Randy Schekman

Randy Schekman
Randy Schekman
	Randy Schekman, 2015
Narozeni	30. prosince 1948 (75 let) ; Saint Paul
Alma mater	Edinburska univerzita ; Stanfordova univerzita ; UCLA
Povolani	biochemik, leka? , vysoko?kolsky u?itel a biolog
Zam?stnavatele	Kalifornska univerzita v Berkeley ; Howard Hughes Medical Institute ; Stanford University ; UCLA
Ocen?ni	Cena Alberta Laskera (2002) ; Massryho cena (2010) ; zahrani?ni ?len Kralovske spole?nosti (2013) ; Nobelova cena (2013)
Web	mcb.berkeley.edu/labs/schekman
	multimedialni obsah na Commons
	N?ktera data mohou pochazet z datove polo?ky .

Randy Wayne Schekman (* 30. prosince 1948 Saint Paul , Minnesota ) je americky bun??ny biolog a biochemik na Kalifornske univerzit? v Berkeley ^[2] a v obdobi 2006?2011 ?efredaktor Proceedings of the National Academy of Sciences , oficialniho ?asopisu Narodni akademie v?d . ^[3]^[4]^[5] V roce 2011 bylo uvedeno, ?e se stane editorem otev?eneho ?asopisu eLife , vydavaneho od roku 2012 Leka?skym institutem Howarda Hughese, Spole?nosti Maxe Plancka a trustem Wellcome. ^[6]

Roku 1992 byl zvolen ?lenem Narodni akademie v?d. ^[7] V roce 1999 pak zastaval funkci prezidenta Americke spole?nosti pro bun??nou biologii. Spole?n? s Jamesem Rothmannem obdr?el roku 2002 Laskerovu cenu. Op?t s Rothmanem a take s Thomasem Sudhofem se v roce 2013 stal laureatem Nobelovy ceny za fyziologii nebo leka?stvi , kdy? byl ocen?n jejich p?inos na poli poznani mechanizmu regulace vezikularniho transportu. ^[8]^[9]^[10]

Vzd?lani [ editovat | editovat zdroj ]

Bakala?sky stupe? vysoko?kolskeho vzd?lani ziskal v roce 1971 na Kalifornske univerzit? v Los Angeles v oboru molekularni biologie (B.A.). T?eti ro?nik stravil na studijnim vym?nnem pobytu na skotske Univerzit? v Edinburghu . ^[11]^[12]

Postgradualni studium biochemie dokon?il roku 1974 na Stanfordov? univerzit? ( Ph.D. ), kdy? se pod vedenim nositele Nobelovy ceny Arthura Kornberga zabyval vyzkumem replikace DNA . ^[13]

V?decka ?innost [ editovat | editovat zdroj ]

V letech 1974?1976 stravil postdoktoralni pobyt v laborato?i Kalifornske univerzity v San Diegu , ktera se soust?edila na bun??nou membranu v sav?ich bu?kach. Od roku 1976 p?sobi na Kalifornske univerzity v Berkeley , konkretn? pracuje v Ustavu molekularni a bun??ne biologie Biochemicke sekce univerzity v Berkeley (Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology at the University of California, Berkeley). Ve sve laborato?i provadi vyzkum membranovych proces? na molekularni urovni a v?nuje se take vezikularnimu transportu ^[14] v eukaryotickych bu?kach ^[15]^[16] a u jednobun??nych mikroorganism? kvasinek . ^[17] D?ive take na Kalifornske univerzit? p?edna?el. V roce 1984 se habilitoval a o p?t let pozd?ji ziskal ?adnou profesuru v oborech molekularni a bun??na biologie .

Od roku 1991 je take ?lenem Leka?skeho institutu Howarda Hughese (Howard Hughes Medical Institute) v marylandskem Chevy Chase ^[18]

Vyb?r ocen?ni [ editovat | editovat zdroj ]

1987: Cena Eliho Lilly v mikrobiologii a imunologii
1992: ?len Narodni akademie v?d Spojenych stat? americkych
1994: Gairdner Foundation International Award
1994: Rosenstielova cena
2000: ?len American Academy of Arts and Sciences
2002: Cena Alberta Laskera za zakladni vyzkum v leka?stvi (spoludr?itel James Rothman ) ^[19]
2002: Cena Louisy Gross Horwitzove (spoludr?itel James Rothman)
2005: Keith R. Porter Lecture
2008: Dicksonova cena v leka?stvi ^[20]
2010: Massryho cena ^[21]
2010: Medaile E. B. Wilsona
2013: zahrani?ni ?len Kralovske spole?nosti ^[22]
2013: Medaile Otto Warburga
2013: Nobelova cena za fyziologii nebo leka?stvi (spoludr?itele Thomas Sudhof a James Rothman )

Odkazy [ editovat | editovat zdroj ]

Reference [ editovat | editovat zdroj ]

V tomto ?lanku byly pou?ity p?eklady text? z ?lank? Randy Schekman na anglicke Wikipedii a Randy Schekman na n?mecke Wikipedii.

↑ Professor Randy Schekman ForMemRS [online]. Royalsociety.org [cit. 2013-10-07]. Dostupne v archivu po?izenem dne 2018-12-25.
↑ Randy Schekman: Howard Hughes Investigator and Professor of Cell and Developmental Biology [online]. [cit. 2011-07-12]. Dostupne online .
↑ ZAGORSKI, Nick. Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief [online]. Proceedings of the National Academy of Sciences, 2008 [cit. 2013-10-10]. S. 105 (8): 2763?2765. Dostupne online . (anglicky)
↑ BUCCI, M. Randy Schekman [online]. Nature Chemical Biology, 2006 [cit. 2013-10-10]. S. 2 (11): 568. Dostupne online . (anglicky)
↑ ZAGORSKI, Nick. QnAs with Randy Schekman [online]. Proceedings of the National Academy of Sciences, 2006 [cit. 2013-10-10]. S. 103 (50): 18881. Dostupne online . (anglicky)
↑ New journal editor named as Randy Schekman | Wellcome Trust [online]. [cit. 2011-07-12]. Dostupne online .
↑ Randy Schekman, Profile [online]. Microsoft Academic Search, 2006 [cit. 2013-10-10]. Dostupne v archivu po?izenem dne 2013-12-05. (anglicky)
↑ ALTMAN, Lawrence. 3 Win Joint Nobel Prize in Medicine [online]. NY Times, 7 October 2013 [cit. 2013-10-07]. Dostupne online .
↑ James E. Rothman, Ph.D. ’76, Shares Nobel Prize for Medicine [online]. Harvard Magazine, 7 October 2013 [cit. 2013-10-07]. Dostupne online .
↑ The Nobel Prize in Physiology or Medicine 2013 [online]. Nobel Prize [cit. 2013-10-07]. Dostupne online .
↑ Randy Schekman, molecular biologist and UCLA alumnus, wins 2013 Nobel Prize [online]. University of California, Los Angeles [cit. 2013-10-08]. Dostupne online .
↑ Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief [online]. National Academy of Sciences [cit. 2013-10-08]. Dostupne online .
↑ SCHEKMAN, Randy Wayne. Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) [online]. Stanford University, 1975. Dostupne online .
↑ SCHECKMAN, Randy; ORCI, Lelio. Coat Proteins and Vesicle Budding [online]. Science, 1996 [cit. 2013-10-10]. S. 271 (5255): 1526?1533.. Dostupne online . (anglicky)
↑ Randy Schekman publications in Google Scholar [online]. [cit. 2011-07-12]. Dostupne online .
↑ SCHECKMAN, R.; DESHAIES, R. J.; KOCH, B. D.; WERNER-WASHBURNE, M.; CRAIG, E. A. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides [online]. Nature, 1988 [cit. 2013-10-10]. S. 332 (6167): 800?805.. Dostupne online . (anglicky)
↑ SCHECKMAN, R.; NOVICK, P.; FIELD, C. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway [online]. Cell, August 1980 [cit. 2013-10-10]. S. 21 (1): 205?215. Dostupne online . (anglicky)
↑ HHMI Scientist Abstract: Randy W. Schekman, Ph.D. [online]. [cit. 2011-07-12]. Dostupne online .
↑ James Rothman and Randy Schekman Archivovano 16. 7. 2010 na Wayback Machine . bei laskerfoundation.org; abgerufen am 31. Oktober 2010
↑ 2008 Dickson Prize Winner bei pitt.edu; abgerufen am 3. November 2010
↑ usc.edu Archivovano 26. 11. 2010 na Wayback Machine .; abgerufen am 6. November 2010
↑ New Fellows 2013 der Royal Society (royalsociety.org); abgerufen am 7. Mai 2013

Externi odkazy [ editovat | editovat zdroj ]

Obrazky, zvuky ?i videa k tematu Randy Schekman na Wikimedia Commons
(anglicky) Randy Schekman na Howard Hughes Medical Institute

P?edch?dce	Randy Schekman	Nastupce
Elizabeth Blackburnova	prezident Americke spole?nosti pro bun??nou biologii 1999	Richard Hynes
Nicholas R. Cozzarelli	?efredaktor PNAS 2006?2011	Inder Verma
?	?efredaktor eLife 2012?

[formemrs-1] Professor Randy Schekman ForMemRS [online]. Royalsociety.org [cit. 2013-10-07]. Dostupne v archivu po?izenem dne 2018-12-25.

[2] Randy Schekman: Howard Hughes Investigator and Professor of Cell and Developmental Biology [online]. [cit. 2011-07-12]. Dostupne online .

[pnas-3] ZAGORSKI, Nick. Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief [online]. Proceedings of the National Academy of Sciences, 2008 [cit. 2013-10-10]. S. 105 (8): 2763?2765. Dostupne online . (anglicky)

[4] BUCCI, M. Randy Schekman [online]. Nature Chemical Biology, 2006 [cit. 2013-10-10]. S. 2 (11): 568. Dostupne online . (anglicky)

[5] ZAGORSKI, Nick. QnAs with Randy Schekman [online]. Proceedings of the National Academy of Sciences, 2006 [cit. 2013-10-10]. S. 103 (50): 18881. Dostupne online . (anglicky)

[6] New journal editor named as Randy Schekman | Wellcome Trust [online]. [cit. 2011-07-12]. Dostupne online .

[microsoft-7] Randy Schekman, Profile [online]. Microsoft Academic Search, 2006 [cit. 2013-10-10]. Dostupne v archivu po?izenem dne 2013-12-05. (anglicky)

[NY_times_Nobel_article-8] ALTMAN, Lawrence. 3 Win Joint Nobel Prize in Medicine [online]. NY Times, 7 October 2013 [cit. 2013-10-07]. Dostupne online .

[9] James E. Rothman, Ph.D. ’76, Shares Nobel Prize for Medicine [online]. Harvard Magazine, 7 October 2013 [cit. 2013-10-07]. Dostupne online .

[10] The Nobel Prize in Physiology or Medicine 2013 [online]. Nobel Prize [cit. 2013-10-07]. Dostupne online .

[11] Randy Schekman, molecular biologist and UCLA alumnus, wins 2013 Nobel Prize [online]. University of California, Los Angeles [cit. 2013-10-08]. Dostupne online .

[12] Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief [online]. National Academy of Sciences [cit. 2013-10-08]. Dostupne online .

[schekphd-13] SCHEKMAN, Randy Wayne. Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) [online]. Stanford University, 1975. Dostupne online .

[14] SCHECKMAN, Randy; ORCI, Lelio. Coat Proteins and Vesicle Budding [online]. Science, 1996 [cit. 2013-10-10]. S. 271 (5255): 1526?1533.. Dostupne online . (anglicky)

[15] Randy Schekman publications in Google Scholar [online]. [cit. 2011-07-12]. Dostupne online .

[16] SCHECKMAN, R.; DESHAIES, R. J.; KOCH, B. D.; WERNER-WASHBURNE, M.; CRAIG, E. A. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides [online]. Nature, 1988 [cit. 2013-10-10]. S. 332 (6167): 800?805.. Dostupne online . (anglicky)

[17] SCHECKMAN, R.; NOVICK, P.; FIELD, C. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway [online]. Cell, August 1980 [cit. 2013-10-10]. S. 21 (1): 205?215. Dostupne online . (anglicky)

[18] HHMI Scientist Abstract: Randy W. Schekman, Ph.D. [online]. [cit. 2011-07-12]. Dostupne online .

[19] James Rothman and Randy Schekman Archivovano 16. 7. 2010 na Wayback Machine . bei laskerfoundation.org; abgerufen am 31. Oktober 2010

[20] 2008 Dickson Prize Winner bei pitt.edu; abgerufen am 3. November 2010

[21] usc.edu Archivovano 26. 11. 2010 na Wayback Machine .; abgerufen am 6. November 2010

[22] New Fellows 2013 der Royal Society (royalsociety.org); abgerufen am 7. Mai 2013

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Nositele Nobelovy ceny za fyziologii a leka?stvi

1901?1925	Emil von Behring (1901) Ronald Ross (1902) Niels Ryberg Finsen (1903) Ivan Petrovi? Pavlov (1904) Robert Koch (1905) Camillo Golgi / Santiago Ramon y Cajal (1906) Alphonse Laveran (1907) Ilja Ilji? Me?nikov / Paul Ehrlich (1908) Emil Theodor Kocher (1909) Albrecht Kossel (1910) Allvar Gullstrand (1911) Alexis Carrel (1912) Charles Richet (1913) Robert Barany (1914) Jules Bordet (1919) August Krogh (1920) Archibald Hill / Otto Fritz Meyerhof (1922) Frederick Banting / John James Rickard Macleod (1923) Willem Einthoven (1924)

1926?1950	Johannes Fibiger (1926) Julius Wagner-Jauregg (1927) Charles Nicolle (1928) Christiaan Eijkman / Frederick Hopkins (1929) Karl Landsteiner (1930) Otto Heinrich Warburg (1931) Charles Scott Sherrington / Edgar Douglas Adrian (1932) Thomas Morgan (1933) George Whipple / George Richards Minot / William Parry Murphy (1934) Hans Spemann (1935) Henry Hallett Dale / Otto Loewi (1936) Albert Szent-Gyorgyi (1937) Corneille Heymans (1938) Gerhard Domagk (1939) Henrik Dam / Edward Adelbert Doisy (1943) Joseph Erlanger / Herbert Spencer Gasser (1944) Alexander Fleming / Ernst Boris Chain / Howard Walter Florey (1945) Hermann Joseph Muller (1946) Carl Ferdinand Cori / Gerty Coriova / Bernardo Houssay (1947) Paul Hermann Muller (1948) Walter Rudolf Hess / Antonio Egas Moniz (1949) Philip Showalter Hench / Edward Calvin Kendall / Tadeus Reichstein (1950)

1951?1975	Max Theiler (1951) Selman Abraham Waksman (1952) Hans Adolf Krebs / Fritz Albert Lipmann (1953) John Franklin Enders / Frederick Chapman Robbins / Thomas Huckle Weller (1954) Hugo Theorell (1955) Andre Frederic Cournand / Werner Forßmann / Dickinson W. Richards (1956) Daniel Bovet (1957) George Wells Beadle / Edward Lawrie Tatum / Joshua Lederberg (1958) Arthur Kornberg / Severo Ochoa (1959) Frank Macfarlane Burnet / Peter Brian Medawar (1960) Georg von Bekesy (1961) Francis Crick / James Dewey Watson / Maurice Wilkins (1962) John Carew Eccles / Alan Lloyd Hodgkin / Andrew Fielding Huxley (1963) Konrad Bloch / Feodor Lynen (1964) Francois Jacob / Andre Lwoff / Jacques Monod (1965) Francis Peyton Rous / Charles Brenton Huggins (1966) Ragnar Granit / Haldan Keffer Hartline / George Wald (1967) Robert W. Holley / Har Gobind Khorana / Marshall Warren Nirenberg (1968) Max Delbruck / Alfred Hershey / Salvador Luria (1969) Julius Axelrod / Ulf von Euler / Bernard Katz (1970) Earl Wilbur Sutherland (1971) Gerald Edelman / Rodney Robert Porter (1972) Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen (1973) Albert Claude / Christian de Duve / George Emil Palade (1974) David Baltimore / Renato Dulbecco / Howard Martin Temin (1975)

1976?2000	Baruch Samuel Blumberg / Daniel Carleton Gajdusek (1976) Roger Guillemin / Andrew Schally / Rosalyn Yalowova (1977) Werner Arber / Daniel Nathans / Hamilton O. Smith (1978) Allan McLeod Cormack / Godfrey N. Hounsfield (1979) Baruj Benacerraf / Jean Dausset / George Davis Snell (1980) Roger W. Sperry / David H. Hubel / Torsten Wiesel (1981) Sune Bergstrom / Bengt Samuelsson / John Vane (1982) Barbara McClintockova (1983) Niels Kaj Jerne / Georges Kohler / Cesar Milstein (1984) Michael S. Brown / Joseph L. Goldstein (1985) Stanley Cohen / Rita Leviova-Montalciniova (1986) Susumu Tonegawa (1987) James W. Black / Gertrude Belle Elionova / George H. Hitchings (1988) J. Michael Bishop / Harold E. Varmus (1989) Joseph Murray / E. Donnall Thomas (1990) Erwin Neher / Bert Sakmann (1991) Edmond H. Fischer / Edwin G. Krebs (1992) Richard John Roberts / Phillip A. Sharp (1993) Alfred G. Gilman / Martin Rodbell (1994) Edward B. Lewis / Christiane Nussleinova-Volhardova / Eric F. Wieschaus (1995) Peter C. Doherty / Rolf Martin Zinkernagel (1996) Stanley B. Prusiner (1997) Robert F. Furchgott / Louis Ignarro / Ferid Murad (1998) Gunter Blobel (1999) Arvid Carlsson / Paul Greengard / Eric Kandel (2000)

2001?	Leland H. Hartwell / Tim Hunt / Paul Nurse (2001) Sydney Brenner / H. Robert Horvitz / John Sulston (2002) Paul Lauterbur / Peter Mansfield (2003) Richard Axel / Linda B. Buckova (2004) Barry Marshall / Robin Warren (2005) Andrew Z. Fire / Craig C. Mello (2006) Mario Capecchi / Martin Evans / Oliver Smithies (2007) Harald zur Hausen / Francoise Barre-Sinoussi / Luc Montagnier (2008) Elizabeth Blackburnova / Carol W. Greiderova / Jack W. Szostak (2009) Robert G. Edwards (2010) Bruce Beutler / Jules A. Hoffmann / Ralph M. Steinman (2011) John Gurdon / ?in’ja Jamanaka (2012) James Rothman / Randy Schekman / Thomas Sudhof (2013) John O'Keefe / May-Britt Moserova / Edvard Moser (2014) William C. Campbell / Sato?i Omura / Tchu Jou-jou (2015) Jo?inori Osumi (2016) Jeffrey C. Hall / Michael Rosbash / Michael W. Young (2017) James P. Allison / Tasuku Hond?o (2018) Gregg L. Semenza / Peter J. Ratcliffe / William Kaelin (2019) Harvey J. Alter / Michael Houghton / Charles M. Rice (2020) David Julius / Ardem Patapoutian (2021) Svante Paabo (2022) Katalin Karikoova / Drew Weissman (2023)