rVSV-ZEBOV
全名
重組水泡性口炎病毒-薩伊伊波拉病毒
(Recombinant vesicular stomatitis virus?Zaire Ebola virus),又稱
伊波拉病毒活毒疫苗
(Ebola Zaire vaccine live),
商品名
?
Ervebo
,是抗
薩伊伊波拉病毒
、避免人類
伊波拉出血熱
的
疫苗
[3]
[4]
[5]
[6]
,在疫區對人群進行
?形免疫接?
可有效緩解疫情
[7]
[8]
[9]
。此疫苗?一
重組
病毒載體疫苗
[10]
,成分?經基因重組、表現薩伊伊波拉病毒
?蛋白
的
水泡性口炎病毒
顆粒,因而可刺激人體?生對抗伊波拉病毒的
免疫反應
[3]
[11]
。
此疫苗最初由
加拿大國家微生物實驗室
?究團隊開發,於2003年申請專利
[12]
[13]
,2010年授權小型製藥公司Newlink Genetics繼續?發,2014年後者又將專利?予
默克藥廠
[14]
。2019年此疫苗獲美國與歐盟批准使用
[4]
[15]
[11]
[16]
。
2018年剛果赤道省伊波拉出血熱爆發
中此疫苗首次被用於控制伊波拉疫情
[17]
,不久後又在
該國基伍地區的嚴重疫情
中被大量使用
[9]
。
約有半數此疫苗的施打者出現輕度至中度的副作用,包括頭痛、疲倦、肌肉?痛等
[7]
。
參考文獻
[
??
]
- ^
Monath TP, Fast PE, Modjarrad K, et al.
rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment
. Vaccine: X. April 2019,
1
. 100009.
PMC 6668225
.
PMID 31384731
.
doi:10.1016/j.jvacx.2019.100009
.
- ^
Ebola Vaccine: Information about Ervebo
.
Centers for Disease Control and Prevention
(CDC). February 26, 2020
[
April 16,
2021]
. (原始?容
存?
于2021-04-16).
- ^
3.0
3.1
3.2
Ervebo (Ebola Zaire Vaccine, Live) Suspension for intramuscular injection
(PDF)
. Merck Sharp & Dohme.
[
2022-11-06
]
. (原始?容
存?
于2020-03-29).
- ^
4.0
4.1
4.2
Ervebo EPAR
.
European Medicines Agency
(EMA). October 16, 2019
[
March 29,
2020]
. (原始?容
存?
于2021-03-08).
- ^
Trad MA, Naughton W, Yeung A, et al.
Ebola virus disease: An update on current prevention and management strategies
. Journal of Clinical Virology. January 2017,
86
: 5?13.
PMID 27893999
.
doi:10.1016/j.jcv.2016.11.005
.
hdl:10144/618818
.
- ^
Pavot V. Ebola virus vaccines: Where do we stand?. Clinical Immunology. December 2016,
173
: 44?49.
PMID 27910805
.
doi:10.1016/j.clim.2016.10.016
.
- ^
7.0
7.1
Medaglini, D; Siegrist, CA.
Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine.
. Current Opinion in Virology. April 2017,
23
: 88?94.
PMID 28460340
.
doi:10.1016/j.coviro.2017.03.008
.
- ^
Mole, Beth.
As Ebola outbreak rages, vaccine is 97.5% effective, protecting over 90K people
. Ars Technica. April 16, 2019
[
April 17,
2019]
. (原始?容
存?
于2021-02-19).
- ^
9.0
9.1
Ebola Ring Vaccination Results April 12, 2019
.
World Health Organization
(WHO) (?告). April 12, 2019
[
April 17,
2019]
. (原始?容
存?
于2022-11-06).
- ^
Marzi, Andrea; et al.
Vesicular Stomatitis Virus?Based Ebola Vaccines With Improved Cross-Protective Efficacy
. Journal of Infectious Diseases. November 2011,
204
(suppl 3): S1066?S1074.
PMC 3203393
.
PMID 21987743
.
doi:10.1093/infdis/jir348
.
- ^
11.0
11.1
Choi MJ, Cossaboom CM, Whitesell AN, Dyal JW, Joyce A, Morgan RL, et al.
Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020
(PDF)
. MMWR Recommendations and Reports. January 2021,
70
(1): 1?12
[
2022-11-06
]
.
PMC 7802368
.
PMID 33417593
.
doi:10.15585/mmwr.rr7001a1
. (原始?容
存?
(PDF)
于2021-03-20).
- ^
Grady, Denise.
Ebola Vaccine, Ready for Test, Sat on the Shelf
.
The New York Times
. October 23, 2014
[
December 21,
2019]
. (原始?容
存?
于2020-06-14).
- ^
Jones SM, Feldmann H, Stroher U, Geisbert JB, Fernando L, Grolla A, et al. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses.
Nature Medicine
. July 2005,
11
(7): 786?90.
PMID 15937495
.
S2CID 5450135
.
doi:10.1038/nm1258
.
- ^
Merck & Co. Licenses NewLink's Ebola Vaccine Candidate
. Genetic Engineering & Biotechnology News. November 24, 2014
[
January 20,
2016]
. (
原始?容
存?于May 18, 2018).
- ^
First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health preparedness and response
. U.S.
Food and Drug Administration
(FDA) (新?稿). December 19, 2019
[
December 19,
2019]
. (原始?容
存?
于December 20, 2019).
- ^
Ervebo
. U.S.
Food and Drug Administration
(FDA). December 19, 2019
[
March 28,
2020]
. STN: 125690. (原始?容
存?
于2020-04-29).
- ^
McKenzie, David.
Fear and failure: How Ebola sparked a global health revolution
.
CNN
. May 26, 2018
[
May 26,
2018]
. (原始?容
存?
于2019-08-26).
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默克集團
(?同一家德?公司分?的???立公司) ·
先??雅
(2009年被收?成?子公司)
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