)
노벨 生理學·醫學賞 (1994年)
分野 生化學 , 藥理學

알프레드 굿맨 길먼 ( 英語 : Alfred Goodman Gilman , 1941年 7月 1日 ~ 2015年 12月 23日 )은 美國 의 生化學 者, 藥理學 者 [1] 이다. 1994年에 細胞膜에 存在하는 G蛋白質 을 發見한 功勞로 마틴 로드벨 과 함께 노벨 生理學·醫學賞 을 受賞했다. [2]

受賞 經歷 [ 編輯 ]

主要 論文 [ 編輯 ]

  • Seeds, NW; Gilman, AG (1971). “Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures”. 《Science》 174 (4006): 292. doi : 10.1126/science.174.4006.292 . PMID   4330303 .  
  • Gilman, AG; Nirenberg, M (1971). “Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells”. 《Nature》 234 (5328): 356?8. doi : 10.1038/234356a0 . PMID   4332686 .  
  • Secrist JA, 3rd; Barrio, JR; Leonard, NJ; Villar-Palasi, C; Gilman, AG (1972). “Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems”. 《Science》 177 (4045): 279?80. doi : 10.1126/science.177.4045.279 . PMID   4339302 .  
  • Sternweis, PC; Northup, JK; Smigel, MD; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties”. 《The Journal of Biological Chemistry》 256 (22): 11517?26. PMID   6271754 .  
  • Hanski, E; Sternweis, PC; Northup, JK; Dromerick, AW; Gilman, AG (1981). “The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein”. 《The Journal of Biological Chemistry》 256 (24): 12911?9. PMID   6273414 .  
  • Schleifer, LS; Kahn, RA; Hanski, E; Northup, JK; Sternweis, PC; Gilman, AG (1982). “Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase”. 《The Journal of Biological Chemistry》 257 (1): 20?3. PMID   6273425 .  
  • Northup, JK; Smigel, MD; Gilman, AG (1982). “The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding”. 《The Journal of Biological Chemistry》 257 (19): 11416?23. PMID   6288684 .  
  • Manning, DR; Gilman, AG (1983). “The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins”. 《The Journal of Biological Chemistry》 258 (11): 7059?63. PMID   6304074 .  
  • Northup, JK; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11361?8. PMID   6309843 .  
  • Northup, JK; Smigel, MD; Sternweis, PC; Gilman, AG (1983). “The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit”. 《The Journal of Biological Chemistry》 258 (18): 11369?76. PMID   6309844 .  
  • Hurley, JB; Simon, MI; Teplow, DB; Robishaw, JD; Gilman, AG (1984). “Homologies between signal transducing G proteins and ras gene products”. 《Science》 226 (4676): 860?2. doi : 10.1126/science.6436980 . PMID   6436980 .  
  • Gilman, AG (1984). “G proteins and dual control of adenylate cyclase”. 《Cell》 36 (3): 577?9. doi : 10.1016/0092-8674(84)90336-2 . PMID   6321035 .  
  • Bokoch, GM; Gilman, AG (1984). “Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin”. 《Cell》 39 (2 Pt 1): 301?8. doi : 10.1016/0092-8674(84)90008-4 . PMID   6094010 .  
  • Harris, BA; Robishaw, JD; Mumby, SM; Gilman, AG (1985). “Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase”. 《Science》 229 (4719): 1274?7. doi : 10.1126/science.3839937 . PMID   3839937 .  
  • Mattera, R; Graziano, MP; Yatani, A; Zhou, Z; Graf, R; Codina, J; Birnbaumer, L; Gilman, AG; Brown, AM (1989). “Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. 《Science》 243 (4892): 804?7. doi : 10.1126/science.2536957 . PMID   2536957 .  
  • Krupinski, J; Coussen, F; Bakalyar, HA; Tang, WJ; Feinstein, PG; Orth, K; Slaughter, C; Reed, RR; Gilman, AG (1989). “Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure”. 《Science》 244 (4912): 1558?64. doi : 10.1126/science.2472670 . PMID   2472670 .  
  • Tang, WJ; Gilman, AG (1991). “Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits”. 《Science》 254 (5037): 1500?3. doi : 10.1126/science.1962211 . PMID   1962211 .  
  • Taussig, R; Iniguez-Lluhi, JA; Gilman, AG (1993). “Inhibition of adenylyl cyclase by Gi alpha”. 《Science》 261 (5118): 218?21. doi : 10.1126/science.8327893 . PMID   8327893 .  
  • Wickman, KD; Iniguez-Lluhl, JA; Davenport, PA; Taussig, R; Krapivinsky, GB; Linder, ME; Gilman, AG; Clapham, DE (1994). “Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel”. 《Nature》 368 (6468): 255?7. doi : 10.1038/368255a0 . PMID   8145826 .  
  • Coleman, D.; Berghuis, A.; Lee, E; Linder, M.; Gilman, A.; Sprang (1994). “Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis”. 《Science》 265 (5177): 1405?1412. doi : 10.1126/science.8073283 . PMID   8073283 .  
  • Tang, WJ; Gilman, AG (1995). “Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin”. 《Science》 268 (5218): 1769?72. doi : 10.1126/science.7792604 . PMID   7792604 .  
  • Mixon, MB; Lee, E; Coleman, DE; Berghuis, AM; Gilman, AG; Sprang, SR (1995). “Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis”. 《Science》 270 (5238): 954?60. doi : 10.1126/science.270.5238.954 . PMID   7481799 .  
  • Wall, MA; Coleman, DE; Lee, E; Iniguez-Lluhi, JA; Posner, BA; Gilman, AG; Sprang, SR (1995). “The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2”. 《Cell》 83 (6): 1047?58. doi : 10.1016/0092-8674(95)90220-1 . PMID   8521505 .  
  • Berman, David M; Wilkie, Thomas M; Gilman, Alfred G (1996). “GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits”. 《Cell》 86 (3): 445?452. doi : 10.1016/S0092-8674(00)80117-8 . PMID   8756726 .  
  • Sunahara, RK; Tesmer, JJ; Gilman, AG; Sprang, SR (1997). “Crystal structure of the adenylyl cyclase activator Gsalpha”. 《Science》 278 (5345): 1943?7. doi : 10.1126/science.278.5345.1943 . PMID   9395396 .  
  • Tesmer, JJ; Sunahara, RK; Gilman, AG; Sprang, SR (1997). “Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS”. 《Science》 278 (5345): 1907?16. doi : 10.1126/science.278.5345.1907 . PMID   9417641 .  

參考 文獻 [ 編輯 ]

各州 [ 編輯 ]

  1. ↑ Lefkowitz, Robert J. (2016). “Alfred Goodman Gilman (1941?2015)”. 《Nature》 529 (7586): 284?284. doi : 10.1038/529284a .  
  2. ↑ “The Nobel Prize in Physiology or Medicine 1994” . Nobel Media AB . 2016年 1月 22日에 確認함 .  

外部 링크 [ 編輯 ]

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