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Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder

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Abstract

Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE 1 -stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha 2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT 1a -like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.

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References

  • Beck AT, Wand CH, Mendelson M, Mock J, Ernbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:53?59

    Google Scholar  

  • Charney DS, Innis RB, Duman RS, Woods SW, Heninger GR (1989) Platelet alpha-2 receptor binding and adenylate cyclase activity in panic disorder. Psychopharmacology 98:102?107

    Google Scholar  

  • Fetter S, Lewis GN, Gronlund L (1993) Why were Scud casualties so low? Nature 361:293?296

    Google Scholar  

  • Garcia-Sevilla JA, Padro D, Giralt T, Guimon J, Areso P (1990) Alpha-2 adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Arch Gen Psychiatry 47:125?132

    Google Scholar  

  • Kanof PD, Johns C, Davidson M, Siever LJ, Coccaro EF, Davis KL (1986) Prostaglandin receptor sensitivity in psychiatric disorders. Arch Gen Psychiatry 43:987?993

    Google Scholar  

  • Lerer B, Ebstein RP, Sheshatsky M, Shemesh Z, Greenberg DA (1987) Cyclic AMP signal transduction in post-traumatic stress disorder. Am J Psychiatry 144:1324?1327

    Google Scholar  

  • Lerer B, Bleich A, Bennett ER, Ebstein RP, Balkin J (1990) Platelet adenylate cyclase and phospholipase C activity in post-traumatic stress disorder. Biol Psychiatry 27:735?740

    Google Scholar  

  • Newman ME, Lerer B, Lichtenberg P, Shapira B (1992) Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function. Psychopharmacology 109:231?234

    Google Scholar  

  • Perry BD, Southwick SM, Giller EJ (1987) Altered platelet alpha-2 adrenergic binding sites in post-traumatic stress disorder. Am J Psychiatry 144:1511?1512

    Google Scholar  

  • Piletz JE, Schubert DSP, Halaris A (1986) Evaluation of studies on platelet alpha-2 adrenoreceptors in depressive illness. Life Sci 39:1589?1616

    Google Scholar  

  • Piletz JE, Halaris A, Saran A, Marler MR (1991) Desipramine lowers tritiated para-aminoclonidine binding in platelets of depressed patients. Arch Gen Psychiary 48:813?820

    Google Scholar  

  • Sierles FS, Chen JJ, McFarlane RE, Taylor MA (1983) Posttraumatic stress disorder and concurrent psychiatric illness; a preliminary report. Am J Psychiatry 140:1177?1179

    Google Scholar  

  • Siever LJ, Kafka MS, Targum S, Lake CR (1984) Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls. Psychiatry Res 11:287?302

    Google Scholar  

  • Solomon Z, Benbenisti R, Neria Y, Abramowitz M, Ginzburg K, Ohry A (1993) Assessment of PTSD: Validation of the revised PTSD inventory. Isr J Psychiatry, 30:110?115

    Google Scholar  

  • Spielberger CD, Borusch RL, Lushene RE (1977): Manual of the State Trait Anxiety Inventory. Consulting Psychologist Press, Palo Alto, California

    Google Scholar  

  • Spitzer RL, Williams JBW, Gibbon M, First MB (1989) Structured clinical interview for DSM-III-R patient edition (SCID-P). Biometrics Research Department, New York State Psychiatric Institute, New York

    Google Scholar  

  • Zilberg NJ, Weiss DS, Horowitz MJ (1982) Impact of Events scale: a cross-validation study and some empirical evidence supporting a conceptual model of stress resistant syndromes. J Consult Clin Psychol 50:407?410

    Google Scholar  

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Authors and Affiliations

  1. Tel Aviv Community Mental Health Center and Sackler Faculty of Medicine, Tel Aviv, Israel

    Ronit Weizmann,?Nathaniel Laor,?Ahuva Reiss?&?Uri Muller

  2. Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

    Eitan Gur,?Bernard Lerer?&?Michael E. Newman

  3. Yale Child Study Center, USA

    Nathaniel Laor

  4. Pardesia Hospital, Netanya, Israel

    Alexander Yoresh

Authors
  1. Ronit Weizmann
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  2. Eitan Gur
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  3. Nathaniel Laor
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  4. Ahuva Reiss
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  5. Uri Muller
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  6. Alexander Yoresh
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  7. Bernard Lerer
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  8. Michael E. Newman
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Weizmann, R., Gur, E., Laor, N. et al. Platelet adenylate cyclase activity in israeli victims of iraqi Scud missile attacks with post-traumatic stress disorder. Psychopharmacology 114 , 509?512 (1994). https://doi.org/10.1007/BF02249343

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  • DOI : https://doi.org/10.1007/BF02249343

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