????
|
臨床資料
|
---|
ATC碼
| |
---|
??信息
|
---|
(6
R
,7
R
)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-([2-(trifluoromethylsulfanyl)acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
|
CAS?
| 58665-96-6
52123-49-6
Y
|
---|
PubChem
CID
| |
---|
ChemSpider
| |
---|
UNII
| |
---|
KEGG
| |
---|
ChEMBL
| |
---|
CompTox Dashboard
(
EPA
)
| |
---|
化?信息
|
---|
化?式
| C
13
H
13
F
3
N
6
O
4
S
3
|
---|
摩??量
| 470.46 g·mol
?1
|
---|
3D模型(
JSmol
)
| |
---|
O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)CSC(F)(F)F)CSc3nnnn3C)C(=O)O
|
InChI=1S/C13H13F3N6O4S3/c1-21-12(18-19-20-21)28-3-5-2-27-10-7(9(24)22(10)8(5)11(25)26)17-6(23)4-29-13(14,15)16/h7,10H,2-4H2,1H3,(H,17,23)(H,25,26)/t7-,10-/m1/s1
Key:HGXLJRWXCXSEJO-GMSGAONNSA-N
|
????
(
INN
:Cefazaflur)是第一代
??菌素
?抗生素。
合成
[
??
]
????在???似物中??而出,因??缺乏芳??C-7??(?一?例子??
??乙?
)。
????是通?
3-(1-甲基-1
H
-四?-5-基硫代?甲基)-7-?基-???-4-甲酸
(
1
)?
三?甲硫基乙??
(
2
)反?合成的。
?考?料
[
??
]
- ^
DeMarinis RM, Boehm JC, Dunn GL, Hoover JR, Uri JV, Guarini JR, et al. Semisynthetic cephalosporins. Synthesis and structure-activity relationships of analogues with 7-acyl groups derived from 2-(cyanomethylthio)acetic acid or 2-[(2,2,2-trifluoroethyl)thio]acetic acid and their sulfoxides and sulfones. Journal of Medicinal Chemistry. January 1977,
20
(1): 30?5.
PMID 319233
.
doi:10.1021/jm00211a006
.