??????????

??????????
????? ???????
	3-Acetamidopropane-1-sulfonic acid
???????? ??????
??? ??????? ????? ?????	C ( US ) B2 ( AU )
??? ????? ??????	Oral (333mg tablets of acamprosate calcium)
?????? ??????
????? ????	11%
??? ???????	Negligible
??????? (???) ??????	Nil
??? ????? ??????	20 to 33 ???? (????)s
????? (?????)	????
???????
CAS	77337-76-9
? ? ?	N07 N07BB03 BB03
??? ???	CID 155434
ECHA InfoCard ID	100.071.495
??? ???	APRD00661
??? ??????	136929
?????? ??????	N4K14YGM3J
?????	D07058
ChEMBL	CHEMBL1201293
?????? ????????
?????? ??????????	C 5 H 11 N O 4 S
?????? ????????	181.211 g/mol
	?????? ??????? ????? ????? ??????? ??????
	?????? ????????? ??????
	????? ????? - ?????

?????????? ? ???????? ????? ?????? ??????? ??????? ? ?? ??? ??????? ???? ?????? ????? ????? ??????.

???? ???? ???????????? ??? ???? ??????? ????????? ?? ?????? ???? ???? ???? ????? ??????? ???? ?? ???? ??? ???????? N-methyl-D-Aspartate ????????????? ?? ????? ???? ???? ??? ???????? gamma-aminobutyric acid (GABA) ????? ?. [1] ???? ???????? ??? ?? ?????????? ???? ??? ?? ???? ???? ??????? ????? ?????? ?????? ???????? ???????? ??? ???????? ????? ?? ????? ?????? .[2] ??? ?????? ???????? ??????? ???? ???? ?? ??? ????? ?? ?????? (??????)? ??? ?????? ????? ?????? ??????? ?? ?????? ??? ???? ? ?? ??? ?? ?????? ???????? ????? ????? ???? ?????? ? ????? ? ?????? ??????. [4] ?? ????? ????? (??????????) ?? ??? ??????? ????? ?????? ?? ????? ?? ????? ?? ????? ?????? ??????. [6]

????? ??????? ????? ????? ?????? ??????? ?? ???????? ???????? ????? ?????? ???? ???? ???? ???????? ???????. ???? ??????? ????? ???? 333 ??? ?? ???? ??????? ????????????? ??? ?? ????? 300 ??? ?? ????????????? ??? ???? ??? ???? ????? ????? ????? ??????? . [8]

???????? [ ??? ]

??? ?? ????? ?????? ??????? (FDA) ?? ???????? ??????? ????? ??? ??? ?????? ?? ???? / ????? 2004? ??? ??? ?????? ???????? ????????? ?? ?????? ??? ??? 1989. ??? ?? ????? ??? ??????? ????? ????? ??????? ????????? ??? ??????:

≪??? ????? ?? ???? ???? ???? ?????? ??????? ???? ?? ??????? ?? ??????? ???? ??? ???????? ??????? ?? ?????? ? ??????? ?????? ??????. ???? ??????? ??? ??? ????? ??? ?????? ?????? ?????? ?????? ????? ??????? ?? ????? ?????? ????? ?????? ?? ??????. ??? ??????? ?????? ??? ??? ?? ?????? ??? ????? (??? ?????? ?? ????? ??????)? ??? ???? ?? ???? ???? ?? ???????? ?????????? ???????? ???? ???? ??????? ???? ????? ??? ????? ??? ??? ?????? ?? ???? ????? ??????. ??????? ??????? ???? ????? ???? ??? ??? ?? ??????? ????????. ???? ??????? ??????? ????? ????? ?????? ?????? ?? ??????? ???? ?????? ? ???????? ? ??????? ????? ? ????????. ≫ ^[3]

????? ??????? [ ??? ]

???? ?????? ?????? ???? ????? ????? ?????? ??????? ?????? ??? ??????? ?????????? ???? ????????? ?? ?????? ??????. ????? ???? ??????? ??????? ????? ?????? ??????? ?????? ??????? ?? ??????. ???? ???????? ?? ?????????? ?? ≪????≫ ????. ^[4]

??? ????? ??? ????? ??? ??? ?????? ??????? ???????? ?? ??????? ?????? ??????? ??????????? ????????????? ???? ?? ???? ?? ???????? ??? ????? ?? ???????? ????? 12. ^[5] ?? 59 ????? ?? ?????? ???? ??????? ?? ?????? ??????? ???????? ?? ?????? ?? ?? ??? ?? ????? ???????? ??????? ???? ???????. ???? ??????? ?????.

! ! ???? ???? ?????? ! ?????? ???????? ?? ?????? ????? ! ????? ??? ???? ???????? ?? ?????? ????? ¹ ! ???? ??? ??? ??? ???????? ¹ | -- | ?????????? ???????? | 66.1 ? | 50.8 ? | 45.07 ???? | 26.79 ???? | -- | ???????????? ???????? | 79.7 ? | 66.1 ? | 49.95 ???? | 26.7 ???? | -- | ?????? ?????? ?????? | 83.1 ? | 67.8 ? | 53.58 ???? | 37.32 ???? |)

¹ ??? ????????? ????? ??? ?????? ????? ?? ??????? ?? ?????? ??????? ???? ???? 84 ???? ???????.

????? ??? ??????? ??? ?? ????? ?? ??????? ???? ???? ???? ?????? ?????? ?? ????? ???? ?? ??????? ??? ???????? ?????.

????????? ????? [ ??? ]

?????? ???? ???? ???????? ????????????? ????? ???? (???????? ?-?????-?-?????????) ?????????? ?? ?? ?-?-?-?-?? ??? ?? ??????? ?????? ?????? ???? ??? ??????? ?? ??? ??? ??????????. ?????? ???? ???????? ?????? ???? ??? ??????? ?????? ???? ?-?-?-?-? ?? ???? ???? ????? ?? ???????? ?????? ??????? ??????? ????????? ???? ??????? ??????? ???????? ?????? ???????. ^[6] ???????? ?? ?????? ???? ????? ?? ??????? ?? ???? ???? ???? ???? ??????????? ???? ???? ?? ?-?-?-?-?. ^[7] ?????????? ???? ?? ??? ?????? ??????????. ^[8] ???????? ??? ???? ??????? ????????? ?? ????? ?????? ??????? ??????? ?? ?????? ?????????. ^[9]? ??????? ?????????? ?????? ?? ?????? ?????????. ^[10]

??????? ??????? ??????? [ ??? ]

????????? ??? ?? ???? ?? ?????? ??? ?????? ?????? ??? ???????? ?? ?????? ???? ?????? ???? ??? ?? ?????????? ??????????????? (?? ??? ???? ??????? ??????? ?? ????? ???????? ??????? ?? ??????? ?????? ?????? ?????? ?? ????????? ????). ^[8] ??? ???? ??????? ???? ?????????? ???? ???? ??????? ?? ????? ??? ??????? ??????? ?? ??? ???? ?????? (??? ????? ???? ????). ^[11] ????? ??? ???????? ???? ?????? ????? ?? ??? ?? ?????? ?????? ?? ??? ???? ???? ?????????? ??? ???? ??? ????? ????? ???? ??????? (????? ???? ?????? ?????????? ??????????. ^[12]

??????? [ ??? ]

^ ^? ^? ^? ^? ^? ^? ^? "Campral Description" (PDF) . 18 ???? 2006. ????? ?? ????? (pdf) ?? 2023-03-15 . ???? ???? ?????? 2 ????? 2006 . {{ ??????? ??? }}: ???? ?? ??????? ??: |????? ??????= ( ?????? )
^ Acamprosate (???????????), QID : Q278487
^ "FDA Approves New Drug for Treatment of Alcoholism" . FDA Talk Paper . ????? ?????? ??????? . 29 ????? 2004. ????? ?? ????? ?? 2008-01-17 . ???? ???? ?????? 2009-08-15 .
^ Mason? BJ (2006). "Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: The role of patient motivation" . J Psychiatr Res . ?. 40 ?. 5: 383?393. DOI : 10.1016/j.jpsychires.2006.02.002 . PMID : 16546214 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )
^ Feeney? GF (2006). "Combined acamprosate and naltrexone, with cognitive behavioural therapy is superior to either medication alone for alcohol abstinence: A single centre's experience with pharmacotherapy". Alcohol Alcohol . ?. 41 ?. 3: 321?327. DOI : 10.1093/alcalc/agl007 . PMID : 16467406 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )
^ ?? ????? ? ? ????. 1998. ??? ?????? ???????????? ?? ?????????? ??? ???????. ????????? ?????? ????? 49 : 173-184. ???? 9509257. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.
^ ???? ???? ????? ???????? ? ?????? ????? ?? ? ??? ?????? ???????? ? ? ????. (1998). "???????????? ?????? ?????? ??????? ??? ?????? ??????". ??????? ????????? ???? ?????? ? 155 (6) : 726-732. ???? 9619143. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009. "???? ??????" . ????? ?? ????? ?? 2011-09-27 . ???? ???? ?????? 2010-10-16 . {{ ??????? ??? }}: ????? ?????????: BOT: original URL status unknown ( link )
^ ^? ^? ?? ??? ?? ? ???????? ? ?????? ??? ?. (2005). "??????????????? ????????? ????? ???? ?????????? : ????? ???? ?????". ????? ?????? ?????? ??????? 19 (6) : 517-537. ???? 15963001. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.
^ ?? ????? ?. ?????? ?? ??????? ?. ????????? ??????? ????????? ?????? ?????? ?????? ??????? J. (2002). "?????????? ? ??? ??????? - 801? ??????????? ???? ???? ????????? ???????? ??????? ?? ?????? ????????? ?? ???????? ?? ??? ???? ????? ????? ?????? ??????? ????? ???????". ??????? ??? ??????? ??????? ???????? ????????? ? 26 (10) : 1468-1478. ???? 12394279. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.
^ ? ???? ??????? ????????? ? ??? ???? ?????? ??????? J. (2001) "?????????? ?? ??????????????? ?? ?????????? ???? ?????? ????? ?????? ??????? ????? ????? ?????? ????????? ?? ???????? ????? ?????? ?? ???? ??????? ????????". ??????? ??? ??????? ??????? ???????? ????????? 25 (9) : 1276-1283. ???? 11584146. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.
^ Engelhard? K (2006). "The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e". Anaesthesist . ?. 49 ?. 9: 816?821. PMID : 11076270 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )
^ Adde-Michel? C (2005). "Effect of acamprosate on neonatal excitotoxic cortical lesions in in utero alcohol-exposed hamsters". Neuroscience Letters . ?. 374 ?. 2: 109?112. DOI : 10.1016/j.neulet.2004.10.037 . PMID : 15644274 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )

????:Drugs used in addictive disorders

????? ??????? ????

?????????? ?? ???????? ??????? :

??? ?????? ????? ?? ?????.

[fda-1] ? ^? ^? ^? ^? ^? ^? "Campral Description" (PDF) . 18 ???? 2006. ????? ?? ????? (pdf) ?? 2023-03-15 . ???? ???? ?????? 2 ????? 2006 . {{ ??????? ??? }}: ???? ?? ??????? ??: |????? ??????= ( ?????? )

[wikidata-9ef411ccfb7ae85f2b4f5a14b9126cc71a42ef31-2] Acamprosate (???????????), QID : Q278487

[3] "FDA Approves New Drug for Treatment of Alcoholism" . FDA Talk Paper . ????? ?????? ??????? . 29 ????? 2004. ????? ?? ????? ?? 2008-01-17 . ???? ???? ?????? 2009-08-15 .

[Mason2006-4] Mason? BJ (2006). "Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: The role of patient motivation" . J Psychiatr Res . ?. 40 ?. 5: 383?393. DOI : 10.1016/j.jpsychires.2006.02.002 . PMID : 16546214 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )

[5] Feeney? GF (2006). "Combined acamprosate and naltrexone, with cognitive behavioural therapy is superior to either medication alone for alcohol abstinence: A single centre's experience with pharmacotherapy". Alcohol Alcohol . ?. 41 ?. 3: 321?327. DOI : 10.1093/alcalc/agl007 . PMID : 16467406 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )

[6] ?? ????? ? ? ????. 1998. ??? ?????? ???????????? ?? ?????????? ??? ???????. ????????? ?????? ????? 49 : 173-184. ???? 9509257. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.

[7] ???? ???? ????? ???????? ? ?????? ????? ?? ? ??? ?????? ???????? ? ? ????. (1998). "???????????? ?????? ?????? ??????? ??? ?????? ??????". ??????? ????????? ???? ?????? ? 155 (6) : 726-732. ???? 9619143. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009. "???? ??????" . ????? ?? ????? ?? 2011-09-27 . ???? ???? ?????? 2010-10-16 . {{ ??????? ??? }}: ????? ?????????: BOT: original URL status unknown ( link )

[De_Witte_2005-8] ? ^? ?? ??? ?? ? ???????? ? ?????? ??? ?. (2005). "??????????????? ????????? ????? ???? ?????????? : ????? ???? ?????". ????? ?????? ?????? ??????? 19 (6) : 517-537. ???? 15963001. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.

[9] ?? ????? ?. ?????? ?? ??????? ?. ????????? ??????? ????????? ?????? ?????? ?????? ??????? J. (2002). "?????????? ? ??? ??????? - 801? ??????????? ???? ???? ????????? ???????? ??????? ?? ?????? ????????? ?? ???????? ?? ??? ???? ????? ????? ?????? ??????? ????? ???????". ??????? ??? ??????? ??????? ???????? ????????? ? 26 (10) : 1468-1478. ???? 12394279. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.

[10] ? ???? ??????? ????????? ? ??? ???? ?????? ??????? J. (2001) "?????????? ?? ??????????????? ?? ?????????? ???? ?????? ????? ?????? ??????? ????? ????? ?????? ????????? ?? ???????? ????? ?????? ?? ???? ??????? ????????". ??????? ??? ??????? ??????? ???????? ????????? 25 (9) : 1276-1283. ???? 11584146. ?? ???????? ?? ?????? ??? ?? ??? ????? 2009.

[Engelhard2006-11] Engelhard? K (2006). "The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e". Anaesthesist . ?. 49 ?. 9: 816?821. PMID : 11076270 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )

[Adde2005-12] Adde-Michel? C (2005). "Effect of acamprosate on neonatal excitotoxic cortical lesions in in utero alcohol-exposed hamsters". Neuroscience Letters . ?. 374 ?. 2: 109?112. DOI : 10.1016/j.neulet.2004.10.037 . PMID : 15644274 . {{ ??????? ?????? ????? }}: ?????? author-name-list parameters ???? ???? ?? ??? ( ?????? )

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