US government medical research agency
The
National Institutes of Health
, commonly referred to as
NIH
, is the primary agency of the
United States government
responsible for
biomedical
and
public health
research. It was founded in the late 1880s and is now part of the
United States Department of Health and Human Services
. Many NIH facilities are located in
Bethesda, Maryland
, and other nearby suburbs of the
Washington metropolitan area
, with other primary facilities in the
Research Triangle Park
in
North Carolina
and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the
NIH Intramural Research Program
(IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.
As of 2013
[update]
, the IRP had 1,200
principal investigators
and more than 4,000
postdoctoral
fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world,
[1]
while, as of 2003, the extramural arm provided 28% of biomedical research funding spent annually in the U.S., or about US$26.4 billion.
[2]
The NIH comprises
27 separate institutes and centers
of different biomedical disciplines and is responsible for many scientific accomplishments, including the discovery of fluoride to prevent
tooth decay
, the use of
lithium
to manage
bipolar disorder
, and the creation of
vaccines
against
hepatitis
,
Haemophilus influenzae
(HIB), and
human papillomavirus
(HPV).
[3]
In 2019, the NIH was ranked number two in the world, behind
Harvard University
, for biomedical sciences in the
Nature Index
, which measured the largest contributors to papers published in a subset of leading
journals
from 2015 to 2018.
[4]
[5]
History
[
edit
]
Origins
[
edit
]
In 1887, a laboratory for the study of bacteria, the
Hygienic Laboratory
, was established within the
Marine Hospital Service
, which at the time was expanding its functions beyond the
system of Marine Hospitals
into quarantine and research programs. It was initially located at the
New York Marine Hospital
on
Staten Island
.
[7]
[8]
[9]
In 1891, it moved to the top floor of the
Butler Building
in
Washington, D.C.
In 1904, it moved again to a new campus at the
Old Naval Observatory
, which grew to include five major buildings.
[10]
In 1901, the
Division of Scientific Research
was formed, which included the Hygienic Laboratory as well as other research offices of the Marine Hospital Service.
[11]
In 1912, the Marine Hospital Service became the
Public Health Service
(PHS).
[9]
In 1922, PHS established a Special Cancer Investigations laboratory at
Harvard Medical School
. This marked the beginning of a partnership with universities.
[9]
In 1930, the Hygienic Laboratory was re-designated as the National Institute of Health by the
Ransdell Act
, and was given $750,000 to construct two NIH buildings at the Old Naval Observatory campus.
[9]
In 1937, NIH absorbed the rest of the Division of Scientific Research, of which it was formerly part.
[11]
[12]
In 1938, NIH moved to
its current campus
in
Bethesda, Maryland
.
[9]
Over the next few decades, Congress would markedly increase funding of the NIH, and various institutes and centers within the NIH were created for specific research programs.
[9]
In 1944, the
Public Health Service Act
was approved, and the
National Cancer Institute
became a division of NIH. In 1948, the name changed from National Institute of Health to National Institutes of Health.
Later history
[
edit
]
In the 1960s, virologist and cancer researcher
Chester M. Southam
injected
HeLa
cancer cells into patients at the Jewish Chronic Disease Hospital.
[13]
: 130
When three doctors resigned after refusing to inject patients without their consent, the experiment gained considerable media attention.
[13]
: 133
The NIH was a major source of funding for Southam's research and had required all research involving human subjects to obtain their consent prior to any experimentation.
[13]
: 135
Upon investigating all of their grantee institutions, the NIH discovered that the majority of them did not protect the rights of human subjects. From then on, the NIH has required all grantee institutions to approve any research proposals involving human experimentation with review boards.
[13]
: 135
In 1967, the Division of Regional Medical Programs was created to administer grants for research for heart disease, cancer, and
strokes
. That same year, the NIH director lobbied the White House for increased federal funding in order to increase research and the speed with which health benefits could be brought to the people. An advisory committee was formed to oversee the further development of the NIH and its research programs. By 1971 cancer research was in full force and President Nixon signed the
National Cancer Act
, initiating a National Cancer Program, President's Cancer Panel, National Cancer Advisory Board, and 15 new research, training, and demonstration centers.
[14]
Funding for the NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research, and 85 percent of all funding for health studies in universities.
[15]
While government funding for research in other disciplines has been increasing at a rate similar to inflation since the 1970s, research funding for the NIH nearly tripled through the 1990s and early 2000s, but has remained relatively stagnant since then.
[16]
By the 1990s, the NIH committee focus had shifted to DNA research and launched the
Human Genome Project
.
[17]
Leadership
[
edit
]
The NIH
Office of the Director
is the central office responsible for setting policy for NIH, and for planning, managing, and coordinating the programs and activities of all NIH components. The NIH Director plays an active role in shaping the agency's activities and outlook. The Director is responsible for providing leadership to the Institutes and Centers by identifying needs and opportunities, especially in efforts involving multiple Institutes.
[18]
Within the Director's Office is the
Division of Program Coordination, Planning and Strategic Initiatives
with 12 divisions including:
The Agency Intramural Research Integrity Officer "is directly responsible for overseeing the resolution of all research misconduct allegations involving
intramural research
, and for promoting research integrity within the NIH Office of Intramural Research (OIR)."
[19]
There is a Division of Extramural Activities, which has its own Director.
[20]
The Office of Ethics has its own Director,
[21]
as does the Office of Global Research.
[22]
Locations and campuses
[
edit
]
Intramural research is primarily conducted at the
main campus
in
Bethesda, Maryland
, and
Rockville, Maryland
, and the surrounding communities.
The Bayview Campus in
Baltimore
, Maryland houses the research programs of the
National Institute on Aging
,
National Institute on Drug Abuse
, and
National Human Genome Research Institute
with nearly 1,000 scientists and support staff.
[23]
The
Frederick National Laboratory
in
Frederick, MD
and the nearby Riverside Research Park, houses many components of the
National Cancer Institute
, including the Center for Cancer Research, Office of Scientific Operations, Management Operations Support Branch, the division of Cancer Epidemiology and Genetics and the division of Cancer Treatment and Diagnosis.
[24]
The
National Institute of Environmental Health Sciences
is located in the
Research Triangle
region of
North Carolina
.
Other ICs have satellite locations in addition to operations at the main campus. The
National Institute of Allergy and Infectious Diseases
maintains its Rocky Mountain Labs in
Hamilton, Montana
,
[25]
with an emphasis on
BSL3
and BSL4 laboratory work. NIDDK operates the Phoenix Epidemiology and Clinical Research Branch in
Phoenix, Arizona
.
Research
[
edit
]
As of 2017, 153 scientists receiving financial support from the NIH have been awarded a
Nobel Prize
and 195 have been awarded a
Lasker Award
.
[26]
Intramural and extramural research
[
edit
]
NIH devotes 10% of its funding to research within its own facilities (intramural research), and gives >80% of its funding in
research grants
to extramural (outside) researchers.
[27]
Of this extramural funding, a certain percentage (2.8% in 2014) must be granted to small businesses under the
SBIR/STTR
program.
[28]
As of 2011
[update]
, the extramural funding consisted of about 50,000 grants to more than 325,000 researchers at more than 3000 institutions.
[29]
By 2018
[update]
, this rate of granting remained reasonably steady, at 47,000 grants to 2,700 organizations.
[27]
In
FY
2010
[update]
, NIH spent
US$10.7bn
(not including temporary funding from the
American Recovery and Reinvestment Act of 2009
) on
clinical research
,
US$7.4bn
on
genetics
-related research,
US$6.0bn
on prevention research,
US$5.8bn
on cancer, and
US$5.7bn
on
biotechnology
.
[30]
Public Access Policy
[
edit
]
In 2008 a Congressional mandate called for investigators funded by the NIH to submit an electronic version of their final manuscripts to the
National Library of Medicine
's research repository,
PubMed Central
(PMC), no later than 12 months after the official date of publication.
[31]
The
NIH Public Access Policy
was the first public access mandate for a U.S. public funding agency.
[32]
Economic return
[
edit
]
In 2000, the Joint Economic Committee of Congress reported NIH research, which was funded at $16 billion a year in 2000, that some econometric studies had given a rate of return of 25 to 40 percent per year by reducing the economic cost of illness in the US. It found that of the 21 drugs with the highest therapeutic impact on society introduced between 1965 and 1992, public funding was "instrumental" for 15.
[33]
As of 2011 NIH-supported research helped to discover 153 new FDA-approved drugs, vaccines, and new indications for drugs in the 40 years prior.
[34]
One study found NIH funding aided either directly or indirectly in developing the drugs or drug targets for all of the 210 FDA-approved drugs from 2010 to 2016.
[35]
In 2015, Pierre Azoulay et al. estimated $10 million invested in research generated two to three new patents.
[36]
Notable discoveries and developments
[
edit
]
Since its inception, the NIH intramural research program has been a source of many pivotal scientific and medical discoveries. Some of these include:
- 1908:
George W. McCoy
's discovery that rodents were a reservoir of
bubonic plague
.
- 1911: George W. McCoy, Charles W. Chapin, William B. Wherry, and B. H. Lamb described the previously unknown
tularemia
.
- 1924: Roscoe R. Spencer and Ralph R. Parker developed a vaccine against
Rocky Mountain spotted fever
.
- 1930:
Sanford M. Rosenthal
developed a treatment for
mercury poisoning
used widely before the development of dimercaptoethanol.
- 1943: Wilton R. Earle pioneered the
cell culture
process and published a paper describing the production of malignancy in vitro, Katherine K. Sanford developed the first clone from an isolated cancer cell, and Virginia J. Evans devised a medium that supported growth of cells in vitro.
- 1940s?1950s:
Bernard Horecker
and colleagues described the
pentose phosphate pathway
.
- 1950s:
Julius Axelrod
discovered a new class of
enzymes
,
cytochrome P450
monooxygenases, a fundamental of drug metabolism.
- 1950:
Earl Stadtman
discovered phosphotransacetylose, elucidating the role of
acetyl CoA
in
fatty acid metabolism
.
- 1960s: Discovered the first human slow virus disease, kuru, which is a degenerative, fatal infection of the central nervous system. This discovery of a new mechanism for infectious diseases revolutionized thinking in
microbiology
and
neurology
.
- 1960s: Defined the mechanisms that regulate noradrenaline, one of the most important neurotransmitters in the brain.
- 1960s: Developed the first licensed rubella vaccine and the first test for rubella antibodies for large scale testing.
- 1960s: Developed an effective combination drug regimen for
Hodgkin's lymphoma
.
- 1960s: Discovery that tooth decay is caused by bacteria.
- 1970s: Developed the assay for
human chorionic gonadotropin
that evolved into the home pregnancy tests.
- 1970s: Described the hormonal cycle involved in menstruation.
- 1980s: Determined the complete structure of the
IgE receptor
that is involved in allergic reactions.
- 1990s: First trial of
gene therapy
in humans.
NIH Toolbox
[
edit
]
In September 2006, the NIH Blueprint for Neuroscience Research started a contract for the
NIH Toolbox
for the Assessment of Neurological and Behavioral Function to develop a set of state-of-the-art measurement tools to enhance collection of data in large cohort studies. Scientists from more than 100 institutions nationwide contributed. In September 2012, the NIH Toolbox was rolled out to the research community. NIH Toolbox assessments are based, where possible, on
Item Response Theory
and adapted for testing by computer.
[
citation needed
]
Database of Genotypes and Phenotypes
[
edit
]
NIH sponsors the Database of Genotypes and Phenotypes (dbGaP), a repository of information produced by studies investigating the interaction of genotype and phenotype. The information includes phenotypes, molecular assay data, analyses and documents. Summary-level data is available to the general public whereas the individual-level data is accessible to researchers.
[37]
According to the
City Journal
NIH denies access to such attributes as intelligence, education and health on the grounds that studying their genetic basis would be stigmatizing.
[38]
Coronavirus vaccine
[
edit
]
The NIH partnered with
Moderna
in 2020 during the
COVID-19 pandemic
to develop a vaccine. The final phase of testing began on July 27 with up to 30,000 volunteers assigned to one of two groups?one receiving the
mRNA-1273
vaccine and the other receiving salt water injections?and continued until there had been approximately 100 cases of COVID-19 among the participants.
[39]
[40]
In 2021, the NIH contributed $4,395,399 towards the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program.
[41]
Collaboration with Wuhan Institute of Virology
[
edit
]
Following the outbreak of the
COVID-19 pandemic
, NIH-funded
EcoHealth Alliance
has been the subject of controversy and increased scrutiny due to its ties to the
Wuhan Institute of Virology
(WIV)?which has been at the center of speculation since early 2020 that SARS-CoV-2 may have escaped in a lab incident.
[42]
[43]
[44]
[45]
[46]
Under political pressure, the NIH withdrew funding to EcoHealth Alliance in July 2020.
[47]
NIH Interagency Pain Research Coordinating Committee
[
edit
]
On February 13, 2012, the National Institutes of Health (NIH) announced a new group of individuals assigned to research pain. This committee is composed of researchers from different organizations and will focus to "coordinate pain research activities across the federal government with the goals of stimulating pain research collaboration… and providing an important avenue for public involvement" ("Members of new", 2012). With a committee such as this research will not be conducted by each individual organization or person but instead a collaborating group which will increase the information available. With this hopefully more pain management will be available including techniques for those with arthritis.
[48]
In 2020
Beth Darnall
, American scientist and pain psychologist, was appointed as scientific member of the group.
Funding
[
edit
]
Budget and politics
[
edit
]
Historical NIH budget
[49]
Year
|
Budget (millions)
|
1938
|
0.5
|
1940
|
0.7
|
1945
|
2.8
|
1950
|
52.7
|
1955
|
81.2
|
1960
|
399.4
|
1965
|
959.2
|
1970
|
1,061.0
|
1975
|
2,092.9
|
1980
|
3,428.9
|
1985
|
5,149.5
|
1990
|
7,567.4
|
1995
|
11,299.5
|
2000
|
17,840.5
|
2005
|
28,594.4
|
2010
|
31,238.0
|
2015
|
30,311.4
|
2016
|
32,311.4
|
2017
|
34,300.9
|
2018
|
37,311.3
|
2019
|
39,311.3
|
2020
|
41,690.0
|
2021
|
42,940.5
|
2022
|
45,183.0
|
2023
|
47,683.5
|
To allocate funds, the NIH must first obtain its budget from Congress. This process begins with institute and center (IC) leaders collaborating with scientists to determine the most important and promising research areas within their fields. IC leaders discuss research areas with NIH management who then develops a budget request for continuing projects, new research proposals, and new initiatives from the Director. NIH submits its budget request to the
Department of Health and Human Services
(HHS), and the HHS considers this request as a portion of its budget. Many adjustments and appeals occur between NIH and HHS before the agency submits NIH's budget request to the
Office of Management and Budget
(OMB). OMB determines what amounts and research areas are approved for incorporation into the President's final budget. The President then sends NIH's budget request to Congress in February for the next fiscal year's allocations.
[50]
The House and Senate Appropriations Subcommittees deliberate and by fall, Congress usually appropriates funding. This process takes approximately 18 months before the NIH can allocate any actual funds.
[51]
When a
government shutdown
occurs, the NIH continues to treat people who are already enrolled in
clinical trials
, but does not start any new clinical trials and does not admit new patients who are not already enrolled in a clinical trial, except for the most critically ill, as determined by the NIH Director.
[52]
[53]
[54]
[55]
Historical funding
[
edit
]
Over the last century, the responsibility to allocate funding has shifted from the OD and Advisory Committee to the individual ICs and Congress increasingly set apart funding for particular causes. In the 1970s, Congress began to earmark funds specifically for cancer research, and in the 1980s there was a significant amount allocated for AIDS/HIV research.
[56]
Funding for the NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. During the 1980s, President Reagan repeatedly tried to cut funding for research, only to see Congress partly restore funding. The political contention over NIH funding slowed the nation's response to the AIDS epidemic; while AIDS was reported in newspaper articles from 1981, no funding was provided for research on the disease. In 1984 National Cancer Institute scientists found implications that "variants of a human cancer virus called HTLV-III are the primary cause of acquired immunodeficiency syndrome (AIDS)," a new epidemic that gripped the nation.
[57]
In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research and 85 percent of all funding for health studies in universities.
[15]
From 1993 to 2001 the NIH budget doubled. For a time, funding essentially remained flat, and for seven years following the financial crisis, the NIH budget struggled to keep up with inflation.
[58]
In 1999 Congress increased the NIH's budget by $2.3 billion
[56]
to $17.2 billion in 2000.
[59]
In 2009 Congress again increased the NIH budget to $31 billion in 2010.
[59]
In 2017 and 2018, Congress passed laws with bipartisan support that substantially increasing appropriations for NIH, which was 37.3 billion dollars annually in FY2018.
[60]
[61]
Researchers at universities or other institutions outside of NIH can apply for
research project grants
(RPGs) from the NIH. There are numerous funding mechanisms for different project types (e.g., basic research, clinical research, etc.) and career stages (e.g., early career, postdoc fellowships, etc.). The NIH regularly issues "requests for applications" (RFAs), e.g., on specific programmatic priorities or timely medical problems (such as
Zika virus
research in early 2016). In addition, researchers can apply for "investigator-initiated grants" whose subject is determined by the scientist.
The total number of applicants has increased substantially, from about 60,000 investigators who had applied during the period from 1999 to 2003 to slightly less than 90,000 in who had applied during the period from 2011 to 2015.
[62]
Due to this, the "cumulative investigator rate", that is, the likelihood that unique investigators are funded over a 5-year window, has declined from 43% to 31%.
[62]
R01 grants are the most common funding mechanism and include investigator-initiated projects. The roughly 27,000 to 29,000 R01 applications had a funding success of 17-19% during 2012 though 2014. Similarly, the 13,000 to 14,000 R21 applications had a funding success of 13-14% during the same period.
[63]
In FY 2016, the total number of grant applications received by the NIH was 54,220, with approximately 19% being awarded funding.
[64]
Institutes have varying funding rates. The National Cancer Institute awarded funding to 12% of applicants, while the National Institute for General Medical Science awarded funding to 30% of applicants.
[64]
Funding criteria
[
edit
]
NIH employs five broad decision criteria in its funding policy. First, ensure the highest quality of scientific research by employing an arduous peer review process. Second, seize opportunities that have the greatest potential to yield new knowledge and that will lead to better prevention and treatment of disease. Third, maintain a diverse research portfolio in order to capitalize on major discoveries in a variety of fields such as cell biology, genetics, physics, engineering, and computer science. Fourth, address public health needs according to the disease burden (e.g., prevalence and mortality). And fifth, construct and support the scientific infrastructure (e.g., well-equipped laboratories and safe research facilities) necessary to conduct research.
[65]
Advisory committee members advise the institute on policy and procedures affecting the external research programs and provide a second level of review for all grant and cooperative agreement applications considered by the Institute for funding.
[66]
Gender and sex bias
[
edit
]
In 2014, it was announced that the NIH is directing scientists to perform their experiments with both female and male animals, or cells derived from females as well as males if they are studying cell cultures, and that the NIH would take the balance of each study design into consideration when awarding grants.
[67]
The announcement also stated that this rule would probably not apply when studying sex-specific diseases (for example, ovarian or testicular cancer).
[67]
Stakeholders
[
edit
]
General public
[
edit
]
One of the goals of the NIH is to "expand the base in medical and associated sciences in order to ensure a continued high return on the public investment in research."
[68]
Taxpayer dollars funding NIH are from the taxpayers, making them the primary beneficiaries of advances in research. Thus, the general public is a key stakeholder in the decisions resulting from the NIH funding policy.
[69]
[
failed verification
]
However, some in the general public do not feel their interests are being represented, and individuals have formed patient advocacy groups to represent their own interests.
[70]
Extramural researchers and scientists
[
edit
]
Important stakeholders of the NIH funding policy include researchers and scientists. Extramural researchers differ from intramural researchers in that they are not employed by the NIH but may apply for funding. Throughout the history of the NIH, the amount of funding received has increased, but the proportion to each IC remains relatively constant. The individual ICs then decide who will receive the grant money and how much will be allotted.
Policy changes on who receives funding significantly affect researchers. For example, the NIH has recently attempted to approve more first-time NIH R01 applicants or the research grant applications of young scientists. To encourage the participation of young scientists, the application process has been shortened and made easier.
[71]
In addition, first-time applicants are being offered more funding for their research grants than those who have received grants in the past.
[72]
Commercial partnerships
[
edit
]
In 2011 and 2012, the Department of Health and Human Services Office of Inspector General published a series of audit reports revealing that throughout the fiscal years 2000?2010, institutes under the aegis of the NIH did not comply with the time and amount requirements specified in appropriations statutes, in awarding federal contracts to commercial partners, committing the federal government to tens of millions of dollars of expenditure ahead of appropriation of funds from Congress.
[73]
Institutes and centers
[
edit
]
The NIH is composed of 27 separate institutes and centers that conduct and coordinate biomedical research.
[74]
These are:
In addition, the
National Center for Research Resources
operated from April 13, 1962, to December 23, 2011.
ARPA-H
[
edit
]
The
Advanced Research Projects Agency for Health
(ARPA-H) is an entity formerly within the Office of the
United States Secretary of Health and Human Services
, which was created by Congress in the
Consolidated Appropriations Act, 2022
.
[75]
Modeled after
DARPA
,
HSARPA
,
IARPA
, and
ARPA-E
, it is intended to pursue unconventional research projects through methods not typically used by federal agencies or private sector companies. Secretary
Xavier Becerra
delegated ARPA-H to the NIH on May 24, 2022.
[76]
[77]
[78]
It received $1 billion in appropriations in 2022, and $1.5 billion in 2023, and as of June 2023
[update]
it is requesting $2.5 billion for 2024.
[79]
[80]
Previous directors
[
edit
]
Source:
[81]
Portrait
|
Directors
|
Took office
|
Left office
|
|
Joseph J. Kinyoun
|
August 1887
|
April 30, 1899
|
|
Milton J. Rosenau
|
May 1, 1899
|
September 30, 1909
|
|
John F. Anderson
|
October 1, 1909
|
November 19, 1915
|
|
George W. McCoy
|
November 20, 1915
|
January 31, 1937
|
|
Lewis Ryers Thompson
|
February 1, 1937
|
January 31, 1942
|
|
Rolla Dyer
|
February 1, 1942
|
September 30, 1950
|
|
William H. Sebrell Jr.
|
October 1, 1950
|
July 31, 1955
|
|
James A. Shannon
|
August 1, 1955
|
August 31, 1968
|
|
Robert Q. Marston
|
September 1, 1968
|
January 21, 1973
|
|
John F. Sherman (acting)
|
January 21, 1973
|
May 28, 1973
|
|
Robert Stone
|
May 29, 1973
|
January 31, 1975
|
|
Ronald W. Lamont-Havers
(acting)
|
February 1, 1975
|
June 30, 1975
|
|
Donald S. Fredrickson
|
July 1, 1975
|
June 30, 1981
|
|
Thomas E. Malone
|
July 1, 1981
|
April 28, 1982
|
|
James Wyngaarden
|
April 29, 1982
|
July 31, 1989
|
|
William F. Raub (acting)
|
August 1, 1989
|
April 8, 1991
|
|
Bernadine Healy
|
April 9, 1991
|
July 30, 1993
|
|
Ruth L. Kirschstein
(acting)
|
July 1, 1993
|
November 22, 1993
|
|
Harold E. Varmus
|
November 23, 1993
|
December 31, 1999
|
|
Ruth L. Kirschstein
(acting)
|
January 1, 2000
|
May 2, 2002
|
|
Elias Zerhouni
|
May 2, 2002
|
October 31, 2008
|
|
Raynard S. Kington
(acting)
|
October 31, 2008
|
August 16, 2009
|
|
Francis S. Collins
|
August 17, 2009
|
December 19, 2021
|
|
Lawrence A. Tabak
(acting)
|
December 20, 2021
|
November 8, 2023
|
|
Monica Bertagnolli
|
November 9, 2023
|
Present
|
See also
[
edit
]
References
[
edit
]
- ^
"Organization and Leadership | NIH Intramural Research Program"
. Irp.nih.gov. April 4, 2011.
Archived
from the original on April 24, 2013
. Retrieved
April 28,
2013
.
- ^
Osterweil, Neil (September 20, 2005).
"Medical Research Spending Doubled Over Past Decade"
.
MedPage Today
.
Archived
from the original on October 16, 2015
. Retrieved
September 15,
2015
.
- ^
"NIH Intramural Research at the Threshold of a New Era"
(PDF)
.
NIH Sourcebook
. Archived from
the original
(PDF)
on January 5, 2012
. Retrieved
January 20,
2012
.
- ^
"The top 10 institutions in biomedical sciences in 2018"
.
Nature Index
. May 17, 2019
. Retrieved
May 28,
2019
.
- ^
"Introduction to the Nature Index"
.
Nature Index
.
- ^
Harden, Victoria A.
"WWI and the Ransdell Act of 1930"
.
A Short History of the National Institutes of Health
. Office Of History National Institutes Of Health.
Archived
from the original on September 7, 2011
. Retrieved
September 12,
2011
.
- ^
"A Short History of the National Institutes of Health (1 of 13)"
. history.nih.gov.
Archived
from the original on May 15, 2011
. Retrieved
May 25,
2011
.
- ^
"SIC 9431 Administration of Public Health Programs"
. Referenceforbusiness.com.
Archived
from the original on May 10, 2011
. Retrieved
May 25,
2011
.
- ^
a
b
c
d
e
f
NIH Almanac 2011
,
History: Chronology of Events: 1800?
harvnb error: no target: CITEREFNIH_Almanac2011 (
help
)
- ^
Harden, Victoria A.; Lyons, Michele (February 27, 2018).
"NIH's Early Homes"
.
NIH Intramural Research Program
. Retrieved
December 13,
2020
.
- ^
a
b
"Records of the Public Health Service [PHS], 1912-1968"
.
National Archives
. August 15, 2016
. Retrieved
April 23,
2021
.
- ^
Doyle, Henry N. (1977).
"The federal industrial hygiene agency: a history of the Division of Occupational Health, United States Public Health Service"
(PDF)
.
American Conference of Governmental Industrial Hygienists
.
Archived
(PDF)
from the original on October 13, 2021
. Retrieved
September 3,
2020
.
- ^
a
b
c
d
Skloot, Rebecca (2010).
The Immortal Life of Henrietta Lacks
. New York: Broadway Paperbacks.
- ^
"History of the National Cancer Institute"
. National Cancer Institute – National Institutes of Health. March 18, 2015.
Archived
from the original on June 28, 2017
. Retrieved
June 29,
2017
.
- ^
a
b
Laurie J. Price (1992). "A Medical Anthropologist's Ruminations on NIH Funding".
Medical Anthropology Quarterly
. New Series.
6
(2): 128?146.
doi
:
10.1525/maq.1992.6.2.02a00030
.
JSTOR
649307
.
- ^
"Historical Trends in Federal R&D"
.
AAAS - The World's Largest General Scientific Society
. June 11, 2013.
Archived
from the original on January 10, 2018.
- ^
"Online Education Kit: 1990: Launch of the Human Genome Project"
.
National Human Genome Research Institute (NHGRI)
. Retrieved
November 26,
2018
.
- ^
"NIH Leadership"
.
National Institutes of Health (NIH)
. October 31, 2014
. Retrieved
March 18,
2019
.
This article incorporates text from this source, which is in the
public domain
.
- ^
"Kathryn M. Partin, Ph.D."
National Institutes of Health. May 27, 2021.
- ^
"Division of Extramural Activities - Contacts"
. National Institutes of Health. May 28, 2021.
- ^
"Office of Ethics (OE) - Contacts"
. National Institutes of Health. June 17, 2009.
- ^
"Global Research - Contacts"
. National Institutes of Health. April 26, 2021.
- ^
"Bayview Campus"
.
nih.gov
. May 8, 2013.
Archived
from the original on September 5, 2017
. Retrieved
May 7,
2018
.
- ^
"NCI at Frederick: About the NCI at Frederick"
.
ncifrederick.cancer.gov
.
Archived
from the original on January 10, 2018.
- ^
"Division of Intramural Research Overview"
. National Institute of Allergy and Infectious Diseases. September 1, 2010. Archived from
the original
on March 8, 2010
. Retrieved
September 15,
2015
.
- ^
"Lasker Awards"
.
National Institutes of Health (NIH)
. February 5, 2016.
Archived
from the original on July 5, 2016.
- ^
a
b
Philippidis, Alex (September 2019).
"Top 25 NIH-Funded Institutions"
.
Genetic Engineering & Biotechnology News
. Vol. 39, no. 9. p. 16
. Retrieved
September 14,
2019
.
- ^
Garland, Eva (2014).
Winning SBIR/STTR Grants: A Ten Week Plan for Preparing Your NIH Phase I Application
. CreateSpace Independent Publishing Platform.
ISBN
978-1494784447
.
- ^
"NIH Budget"
.
National Institutes of Health
. May 23, 2011.
Archived
from the original on August 26, 2011
. Retrieved
August 26,
2011
.
- ^
"Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC)"
.
Research Portfolio Online Reporting Tools
. National Institutes of Health. March 15, 2011. Archived from
the original
on August 13, 2011
. Retrieved
August 26,
2011
.
- ^
National Institutes of Health.
"NIH Public Access Policy Details"
. National Institutes of Health. Archived from
the original
on November 1, 2011
. Retrieved
January 30,
2014
.
- ^
Suber, Peter (April 16, 2008).
"An open access mandate for the National Institutes of Health"
.
Open Medicine
.
2
(2): e39?41.
PMC
3090178
.
PMID
21602938
.
- ^
"The Benefits of Medical Research and the Role of the NIH"
(PDF)
. U.S. Joint Economic Committee. May 2000. Archived from
the original
(PDF)
on April 12, 2015
. Retrieved
May 25,
2011
.
- ^
Stevens, A. J.; Jensen, J. J.; Wyller, K.; Kilgore, P. C.; Chatterjee, S.; Rohrbaugh, M. L. (2011).
"The Role of Public-Sector Research in the Discovery of Drugs and Vaccines"
.
New England Journal of Medicine
.
364
(6): 535?541.
doi
:
10.1056/NEJMsa1008268
.
PMID
21306239
.
- ^
"NIH funding contributed to 210 approved drugs in recent years, study says"
.
statnews.com
. February 12, 2018.
Archived
from the original on March 22, 2018
. Retrieved
May 7,
2018
.
- ^
Azoulay, Pierre; Graff Zivin, Joshua S.; Li, Danielle; Sampat, Bhaven N. (January 2015).
"Public R&D Investments and Private-sector Patenting: Evidence from NIH Funding Rules"
.
NBER Working Paper No. 20889
.
doi
:
10.3386/w20889
.
- ^
Tryka, K. A.; Hao, L.; Sturcke, A.; Jin, Y.; Wang, Z. Y.; Ziyabari, L.; Lee, M.; Popova, N.; Sharopova, N.; Kimura, M.; Feolo, M. (January 1, 2014).
"NCBI's Database of Genotypes and Phenotypes: dbGaP"
.
Nucleic Acids Research
.
42
(D975?D979): D975?D979.
doi
:
10.1093/nar/gkt1211
.
PMC
3965052
.
PMID
24297256
.
- ^
Lee, James (October 19, 2022).
"Don't Even Go There"
. City Journal
. Retrieved
January 10,
2023
.
- ^
Palca, Joe (July 27, 2020).
"COVID-19 Vaccine Candidate Heads To Widespread Testing In U.S."
NPR
.
- ^
Staff Writer (November 16, 2020).
"Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine"
.
National Institutes of Health
. U.S. Department of Health and Human Services
. Retrieved
June 23,
2021
.
- ^
"2021 Statutory Report"
(PDF)
.
Foundation for the National Institutes of Health
. May 2022.
Archived
(PDF)
from the original on September 16, 2022
. Retrieved
September 15,
2022
.
- ^
"Fauci Was 'Untruthful' to Congress About Wuhan Lab Research, New Documents Appear To Show"
.
Newsweek
. September 9, 2021.
- ^
"Wuhan, U.S. Scientists Planned to Make Coronaviruses, Documents Leaked by DRASTIC Show"
.
Newsweek
. October 8, 2021.
- ^
"In Major Shift, NIH Admits Funding Risky Virus Research in Wuhan"
.
Vanity Fair
. October 22, 2021.
- ^
"NIH says grantee failed to report experiment in Wuhan that created a bat virus that made mice sicker"
.
Science
. October 21, 2021.
- ^
"Fauci stands by gain-of-function research denials, defends collaboration with Wuhan lab"
.
The Denver Gazette
. October 24, 2021.
- ^
"NIH Presses U.S. Nonprofit for Information on Wuhan Virology Lab"
. Wall Street Journal
. Retrieved
June 6,
2021
.
- ^
"Members of new Interagency Pain Research Coordinating Committee announced"
.
nih.gov
. February 13, 2012
. Retrieved
July 13,
2019
.
- ^
"Appropriations"
.
National Institutes of Health (NIH)
. Retrieved
January 27,
2024
.
- ^
"Funding"
(PDF)
.
Archived
(PDF)
from the original on March 4, 2016.
- ^
"Funding"
.
Archived
from the original on December 7, 2011.
- ^
Sabrina Tavernese (October 9, 2013).
"Clinical Trials Continue, but Only at a Crawl"
.
New York Times
.
Archived
from the original on November 4, 2017.
- ^
Neergaard, Lauran (October 9, 2013).
"NIH admits a dozen critically ill, making exceptions to no-new-patient policy during shutdown"
.
Huffington Post
.
The Associated Press
.
Archived
from the original on March 1, 2017
. Retrieved
September 10,
2015
.
- ^
"Government slimdown blocks some seeking NIH research treatment"
.
Fox News Channel
. The Associated Press. October 2, 2013.
Archived
from the original on October 5, 2013.
- ^
"Department of Health and Human Services Fiscal Year 2014 Contingency Staffing Plan for Operations in the Absence of Enacted Annual Appropriations"
(PDF)
. Archived from
the original
(PDF)
on October 28, 2013.
- ^
a
b
NIH Almanac 2011
,
History: Legislative Chronology: Funding
harvnb error: no target: CITEREFNIH_Almanac2011 (
help
)
- ^
NIH Almanac 2011
,
History: Chronology of Events: 1980?
harvnb error: no target: CITEREFNIH_Almanac2011 (
help
)
- ^
NIH Appropriations (Section 1)
Archived
May 7, 2017, at the
Wayback Machine
and
NIH Appropriations (Section 2)
Archived
January 5, 2018, at the
Wayback Machine
April 7, 2016, retrieved May 4, 2016, U.S. Department of Health and Human Service
- ^
a
b
"Funding"
(PDF)
.
Archived
(PDF)
from the original on February 15, 2013.
- ^
Office of Management and Budget
America First. A Budget Blueprint to Make America Great Again.
Archived
May 4, 2017, at the
Wayback Machine
Budget of the United States Government, Fiscal Year 2018. Government Publishing Office, March 16, 2017.65 pp
- ^
"NIH Funding: FY1994-FY2019"
(PDF)
.
Congressional Research Service
.
Archived
(PDF)
from the original on March 28, 2014
. Retrieved
March 17,
2017
.
- ^
a
b
Lauer, Mike (May 31, 2016).
"How Many Researchers?"
.
Open Mike
. NIH.
Archived
from the original on August 25, 2016
. Retrieved
June 6,
2016
.
- ^
Rockey, Sally (April 10, 2015).
"Looking at Recent Data on R21 and R01-equivalent Grants"
.
Rock Talk
. NIH.
Archived
from the original on October 8, 2016
. Retrieved
October 2,
2016
.
- ^
a
b
"NIH Research Portfolio Online Reporting Tools (RePORT)"
.
report.nih.gov
.
Archived
from the original on February 2, 2018.
- ^
"Statement on Funding Allocation for Disease Research by Harold Varmus, M. D., Director, National Institutes of Health"
. Assistant Secretary for Legislation, Department of Health and Human Services. May 6, 1999.
- ^
"National Advisory Neurological Disorders and Stroke Council (NANDSC)"
. Ninds.nih.gov.
Archived
from the original on April 28, 2013
. Retrieved
April 28,
2013
.
- ^
a
b
Rabin, Roni Caryn (May 14, 2014).
"Labs Are Told to Start Including a Neglected Variable: Females"
.
The New York Times
.
Archived
from the original on September 6, 2015
. Retrieved
September 10,
2015
.
- ^
"Stakeholders"
. October 31, 2014.
Archived
from the original on November 25, 2011.
- ^
"Stakeholders"
. Archived from
the original
on November 14, 2011.
- ^
"Stakeholders"
.
Archived
from the original on November 4, 2016.
- ^
Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE (2008). "Changes to NIH grant system may backfire".
Science
.
322
(5905): 1187?8.
doi
:
10.1126/science.322.5905.1187c
.
PMID
19023064
.
S2CID
47509185
.
- ^
Costello LC (May 2010).
"Perspective: is NIH funding the "best science by the best scientists"? A critique of the NIH R01 research grant review policies"
.
Acad Med
.
85
(5): 775?9.
doi
:
10.1097/ACM.0b013e3181d74256
.
PMID
20520024
.
- ^
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-15416 With the University of California at San Francisco Audit (A-03-10-03120)"
(PDF)
. June 2011.
Archived
(PDF)
from the original on October 15, 2011
. Retrieved
June 25,
2011
.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-3-0052 With Avecia Biologics Limited"
(PDF)
. September 2011.
Archived
(PDF)
from the original on October 15, 2011
. Retrieved
October 9,
2011
.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN266-2006-00015C With NexBio, Inc"
(PDF)
. September 2011.
Archived
(PDF)
from the original on October 15, 2011
. Retrieved
October 9,
2011
.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN272-2008-00013C with the EMMES Corporation (A-03-10-03115)"
(PDF)
. October 2011.
Archived
(PDF)
from the original on June 2, 2013
. Retrieved
September 11,
2011
.
"Appropriations Funding for Eunice Kennedy Shriver National Institute of Child Health and Human Development Contract HHSN275-03-3345 With Westat, Inc. Audit (A-03-10-03106)"
(PDF)
. October 2011.
Archived
(PDF)
from the original on June 1, 2013
. Retrieved
November 20,
2011
.
"Appropriations Funding for National Institute on Drug Abuse Contract HHSN271-2007-00009C with Charles River Laboratories, Inc. (A-03-10-03104)"
(PDF)
. October 2011.
Archived
(PDF)
from the original on June 2, 2013
. Retrieved
November 22,
2011
.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN266-2005-00022C With PPD Development, LP (Audit A-03-10-03118)"
(PDF)
. September 2012.
Archived
(PDF)
from the original on May 22, 2013
. Retrieved
September 26,
2012
.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-30068 With PPD Development, LP (Audit A-03-10-03116)"
(PDF)
. September 2012.
Archived
(PDF)
from the original on May 22, 2013
. Retrieved
September 26,
2011
.
- ^
"List of Institutes and Centers"
.
National Institutes of Health
. April 14, 2015
. Retrieved
April 15,
2024
.
- ^
Pub. L.
Tooltip Public Law (United States)
117?103: Consolidated Appropriations Act, 2022 (text)
(PDF)
- ^
87
FR
32174
- ^
"Russell Named Acting Deputy Director for New Advanced Research Entity"
.
NIH Record
. June 10, 2022
. Retrieved
June 14,
2023
.
- ^
Mesa, Natalie (April 1, 2022).
"ARPA-H to Be Within NIH but Independently Managed by HHS"
.
The Scientist Magazine
. Retrieved
June 14,
2023
.
- ^
"Budget and Appropriations"
.
ARPA-H
. Retrieved
June 14,
2023
.
- ^
Kozlov, Max (June 14, 2022).
"Billion-dollar US health agency gets new chief ? but its direction remains in limbo"
.
Nature
. Retrieved
September 14,
2022
.
- ^
"The NIH Directors"
. National Institutes of Health. February 11, 2015.
Archived
from the original on June 1, 2013.
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