Lil Wayne has joined the lineup for the Voodoo Experience in New Orleans, to be held Oct. 24-26 at New Orleans' City Park. Wayne, a New Orleans native, will be playing the biggest hometown headlining set of his career at the event.

The rapper recently debuted at No. 1 on The Billboard 200 with his new album, "Tha Carter III," and also logged time atop the Billboard Hot 100 with the single "Lollipop."

As previously reported, the Voodoo Experience will be headlined by R.E.M., Nine Inch Nails and Stone Temple Pilots.

Also on the bill are Death Cab For Cutie, Erykah Badu, Wyclef Jean, Panic At The Disco, Joss Stone, Lupe Fiasco, Dashboard Confessional, DeVotchKa, Sharon Jones and the Dap Kings, Cold War Kids, Ghostland Observatory, Joseph Arthur, Old 97's, Grace Potter and the Nocturnals, the reunited Shudder To Think, the Gutter Twins, Thievery Corporation, Tokyo Police Club and Man Man.

Among the dozens of local and/or non-rock acts set to appear are the Preservation Hall Jazz Band, Irving Mayfield's New Orleans Jazz Orchestra, the New Orleans Bingo! Show, Ozomatli with Chali 2na, the Blind Boys of Alabama, Kermit Ruffins, Dirty Dozen Brass Band, the Iguanas, Bonerama, Marc Broussard and King Britt, the latter staging a tribute to local legend Sister Gertrude Morgan.