Vaccine which prevents mumps
Mumps vaccines
are
vaccines
which prevent
mumps
.
[1]
When given to a majority of the population they decrease complications at the
population
level.
[1]
Effectiveness when 90% of a population is vaccinated is estimated at 85%.
[2]
Two doses are required for long term prevention.
[1]
The initial dose is recommended between 12 and 18 months of age.
[1]
The second dose is then typically given between two years and six years of age.
[1]
Usage after exposure in those not already
immune
may be useful.
[3]
Side effects are generally mild.
[1]
[3]
It may cause mild pain and swelling at the site of injection and mild fever.
[1]
More significant side effects are rare.
[1]
Evidence is insufficient to link the vaccine to complications such as neurological effects.
[3]
The vaccine should not be given to people who are
pregnant
or have very
poor immune system function
.
[1]
Poor outcomes among children of mothers who received the vaccine during pregnancy, however, have not been documented.
[1]
[3]
Even though the vaccine is developed in chicken cells, it is generally safe to give to those with
egg allergies
.
[3]
Most of the
developed world
and many countries in the
developing world
include it in their immunization programs often in combination with
measles
and
rubella vaccine
known as
MMR
.
[1]
A formulation with the previous three and the
varicella (chickenpox) vaccine
known as
MMRV
is also available.
[3]
As of 2005, 110 countries provided the vaccine as part of their immunization programs.
[1]
In areas where widespread vaccination is carried out it has resulted in a more than 90% decline in rates of disease.
[1]
Almost half a billion doses of one variety of the vaccine has been given.
[1]
History
[
edit
]
In the mid-twentieth century, mumps infections among children were not viewed as a serious public health issue, but adult men may develop debilitating
testicular
inflammation, which posed particular difficulty among close-quartered soldiers during wartime. As a result, during
World War II
(1939-1945), the
United States
government targeted mumps for scientific research.
[4]
The first experimental mumps vaccine was licensed in 1948; developed from
inactivated
virus, it only had short-term effectiveness.
[3]
Improved vaccines became commercially available in the 1960s.
[1]
In 1963,
Maurice Hilleman
of
Merck & Co.
took samples of the mumps virus from his daughter, who had contracted the disease; she became the namesake for the resulting
Jeryl Lynn
strain.
[4]
[5]
Building on then-recent advances that had led to vaccines for
polio
and
measles
, the mumps virus strains were developed in embryonic hens' eggs and chick embryo cell cultures.
[4]
The resulting strains of virus were less well-suited for human cells, and are thus said to be
attenuated
. They are sometimes referred to as
neuroattenuated
in the sense that these strains are less
virulent
to human
neurons
than the wild strains.
[6]
[7]
Hilleman's work led to the first effective mumps vaccine, called Mumpsvax. Licensed in 1967, its four-year development set a record for fastest development of a new vaccine,
[4]
a record later surpassed by the
COVID-19 vaccine
, which was developed in less than a year.
[8]
Vaccination against mumps did not become routine until Mumpsvax was included in Merck's combined
MMR vaccine
, which targeted
measles
and
rubella
along with mumps.
[4]
[2]
[9]
MMR was licensed in 1971, and 40 percent of American children had received the combined vaccine by 1974. In 1977, the U.S.
Centers for Disease Control and Prevention
(CDC) recommended mumps immunization (as part of MMR) for all children over 12 months of age, and in 1998, CDC began recommending a two-dose immunization of MMR.
[4]
Types
[
edit
]
While the initial vaccine in the 1940s was based on inactivated virus, subsequent preparations since the 1960s consist of live virus that has been weakened.
[1]
Mumps vaccine is on the
World Health Organization's List of Essential Medicines
.
[10]
[11]
There are a number of different types in use as of 2007.
[1]
Mumpsvax is
Merck
's brand of
Jeryl Lynn
strain vaccines.
[12]
[13]
It is a component of Merck's three-virus
MMR vaccine
, and is the mumps vaccine standard in the United States.
[14]
Mumpsvax is given by a
subcutaneous injection
of live virus reconstituted from freeze-dried (
lyophilized
) vaccine.
[13]
Production of Mumpsvax as a stand-alone product ceased in 2009.
[15]
[16]
The cells used in culture, virus stocks used, and animal fluids are all screened for extraneous material as part of the vaccine production. They are grown in
Medium 199
(a solution containing buffered salt, vitamins, amino acids, fetal bovine serum) with SPGA (sucrose, phosphate, glutamate,
human serum albumin
) and
neomycin
. The human albumin processing uses the
Cohn cold ethanol fractionation
method.
[13]
Other types
[
edit
]
- RIT 4385 is a newer strain derived from the Jeryl Lynn strain
[2]
by
Maurice Hilleman
, Jeryl Lynn's father.
- Leningrad-3 strain was developed by Smrodintsev and Klyachko in guinea pig kidney cell culture and has been used since 1950 in former Soviet countries.
[17]
This vaccine is routinely used in Russia.
- L-Zagreb strain used in
Croatia
and
India
was derived from the Leningrad-3 strain by further
passaging
.
[17]
- Urabe strain was introduced in Japan, and later licensed in Belgium, France and Italy. It has been associated with a higher incidence of meningitis (1/143 000 versus 1/227 000 for J-L),
[18]
and abandoned in several countries. It was formulated as MMR in the UK.
- Rubini strain used mainly in
Switzerland
was attenuated by a higher number of passes through chicken embryos, and later proved to have low potency.
[19]
It was introduced in 1985.
[17]
Illegal importation of ineffective version into the UK
[
edit
]
Monovalent mumps vaccine (Mumpsvax) remained available in the US when MMR was introduced in the UK, replacing the MR (measles and rubella) mixed vaccine. No UK-licensed monovalent preparation was ever available.
[20]
Monovalent mumps vaccines were available before MMR, but only used on a limited scale.
[21]
[22]
This became the subject of considerable argument at the end of the 20th century, since some parents preferred to obtain individually the components of the MMR mixture. One mumps vaccine preparation imported into the United Kingdom and unlicensed, proved to be essentially ineffective.
[23]
Immunisation against mumps in the UK became routine in 1988, commencing with MMR. The Aventis-Pasteur "MMR-2" brand is usual in the UK in 2006
[
citation needed
]
.
Storage and stability
[
edit
]
The
cold chain
is a major consideration in vaccination, particularly in less-developed countries. Mumps vaccines are normally refrigerated, but have a long half-life of 65 days at 23 degrees Celsius.
[17]
References
[
edit
]
- ^
a
b
c
d
e
f
g
h
i
j
k
l
m
n
o
p
q
World Health Organization
(February 2007). "Mumps virus vaccines".
Releve Epidemiologique Hebdomadaire
.
82
(7): 51?60.
hdl
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10665/240868
.
PMID
17304707
.
- ^
a
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Hviid A, Rubin S, Muhlemann K (March 2008). "Mumps".
Lancet
.
371
(9616): 932?944.
doi
:
10.1016/S0140-6736(08)60419-5
.
PMID
18342688
.
S2CID
208793825
.
- ^
a
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d
e
f
g
Atkinson W (May 2012).
Mumps Epidemiology and Prevention of Vaccine-Preventable Diseases
(12 ed.). Public Health Foundation. pp. Chapter 14.
ISBN
9780983263135
.
Archived
from the original on 6 July 2016.
- ^
a
b
c
d
e
f
Roos D.
"How a New Vaccine Was Developed in Record Time in the 1960s"
.
HISTORY
. Retrieved
17 November
2020
.
- ^
Young ML, Dickstein B, Weibel RE, Stokes J, Buynak EB, Hilleman MR (November 1967). "Experiences with Jeryl Lynn strain live attenuated mumps virus vaccine in a pediatric outpatient clinic".
Pediatrics
.
40
(5). American Academy of Pediatrics: 798?803.
doi
:
10.1542/peds.40.5.798
.
PMID
6075651
.
S2CID
35878536
.
- ^
"Immunization, Vaccines and Biologicals"
.
World Health Organization
. 2003. Archived from
the original
on 15 April 2006.
- ^
Rubin SA, Amexis G, Pletnikov M, Li Z, Vanderzanden J, Mauldin J, et al. (November 2003).
"Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype"
.
Journal of Virology
.
77
(21): 11616?11624.
doi
:
10.1128/JVI.77.21.11616-11624.2003
.
PMC
229304
.
PMID
14557647
.
- ^
Cohen S (10 December 2020).
"The fastest vaccine in history"
.
UCLA Health
. Retrieved
20 December
2021
.
- ^
Kowalzik F, Faber J, Knuf M (August 2018). "MMR and MMRV vaccines".
Vaccine
.
36
(36): 5402?5407.
doi
:
10.1016/j.vaccine.2017.07.051
.
PMID
28757060
.
S2CID
41538500
.
- ^
World Health Organization
(2019).
World Health Organization model list of essential medicines: 21st list 2019
. Geneva: World Health Organization.
hdl
:
10665/325771
. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^
World Health Organization
(2021).
World Health Organization model list of essential medicines: 22nd list (2021)
. Geneva: World Health Organization.
hdl
:
10665/345533
. WHO/MHP/HPS/EML/2021.02.
- ^
Hilleman MR, Buynak EB, Weibel RE, Stokes J (February 1968). "Live, attenuated mumps-virus vaccine".
The New England Journal of Medicine
.
278
(5): 227?232.
doi
:
10.1056/NEJM196802012780501
.
PMID
4169706
.
- ^
a
b
c
Merck Co.
(1999).
"MUMPSVAX (Mumps Virus Vaccine Live) Jeryl Lynn Strain"
(PDF)
. Merck Co. Archived from
the original
(PDF)
on 13 August 2006.
- ^
Merck Co.
(1999).
"M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live)"
(PDF)
. Merck Co.
- ^
"Vaccines: Vac-Gen/Shortages/MMR single dose vaccine shortage questions"
.
www.cdc.gov
. Archived from
the original
on 17 March 2009.
- ^
Smith R (24 November 2009).
"Single mumps vaccine production stops"
.
The Telegraph
. London: Telegraph Media Group Limited
. Retrieved
14 February
2016
.
- ^
a
b
c
d
"Immunizations, Vaccines and Biologicals - The Mumps Vaccine"
.
World Health Organization
. Archived from
the original
on 23 April 2006.
- ^
"MMR Vaccine"
. Pediatric Oncall. 7 January 2006. Archived from
the original
on 30 April 2007.
- ^
"Eurosurveillance report on Portugal outbreak"
. Archived from
the original
on 7 September 2005.
- ^
Smith R (24 November 2009).
"Single mumps vaccine production stops"
.
Telegraph
. Retrieved
18 March
2020
.
- ^
Donaldson RJ, Donaldson LJ (6 December 2012).
"Origin of diseases and their prevention"
.
Essential Community Medicine: (including relevant social services)
. Springer Science & Business Media.
ISBN
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.
- ^
Forsey T (July 1994).
"Mumps vaccines--current status"
.
Journal of Medical Microbiology
.
41
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.
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.
- ^
Pavivac ineffective.
CMO's letter HSSMD33-02
::
Archived
27 September 2007 at the
Wayback Machine
Nov. 2002
Further reading
[
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]
External links
[
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]
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