??????????

??????????
???????????????
???????????????	/ s ? l ? d ? n ? f ? l / sil- den -?-fil
?????????????	Viagra, Revatio, others
AHFS / Drugs.com	????????
MedlinePlus	a699015
???????????????	TH Ya&You : Sildenafil ; EU EMA : by INN ; US FDA : Sildenafil ;
?????????????????????????????	AU : B1 ; US : B (??????????????????????) ; ;
???????????????	By mouth ( tablets ), IV
???? ATC	G04BE03 ( WHO ) ;
??????
??????????????	AU : S4 (???????????????) ; CA : ?-only ; UK : POM (Prescription only) ; US : ?-only ; In general: ? (Prescription only) ;
?????? ??????????????
?????????????	41% (mean)
???????????????	~96%
????????????????	Liver : CYP3A4 (major route), CYP2C9 (minor route)
??????????????????????????????	N -desmethylsildenafil (~50% potency for PDE 5 )
???????????????????	3?4 hours
?????????	Feces (~80%), urine (~13%)
?????????
	??????????? IUPAC 5-{2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1 H ,6 H ,7 H -pyrazolo[4,3-d]pyrimidin-7-one ;
?????????? CAS	139755-83-2 ; Citrate: 171599-83-0 ;
PubChem CID	5212 ;
DrugBank	DB00203 ;
ChemSpider	5023 ;
UNII	3M7OB98Y7H ;
KEGG	D08514 ;
ChEBI	CHEBI:9139 ;
ChEMBL	CHEMBL192 ;
PDB ligand	VIA ( PDBe , RCSB PDB ) ;
ECHA InfoCard	100.122.676
??????????????????????
????	C 22 H 30 N 6 O 4 S
?????????	474.5764 g/mol g·mol ?1
???????? 3D ( JSmol )	Interactive image ;
	SMILES CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C ;
	InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) ; Key:BNRNXUUZRGQAQC-UHFFFAOYSA-N ;
7 (what is this?) (verify)
??????????????????

???????????????? ( ?????? : Sildenafil citrate ) ?????????????????????????????? ???????? ( ?????? : Viagra ) ???????????????????????????? ???????????????????????????? ???????????????????????? ??? ????????????????????????????? (PAH) ^[3] ??????????????????????????????????????????????????????????????????????????????????????? ^[3]

??????????????????????? ?????? ?????? ??? ?????????????? ?????????????????????????????????? ??????????????? ???????? ???????????????????????????????????????????????????? ?????????????????????????????????????????? ?????? ?????????????????? ????????????????????????? ?????? ?????? ???????????????? ?????????????? ????????????????????????????????????? ?????? ????????? ?????????????? (glycerin trinitrate) ?????????????????????? ???????????? ??????????????????????????????? ^[3]

?????????????????????????? cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE ₅) ???????? ??????? ??????????????????????? cGMP ??????????????????????????????????????????? ??????

?????????????????????????????? Pfizer ?????? Andrew Bell, David Brown ??? Nicholas Terrett ???????????????????????????????? ?????????????????????????????????? ??????????? ^[4]^[5] ??????????????? ?.?. 1988 ??????????????????????????????????????????????????????????????????????? ????????????????????????????????????????? ???? Tadalafil (?????????? Cialis) ??? Vardenafil (?????????? Levitra)

??????????? [ ??? ]

???????????????????????????????? ???????????????????????????????? ???????????? ????????????????????????????????? ??????????????????????????????? ^[6]

??????? [ ??? ]

↑ Nichols, DJ; Muirhead, GJ; Harness, JA (6 March 2002). "Pharmacokinetics of Sildenafil after Single Oral Doses in Healthy Male Subjects: Absolute Bioavailability, Food Effects and Dose Proportionality" . British Journal of Clinical Pharmacology . 53 : 5S?12S. doi : 10.1046/j.0306-5251.2001.00027.x . PMC 1874258 . PMID 11879254 .
↑ "Viagra (sildenafil citrate) Tablets, for Oral Use. Full Prescribing Information" . Pfizer Labs. Division of Pfizer, Inc., NY, NY 10017 . ??????????? 5 November 2016 .
↑ ^3.0 ^3.1 ^3.2 "Sildenafil Citrate" . The American Society of Health-System Pharmacists . ??????????? Dec 1, 2014 .
↑ "Patent US5250534 - Pyrazolopyrimidinone antianginal agents - Google Patents" .
↑ Boolell, M; Allen, MJ; Ballard, SA; Gepi-Attee, S; Muirhead, GJ; Naylor, AM; Osterloh, IH; Gingell, C (June 1996). "Sildenafil: an Orally Active Type 5 Cyclic GMP-Specific Phosphodiesterase Inhibitor for the Treatment of Penile Erectile Dysfunction". International Journal of Impotence Research . 8 (2): 47?52. PMID 8858389 .
↑ http://elib-online.com/doctors/warn_viagra1.html

?????? ????????? ??? ?? ?????????? ???? ???????????????????????????????? ???????????????

[1] Nichols, DJ; Muirhead, GJ; Harness, JA (6 March 2002). "Pharmacokinetics of Sildenafil after Single Oral Doses in Healthy Male Subjects: Absolute Bioavailability, Food Effects and Dose Proportionality" . British Journal of Clinical Pharmacology . 53 : 5S?12S. doi : 10.1046/j.0306-5251.2001.00027.x . PMC 1874258 . PMID 11879254 .

[PI-2] "Viagra (sildenafil citrate) Tablets, for Oral Use. Full Prescribing Information" . Pfizer Labs. Division of Pfizer, Inc., NY, NY 10017 . ??????????? 5 November 2016 .

[AHFS2014-3] 3.0 ^3.1 ^3.2 "Sildenafil Citrate" . The American Society of Health-System Pharmacists . ??????????? Dec 1, 2014 .

[google.com-4] "Patent US5250534 - Pyrazolopyrimidinone antianginal agents - Google Patents" .

[Boolell-5] Boolell, M; Allen, MJ; Ballard, SA; Gepi-Attee, S; Muirhead, GJ; Naylor, AM; Osterloh, IH; Gingell, C (June 1996). "Sildenafil: an Orally Active Type 5 Cyclic GMP-Specific Phosphodiesterase Inhibitor for the Treatment of Penile Erectile Dysfunction". International Journal of Impotence Research . 8 (2): 47?52. PMID 8858389 .

[6] ttp://elib-online.com/doctors/warn_viagra1.html

[1]

[2]

[3]

[4]

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