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German-born American biophysicist and Nobel laureate (born 1940)
Joachim Frank
(
German pronunciation:
[?joːax?m
?f?aŋk]
ⓘ
)
HonFRMS
; born September 12, 1940) is a German-American
biophysicist
at
Columbia University
and a Nobel laureate. He is regarded as the founder of single-particle
cryo-electron microscopy
(cryo-EM), for which he shared the
Nobel Prize in Chemistry
in 2017 with
Jacques Dubochet
and
Richard Henderson
.
[2]
He also made significant contributions to structure and function of the
ribosome
from bacteria and eukaryotes.
Life and career
[
edit
]
Frank was born in
Siegen
in the borough of
Weidenau
. After completing his Vordiplom (B.S.) degree in physics at the
University of Freiburg
(1963)
[3]
and his
Diplom
under
Walter Rollwagen
's mentorship at the
Ludwig Maximilian University of Munich
with the thesis "Untersuchung der Sekundarelektronen-Emission von Gold am Schmelzpunkt" (Investigation of secondary electron emission of gold at its melting point) (1967), Frank obtained his Ph.D. from the
Technical University of Munich
for graduate studies in
Walter Hoppe
's lab at the Max Planck Institut fur Eiweiss- und Lederforschung (now
Max Planck Institute of Biochemistry
) with the dissertation
Untersuchungen von elektronenmikroskopischen Aufnahmen hoher Auflosung mit Bilddifferenz- und Rekonstruktionsverfahren
[4]
(Investigations of high-resolution electron micrographs using image difference and reconstruction methods) (1970). The thesis explores the use of digital image processing and optical diffraction in the analysis of electron micrographs, and alignment of images using the cross-correlation function.
As a
Harkness postdoctoral fellow
, he had the opportunity to study for two years in the United States: with Robert Nathan at the
Jet Propulsion Laboratory
,
California Institute of Technology
; with
Robert M. Glaeser
at Donner Lab,
University of California, Berkeley
and with
Benjamin M. Siegel
at
Cornell University
, Ithaca, New York.
[5]
[6]
[7]
In the fall of 1972 he returned briefly to the
Max Planck Institute of Biochemistry
in Martinsried as research assistant, working on the theory of partial coherence in electron microscopy,
[8]
then, in 1973, he joined the
Cavendish Laboratory
,
University of Cambridge
as Senior Research Assistant under
Vernon Ellis Cosslett
.
In 1975 Frank was offered a position of senior research scientist in the Division of Laboratories and Research (now
Wadsworth Center
), New York State Department of Health,
[6]
[9]
where he started working on single-particle approaches in electron microscopy.
[10]
In 1985 he was appointed associate and then (1986) full professor at the newly formed Department of Biomedical Sciences of the
University at Albany, State University of New York
. In 1987 and 1994, he went on sabbaticals in Europe, one to work with
Richard Henderson
,
Laboratory of Molecular Biology
Medical Research Council in
Cambridge
and the other as a
Humboldt Research Award
winner with
Kenneth C. Holmes
,
Max Planck Institute for Medical Research
in
Heidelberg
.
[6]
In 1998 Frank was appointed investigator of the
Howard Hughes Medical Institute
(HHMI). Since 2003 he was also lecturer at
Columbia University
, and he joined
Columbia University
in 2008 as professor of
Biochemistry and Molecular Biophysics
and of biological sciences.
Awards (selection)
[
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]
Selected publications
[
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]
Books
[
edit
]
- Frank, Joachim (2014),
Found in Translation ? Collection of Original Articles on Single-Particle Reconstruction and the Structural Basis of Protein Synthesis
, Singapore: World Scientific Press,
ISBN
978-981-4522-80-9
.
- Herman, Gabor T.; Frank, Joachim (2014),
Computational Methods for Three-Dimensional Microscopy Reconstruction
, springer,
ISBN
978-1-4614-9520-8
.
- Frank, Joachim (2011),
Molecular Machines in Biology: Workshop of the Cell
, Cambridge:
Cambridge University Press
,
ISBN
978-0-521-19428-0
.
- Glaeser, Robert M.; Downing, Ken; Chiu, Wah; Frank, Joachim; DeRosier, David (2007),
Electron Crystallography of Biological Macromolecules
, Oxford:
Oxford University Press
,
ISBN
978-0-19-508871-7
.
- Frank, Joachim (2006),
Electron Tomography
(2nd ed.), New York: Springer,
ISBN
978-0-387-31234-7
.
- Frank, Joachim (2006),
Three-Dimensional Electron Microscopy of Macromolecular Assemblies
(2nd ed.), Oxford:
Oxford University Press
,
ISBN
978-0-19-518218-7
.
Articles
[
edit
]
References
[
edit
]
- ^
Frank, Joachim (2017),
Curriculum Vitae
Archived
October 9, 2017, at the
Wayback Machine
. Retrieved October 4, 2017.
- ^
"The Nobel Prize in Chemistry 2017"
. The Nobel Foundation. October 4, 2017
. Retrieved
October 6,
2017
.
- ^
Entry in the University Archive Freiburg, Prufungsausschuss fur Diplom-Physiker B 11/593
- ^
Entry in the catalogue of the Deutsche Nationalbibliothek:
DNB 482124628
- ^
"Joachim Frank, PhD | P&S; Research"
. Archived from
the original
on October 9, 2017
. Retrieved
October 5,
2017
.
- ^
a
b
c
Mossman, Kaspar (December 11, 2007).
"Profile of Joachim Frank"
.
Proc. Natl. Acad. Sci. U.S.A
.
104
(50): 19668?70.
Bibcode
:
2007PNAS..10419668M
.
doi
:
10.1073/pnas.0710323105
.
PMC
2148354
.
PMID
18056798
.
- ^
a
b
"Archived copy"
(PDF)
. Archived from
the original
(PDF)
on October 9, 2017
. Retrieved
October 4,
2017
.
{{
cite web
}}
: CS1 maint: archived copy as title (
link
)
- ^
Frank, Joachim (1973), "The envelope of electron microscopic transfer functions for partially coherent illumination",
Optik
,
38
: 519?539
.
- ^
Wicher, Konrad (2006).
History of the electron microscope: the high voltage electron microscope and beyond at the Division of Laboratories and Research/Wadsworth Center
. Albany, New York: Wadsworth Center, New York State Department of Health. p. 149.
- ^
Frank, Joachim (1975). "Averaging of low-exposure electron micrographs of non-periodic objects".
Ultramicroscopy
.
1
(2): 159?162.
doi
:
10.1016/s0304-3991(75)80020-9
.
PMID
1236029
.
- ^
Book of Members 1780?present
(PDF, 878 kB) at
American Academy of Arts and Sciences
(amacad.org); Retrieved February 23, 2017.
- ^
"Joachim Frank"
.
nasonline.org
. January 12, 2006
. Retrieved
February 23,
2017
.
- ^
"Joachim Frank"
.
fi.edu
. December 12, 2014
. Retrieved
February 23,
2017
.
- ^
"The 16th Annual Wiley Prize in Biomedical Sciences Awarded for Pioneering Developments in Electron Microscopy"
.
newsroom.wiley.com
. February 22, 2017. Archived from
the original
on October 4, 2017
. Retrieved
February 23,
2017
.
- ^
"Nobel Prize in Chemistry Awarded for Cryo-Electron Microscopy"
.
The New York Times
. October 4, 2017
. Retrieved
October 4,
2017
.
- ^
"Respect and Recognition"
.
uni-siegen.de
. April 17, 2018
. Retrieved
October 2,
2018
.
Further reading
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