Casimir Funk

Kazimierz Funk
Kazimierz Funk
Sinh	Kazimierz Funk ; 23 thang 2, 1884 ; Warsaw , Congress Poland
M?t	19 thang 11, 1967 (83 tu?i) ; Albany, New York , Hoa K?
Qu?c t?ch	Ba Lan
T? cach cong dan	Ba Lan ; Hoa K?
Tr??ng l?p	đ?i hoc Bern , Th?y S?
N?i ti?ng vi	Nghien c?u v? dinh d??ng, hinh thanh khai ni?m v? vitamin
	S? nghi?p khoa h?c
Nganh	Biochemist
N?i cong tac	Pasteur Institute ; Lister Institute ; Funk Foundation for Medical Research

Kazimierz Funk ^[1] ( ti?ng Ba Lan: [ka??imj?? ?fuŋk] ; Ngay 23 thang 2 n?m 1884 - 19 thang 11 n?m 1967 ^[2]), th??ng đ??c Anh hoa ten la Casimir Funk , la m?t nha hoa sinh ng??i Ba Lan , ^[3] th??ng đ??c ghi nh?n la m?t trong nh?ng ng??i đ?u tien hinh thanh (n?m 1912) khai ni?m v? vitamin , ^[4] ong g?i chung la "amin quan tr?ng" (vital amins) hay "vitamines".

Thanh t?u [ s?a | s?a ma ngu?n ]

Sau khi đ?c m?t bai bao c?a ng??i Ha Lan Christiaan Eijkman ch? ra r?ng nh?ng ng??i ?n g?o l?c it b? t?n th??ng do ch?ng beri-beri so v?i nh?ng ng??i ch? ?n g?o đ??c xay nhuy?n hoan toan, Funk đa c? g?ng co l?p ch?t ch?u trach nhi?m cho s? khac bi?t nay va ong đa thanh cong. Vi ch?t đo ch?a m?t nhom amin , ong g?i no la "vitamine". Sau nay no đ??c g?i la vitamin B ₃ ( niacin ), m?c du ong ngh? r?ng đo s? la thiamine (vitamin B ₁) va mo t? no la "y?u t? ch?ng l?i b?nh beri-beri". N?m 1911, ong đa xu?t b?n bai bao đ?u tien b?ng ti?ng Anh, v? dihydroxyphenylalanine. Funk ch?c ch?n r?ng co nhi?u h?n m?t ch?t nh? Vitamin B1, va trong bai bao n?m 1912 c?a minh cho T?p chi Y h?c Nha n??c, ong đa đ? xu?t s? t?n t?i c?a it nh?t b?n lo?i vitamin: m?t lo?i ng?n ng?a beriberi (lo?i antiberiberi); m?t lo?i ng?n ng?a b?nh scorbut (antiscorbutic); m?t lo?i ng?n ng?a b?nh n?m da (antipellagric); va m?t trong nh?ng phong ch?ng coi x??ng (antirachitic). T? đo, Funk xu?t b?n m?t cu?n sach, The Vitamines , vao n?m 1912, va cu?i n?m đo đa nh?n đ??c h?c b?ng Beit đ? ti?p t?c nghien c?u v? l?nh v?c nay. ^[5]

Funk đ? xu?t gi? thuy?t r?ng cac b?nh khac, ch?ng h?n nh? coi x??ng , Pellagra , b?nh celiac va b?nh coi c?ng co th? đ??c ch?a kh?i b?ng vitamin. ^[6]

Funk la ng??i nghien c?u ban đ?u v? v?n đ? c?a b?nh n?m. Ong cho r?ng m?t s? thay đ?i trong ph??ng phap nghi?n ngo la nguyen nhan gay ra s? bung phat c?a vi khu?n, ^[7] nh?ng khong ai chu y đ?n bai vi?t c?a ong v? ch? đ? nay. ^[8]

Ch? "e" ? cu?i "vitamine" sau đo đa b? lo?i b?, khi cac nghien c?u nh?n ra r?ng vitamin khong c?n thi?t ph?i la amin ch?a nit?.

Ong c?ng neu ra s? t?n t?i c?a cac ch?t dinh d??ng thi?t y?u khac, đ??c bi?t đ?n nh? vitamin B ₁, B ₂, C va D.

N?m 1936, ong đa xac đ?nh c?u truc phan t? c?a thiamine , m?c du ong khong ph?i la ng??i đ?u tien phan tach co l?p ch?t nay.

Funk c?ng đa ti?n hanh nghien c?u v? hormone , b?nh ti?u đ??ng , loet d? day va sinh hoa ung th? .

Sau khi tr? v? Hoa K?, n?m 1940, ong tr? thanh ch? t?ch c?a Qu? nghien c?u y t? Funk. Ong đa danh nh?ng n?m cu?i đ?i đ? nghien c?u cac nguyen nhan gay ra b?nh ung th? .

Tham kh?o [ s?a | s?a ma ngu?n ]

^ Iłowiecki, Maciej (1981). Dzieje nauki polskiej (History of Polish Science) . Warszawa: Wydawnictwo Interpress. tr. 177. ISBN 978-83-223-1876-8 .
^ (ti?ng Anh) Griminger P Casimir Funk A Biographical Sketch (1884?1967). Journal of Nutrition 1972 Sep;102(9):1105?13. PMID 4560436 . Available from: http://jn.nutrition.org/content/102/9/1105.full.pdf
^ George Rosen , A History of Public Health , JHU Press (2015), p. 240
^ Just The Facts-Inventions & Discoveries, School Specialty Publishing, 2005
^ Funk, Casimir (1914). Die Vitamine, ihre Bedeutung fur die Physiologie und Pathologie: mit besonderer Berucksichtigung der Avitaminosen: (Beriberi, Skorbut, Pellagra, Rachitis); Anhang: Die Wachstumsubstanz und das Krebsproblem . Wiesbaden: J. F. Bergmann . Truy c?p ngay 23 thang 10 n?m 2018 – qua Internet Archive. . See also Funk, Casimir (1922). The Vitamines . Dubin, Harry E. from the Second German Edition bien d?ch. Baltimore: Williams & Wilkins . Truy c?p ngay 26 thang 10 n?m 2018 – qua Internet Archive.
^ Funk, Casimir (1912). “The etiology of the deficiency diseases. Beri-beri, polyneuritis in birds, epidemic dropsy, scurvy, experimental scurvy in animals, infantile scurvy, ship beri-beri, pellagra”. Journal of State Medicine . 20 : 341?68.
^ Funk, C (1913). “Studies on pellagra. The influence of the milling of maize on the chemical composition and nutritive value of the meal” . J Physiol . 47 (4?5): 389?392. doi : 10.1113/jphysiol.1913.sp001631 . PMC 1420484 . PMID 16993244 .
^ Alfred, JAY Bollet (1992). “Politics and Pellagra: The Epidemic of Pellagra in the U.S. in the Early Twentieth Century” (PDF) . The Yale Journal of Biology and Medicine . 65 (3): 211?221. PMC 2589605 . PMID 1285449 .

[1] Iłowiecki, Maciej (1981). Dzieje nauki polskiej (History of Polish Science) . Warszawa: Wydawnictwo Interpress. tr. 177. ISBN 978-83-223-1876-8 .

[PMID_4560436-2] (ti?ng Anh) Griminger P Casimir Funk A Biographical Sketch (1884?1967). Journal of Nutrition 1972 Sep;102(9):1105?13. PMID 4560436 . Available from: http://jn.nutrition.org/content/102/9/1105.full.pdf

[3] George Rosen , A History of Public Health , JHU Press (2015), p. 240

[4] Just The Facts-Inventions & Discoveries, School Specialty Publishing, 2005

[5] Funk, Casimir (1914). Die Vitamine, ihre Bedeutung fur die Physiologie und Pathologie: mit besonderer Berucksichtigung der Avitaminosen: (Beriberi, Skorbut, Pellagra, Rachitis); Anhang: Die Wachstumsubstanz und das Krebsproblem . Wiesbaden: J. F. Bergmann . Truy c?p ngay 23 thang 10 n?m 2018 – qua Internet Archive. . See also Funk, Casimir (1922). The Vitamines . Dubin, Harry E. from the Second German Edition bien d?ch. Baltimore: Williams & Wilkins . Truy c?p ngay 26 thang 10 n?m 2018 – qua Internet Archive.

[6] Funk, Casimir (1912). “The etiology of the deficiency diseases. Beri-beri, polyneuritis in birds, epidemic dropsy, scurvy, experimental scurvy in animals, infantile scurvy, ship beri-beri, pellagra”. Journal of State Medicine . 20 : 341?68.

[7] Funk, C (1913). “Studies on pellagra. The influence of the milling of maize on the chemical composition and nutritive value of the meal” . J Physiol . 47 (4?5): 389?392. doi : 10.1113/jphysiol.1913.sp001631 . PMC 1420484 . PMID 16993244 .

[8] Alfred, JAY Bollet (1992). “Politics and Pellagra: The Epidemic of Pellagra in the U.S. in the Early Twentieth Century” (PDF) . The Yale Journal of Biology and Medicine . 65 (3): 211?221. PMC 2589605 . PMID 1285449 .

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