One, two and finally three ? contained quite neatly in a span of 19 minutes. A dazzling display for Lionel Messi on a warm Friday night in Chicago.

Once Argentina introduced Messi into the game, it was all over for Panama.

Messi scored three second-half goals in his return from a back injury, and Argentina clinched a spot in the knockout round of the Copa America Centenario with a 5-0 victory over an overwhelmed Panama team weakened by a flood of yellow cards.

“Happy, happy to be back, to be able to play after resting for some time,” Messi said. “I really wanted to play, for the outcome, for the goals. Very happy, to be honest.”

Messi replaced Augusto Fernandez in the 61st minute, drawing a big ovation from a sea of No10 Argentina jerseys and the familiar colors of Barcelona. A few minutes later, the five-time Fifa world player of the year got right back to work.

First, Roderick Miller’s clearing attempt for Panama went off Gonzalo Higuain’s hands as he went to protect his face and right to Messi, who beat Jaime Penedo to the goalie’s right side. Then Messi sent a curling free kick from about 24 yards into the top corner in the 78th minute, making it 3-0 and drawing gasps from the crowd of 53,885 at the home of the Chicago Bears.

A left-footed chip past Penedo finished off Messi’s fourth international hat- trick, joining friendlies against Switzerland and Brazil in 2012, and Guatemala in 2013. It also ran Messi’s total to 53 international goals, just three away from Gabriel Batistuta’s Argentine’s record.

“When Messi got up, I asked the fourth referee, ‘How much time left,” Panama manager Hernan Dario Gomez said. “Thirty minutes,’ and we were already spent. Messi is a monster.”

It was quite a show after Messi departed in the second half of a 1-0 victory against Honduras on May 27 with a back and rib injury. He also missed Argentina’s 2-1 victory over Chile in the Copa opener, but manager Gerardo Martino said Thursday he was training with the team and ready to go against Panama.

No kidding.

Nicolas Otamendi scored with a header from an Angel Di Maria in the seventh minute, and Sergio Aguero made it 5-0 in the 90th minute. Di Maria was examined by doctors after he left with an injury right before half-time, but Martino can afford to be cautious with Argentina already through to the quarter-finals before their final Group D game Thursday night against Bolivia in Seattle.

“Most of all I think that we need to respond to the situation of some players that have yellow cards … how to make some changes without altering the structure of the team,” Martino said.

Panama can advance to the next round with a victory over Chile on Thursday night in Philadelphia, but they will be without key forward Blas Perez, defender Felipe Baloy and midfielders Armando Cooper and Anibal Godoy, after the team was whistled for six yellow cards. Midfielder Valentin Pimentel was carried off on a stretcher in the 20th minute.

A rare US appearance for Messi attracted a mostly blue-and-white-clad crowd that easily cruised past the attendance of 39,642 for the United States’ 4-0 victory against Costa Rica on Tuesday night. The fans chanted “Messi! Messi!” at a couple of points in the first half and cheered loudly whenever he was shown on the videoboard.

Two fans stormed the field after the game to try to get to Messi, but each was tackled by security.

“The truth is [I’m] very grateful, especially with the people today that once again treated me spectacularly,” Messi said. “Not just me, but all the team, just like the first time I came to the US, so very happy and grateful.”

In between a steady stream of first-half whistles and yellow cards, top-ranked Argentina showed off some of the play that makes them one of the favorites to take home South America’s championship. Otamendi’s well-placed header was enough for a 1-0 lead at the break.

Panama competed hard, but played with 10 men after Godoy received his second yellow in the 31st minute. Chasing Argentina around with one less player got even more daunting when Messi trotted on the field in the second half.

“When Messi came in, things were taken of,” Martino said.