???????? ???? ??????? (Malaria),
????
?????? ????????? ?? ??????.
[1]
????? ???????
????????????
??????????? ??????? ?????????. ???????????? ?? ????? ???? ???? ???????????? ?????????? ??????????. ??????? ? ?????? ???????? ??????????????????? ??????? ????? ?????????? "???????? ???? ????????? ????????"??
1907??
?????? ??????
?????????. ??????? ?????????? ????? ????? ??????, ??? ??????, ???????? ??? ???????????? ????????????
1902??
???????? ????
??? ?????? ?????? ?????????. ???
???????? ????
??????? ?????? ???? ????? ?????????
?????????????
?????? ??????? ??????????????? ???????????. ????????? ??? 500 ???????? ????? ??????? ?????? ????? ??? ?????? 2.7 ???????? ???? ??????????????. "????????????" (Plasmodium) ??? ?????????? ?????????? ??????? ?????? ??????.
????????????
??????????
. ???? ???? ?????????
????????????
???? ????????????. ???????????? ???? ???????? ????????? ????? ??????. ????? ?????????????? ?????????? ???????? ????? ???? ?????????? ????????????. ?????? ??????????
- ???????????? ?????????? (falciparum)
- ???????????? ???????? (vivax)
- ???????????? ??????? (malariae)
- ???????????? ????? (ovale)
- ???????????? ????????? (semiovale)
- ???????????? ???????? (knowesli)
???????? ?.????????, ?.?????????? ????????? ??????? ?????????. ?????????? ??????? ???????????? ???????????????.
50000 ????????? ?????? ????? ??????? ?????????? ????? ?????????????.
[2]
???????? ?????? 2700 ?????????
??????
?????????? ???????????? ??????? ?????????? ??????? ???????
[3]
. ??????? ??? ???? "?? ????" ??? ???????? ???? ????? ?????????. "?? ????" ???? ????????? ???? ??? ?????. ??????? ??? ???? ????? ??????? ??????? ????? ??? ? ????????? marsh fever (??????? ?????) ??? ???? ??????????.
1880??
???????
???????? ?????????
???????? ???? ????????? ????????
??????????? ?????????????????? ?????????????? ? ?????? ??????? ???????????. ? ?????? ?????? ??????? ???????? ??????????????? ??????????? ????????????.
[4]
???? ???, ?????? ?????????? ???????? ??????? ??? ??????
1907??
?????? ?????? ?????????. ????????? ?????????? ? ?????? ?????? ???????????? ??? ??????
??????? ?????????
,
???????? ??????
??? ?????? ???? ?????????????? ????????????.
[5]
??? ?????? ?????? ????????????, ???????? ??????, ??? ?????? ??????? ? ?????? ?????? ???? ?????? ????????????? ??????????????.
1898??
??? ???????? ????
??????????
??????? ??????????????? ?????? ???????????. ?????? ???? ???????? ???????
1902??
?????? ?????? ?????????.
[6]
??????? ??? ??????????
[
??????
]
??????? ???????? ????????? ??????? ??? ??????????. ?? ????? ????????? ?????? ????????? ???? ??????? ???????????? ??????? ?????. ??????? ????????????? ??????????? ??????????. ? ?????????? ?????????????? ??????. ??? ????? ?????????? ?????????????, ????? ????? ??? ???????????? ?? ???????, ???? ???? ?????? ?????? ?????????. ??? ?????? ?????? ???????????? ???? ?????? ???????? ???????????. ????? ????? ????? ????????? ???????? ?????. ?????
???????? (anopheles)
??? ???????? ?? ???? ???? ??????? ???????? ?????? ?????????.
??? ??????? ?????? ???? ? ?????? ????????. ??????? ???? ???????? ?????????? ?????? ???????. ??????????????? ????? ????????? ???, ???? ????????????????? ????? ???????? ????? ??? ???? ? ?????? ?????????????.
? ???????????? ???????? ??? ????????????
[
??????
]
?????????? ?????? ????????????????
?????????????? (sporozoites)
??? ??????????. ?????????? ??????????? ?????? ???
??????????
??????, ????? ?? ??????? ?????? ????????????. ??????? ??? ?????????? (merozoite) ???? ???????????. ???????????? ???? ???? ???????????? ???? ?????????? ???????. ????? ???? ??????? ???????????? ?? ????????????. ???? ????? ??? ??????????, ???? ?????????? ? ?????? ?????? ?????? ?????? ???????? ????? ???????????. ??????? ? ?????? ??????????? ????? ???? ??????? ???????????. ????? ???? ????????. ??? ?????? ????? ???? ??????? ???????. ??????
????????? (paroxysm)
??? ??????, ????
????????? ????? ????
.
????? ??? ??????? ??????????????? ?.????????, ?.????? ???????? ?????? ???? ??????. ??? ???????? ?????? ???? ????? ?????? ???????????, ???? ???? ??? ???? ??????? ?????? ???????????. ??????
??????? ??
(dormant phase) " ??? ??????????. ?????? ?????? ???? ???? ?????? ???????????? ?????? ????? ??????? ????????? ??????????????. ? ???????? ??????? ????? ???????? ???????????.
????? ???? ??? ????? ????? ???????????. ??????? ????????? ??????? ?????????? ??????????????.
??????? 2,3 ???? ???????????? ???? ????????? ?????? ?????????? ?? ??????????????. ?????? ?????? ?? ????? ???????? ?????? 5 ???? ?????? ? ?????? ?????????? ???????????.
[7]
?.??????????? ???????? ????? ????????? ???????. ??? ??????? ???????? ?????? ??? ????? ??????? ????? ?????????????. ????????, ???? ??? ???? ????????? ????? ???????? ??????????? ???????????. ???? ??? ??? ?????? ????????? ?????? ????.
??????????? ???? ???? ????
? ?????? ??: ????? ??????? ?????? ?????? ??? ????? ????? ?? ???????? ????.
? ???? ??: ? ???? ???? ???? ??????? ???????????? ????? ????? 40 ??????? ???? ????? ????? ???????.
? ???? ??: ? ???? ???? ???????? ?????????????? ????? ????? ?? ??????? ????? ??????? ????? ???? ????? ????? ???? ???????? ????????, ?????? ????? ????? ?????? ???????.
? ???? ???? ??????? ????? ??????? ?????, 24, 48 ???? 72 ???? ???????? ????????? ???????. ??????? ?????????? ????? ?????? ?????? ??????? ?????? ???? ???? ???? ??????/?????? ??? ?????? ????? ?????? ????????
??????? ??? ?????????? ?????????? ?????
[
??????
]
?????????, ???????????? ???????? ? ??????????? ??????. ?????? ??????? 40% ???? ??????? ????? ?????????? ???????????????. ??????? ????? ????????? ???:
- ???????
- ?????
(???????? ????????, ????????????,
??????????????
)
- ???????????
- ????, ?????? ???????
- ?????? ??????
- ?????? ??????? ?????????
????? ???????? 30,00,00,000 ????? 50,00,00,000 ???? ???? ??????? ????? ???????????. ????? ???????? 10,00,000 ????? 20,00,000 ???? ?????? ??????? ??? ??????????????. ???????????????? 90% ???? ???????????. ?????? ???????? ??????????. ????????? 20% ???? ??????? ??????? ??? 5 ????? ???? ?????????????. ????? ?????? ??????? ?????, ???? ????? ????????? ????? ???????? ???????????? ???????.
? ??????? ???????. ????????? ???????? ???? ???? ???? ?????????? ?????????? ??? ???? ????????????. ???????? ??????? ???????? ????????? ????????????? ??????? ????? ????? ????? 100 ???????. ??????? ???????? ??? ????????? ??????? ?????????. ???? ????????, ? ??? ?????????? ???????? ? ?????? ???? ?????? ????.
?????????? ??? ????????? ???? ???? ??????????????.???? ?????????? (?????? ????? ????? 1800??. ???? ????? ??????, ?????? ??? ????????? ??????????) ??????? ?????? ???????? ????. ????? 5 ????? 7 ????????? ??????? ? ?????? ?????? ?????? ?????? ???????????. 1990-93 ???? ?????? ??????? 500 ????? 600 ??????? ?????? ?????? ????? ???????????? ????? ?????????. 1977-97 ???? ?????? ???? ?????? ?????????? ?????????? ?????? 25% ???? ??????? ?????? ???????? ????? ?????????. 1997 ??? ??????? ???????. ???????????? 60 ??????? ?????? ???? ??????? ?????? ???????? ????? ?????????. ?????? 70 ????? 80% ???? ?????? ?????? ????????? ?????????????.
[8]
1946????? ??????? ????? ?????????
??.??.??
???????? ???????????. 1953?? 7 ????? ???? ?????? ??????? ????? ???????. 8 ????? ???? ?????? ??????? ??????????. ??????? 1958?? "????? ??????? ???????? ??????????" (NMEP - National Malariya Eradication Program) ???????????. ??.??.?? ?????? ??? ????? ????? ?????? ???????? ? ???????? ????????????? ???????? ???????????. ???? 1965?? ? ?????? ??? ?????????????. ??????? ???????? ??.??.??. ?????? ????? ????? ????????????? ?????? ????? ??????? ??????????????. ?????? ??????? ?????? ???????? ?????? ????????? ???????? ?????? ?????????????. ??? ???? ???? ??????????? ????????. ???? ????? 1994?? ???????????? ??????? ?????? ??????????.
[9]
????? ??????? ???????? ????? (National Institute of Malaria Research ), National Academy of Vector Borne Diseases ? ?????????? ??????????? ?????????????????.
[10]
????????? ? ?????? ???????????
[
??????
]
??????? ????? 10 ????? 30 ??????? ????? ??????? (???? ???????????? ????????? ????????????). ? ?????? ???? ???? ??????????? ?????? ???????? ?????????. ?????????? ??????? ????? ???????????????? ?????? ???????? ?????????. ?????? ?????? 10 ????? 30 ??????? ????? ????????. ??????? ??????????? ????? ????????? ????????. ????? ????????????? ?????? ?????????????.
?????
???????????? ????? ????????? ????????????.
???? ????????:
????????? ??????? ????? ?????????? ??????? ???????? ?????????, ??????? ??????? ??????? ??? ???????????????. ????????? ?????????? ???? ??????? ??? ??????????????. ? ????????
????? ????? ??????? (Giemsa blood smear)
??? ??????????. ??????????????? ????? ????????? ????? ???????? ?? ?????? ???? ????? ????, ??????
?????
(Giemsa) ??????? ????????. ??????? ?????????
??????????????
(????????????) ???? ??????? ??????? ????????????. ? ?????? ???? ?????????? ????? ????? ???? ????????????. ? ?????? ?????? ???? ??????????, ???????????. ??????? ????? ?????????????? ??????????, ??????? ??????? ????????? ?????????? ????????? ???????????? ???????????????. ???? ??????? ???????? ???? ???????. ???? ?????? ??????? ???? ?????. ????????? ?????? ???????? ??? ?????????? ? ???? ??????? ???????? ????????.
??????? ???????? ??????
[
??????
]
????????????????? ????? ??????? ? ???? ?????????? ?????? ?????????? ?????? ?????????. ?? ??? ???????????????? ???????? ???? ????? ?????? ??? ???????????. ????? ??????? ??????? ??????? ???????????? ????????? ??????? ???????? ?????????, ???????? ??? ??????????? ????????? ??????? ???????. ??????? ????????????????? ????????? ????????? ????????? ?????? ???????. ??????????????? ???? ??????????? ????? ???? ????????? ???? ?????????. ????????? ????? ?????? ????????? ????? ?????? ?????? ??????. ????????? ????????????? ?? ????????? ??????? ??????? ???? ??????????? ??????. ???????????? ??? ?????? ????????? ??????? ??????? ?????? ??????????. ??????? ????????? ??? ?????????? ???????? ??????? ????????.
???????? ??????? ?????????
??????????????
(chloroquinine) ????????. ???? ???????? ????????? ??? ????????? ??? ?????? ????? ???
????????
(quinine) ????? ???? ????????????????? ?????????????? (quinacrine), ???????????? (chloroquine), ???????????? (primaquine) ????????????. ??????? ??????? ???? ??? ?????? ???? ????? ?????????? ???????????, ?????????? ??? ???? ??????, ??????? ???????.
[11]
[12]
????????? ??? ????????????
[
??????
]
????????? ??????? ???? ???? ???????, ??? ??????? ???????????
????????? ???? ??????? ?????????????:
- ?????? ??????????
- ????? ????????? ?????????? ?????????
- ????????? ??????? ????? ?????? ?????????
?????? ?????????? ????? ???? ???? ??????. ??????? ?????????? ????? ?????? ???????. ????? ?????? ?????????? ????? ?????? ?????????????
???????? ???????? ???????????????
(
??.??.??
) ??? ?????? ?????? ?????? ????????. ??? ???? ?????????? ??????????, ?????? ????????????. ???????? ???? ??????? ????? ????. ???? ??? ??????????? ?????????? ???? ???????????? ?????, ??????? ??????????? ?????? ???? ?????????? ???????????. ???? ? ???? ????????? ???????? ???? ??????? ??????? ?????????????. ?????? ?????? ????? ???? ??.??.???? ?????? ?????????. ???????? ????? ?????????? ?????? ?????????? ??????? ??? ??????????????. ???? ????? ??.??.?? ???? ???? ???? ??????. ???? ?????? ????????? ?????? ???????? ????? ? ???????? ????????? ????????? ???????????????. ? ??????? ????????? ??.??.???? ?????? ????????? ???? ??????????????:
? ?????????? ???? ?????? ??????. ???? ??? ?????????. ??? ??????? ???????? ???? ????????? ??????? ???????????? ??????.
????? ?????????? ?????????
[
??????
]
????????? ???????????? ????? ???????????????????? ???? ????? ?????????????? ???????. ? ?????? ?????????? ???? ??????????. ?????? ????? ????????? ???????? ????????? ??????. ?????? ????????? ???????? ????????. ???????? ???? ????????. ????? ?????? ?????? ???? ??????? ?????? ??????? ??????? ????????? ???????? ??????????. ????????? ?????????? ????????? ?????????, ???? ??? ???????? ????? ???????. ??? ??????? ??????? ???????? ?????????.
????????? ??????? ????? ?????? ?????????
[
??????
]
??????? ????? ?????????? ???????????? ?????????????? (prophylaxis) ??? ?????? ??????? ??????? ????????. ? ???? ?????? ?????????. ????????, ?????? ?????????????? ? ?????? ???? ????????? ????? ???????????????. ??????? ?????????????? ???????????????? ??????? ????? ?????? ????. ? ?????? ???????? ??????? ????? ?????????? ?????????????? ?????? ??????. ?????????????? ?????? ??????? ????? ?????????? ?????? ?????, ?????? ?????? 4 ????? ???? ?????? ???? ????? ????????????.
- ↑
????? ????? ?????? ??????????
- ↑
Joy D; Feng X; Mu J; Furuya T; Chotivanich K; Krettli A; Ho M; Wang A; Suh E; Beerli P; Su X (2003). "Early origin and recent expansion of Plasmodium falciparum".
Science
.
300
(5617): 318?21.
PMID
12690197
.
- ↑
?????? ??? (2002).
"???????? ???????? ?????? ????? ?????? (History of human parasitology)"
.
Clin Microbiol Rev
.
15
(4): 595?612.
PMID
12364371
.
- ↑
"????????? ???????? ????? ??????(Biography of Alphonse Laveran)"
. ?????? ???????? ????
. Retrieved
2007-07-15
.
- ↑
"??????? ????????? (Ettore Marchiafava)"
. Retrieved
2007-07-15
.
- ↑
"???????? ???? ????? ??????"
. ?????? ???????? ????
. Retrieved
2007-07-15
.
- ↑
??????? ??????????! ?????. 23 April 2024
- ↑
"Malaria in India"
. Archived from
the original
on 2007-08-09
. Retrieved
2007-07-21
.
- ↑
"Status of Malaria in India"
(PDF)
.
Shiv Lal, G.S.Soni, P.K.Phukan
. Archived from
the original
(PDF)
on 2006-06-03
. Retrieved
2007-07-21
.
- ↑
"National Institute of Malaria Research"
. Retrieved
2007-07-21
.
- ↑
Prescription drugs for malaria
Retrieved
February 27
,
2007
.
- ↑
"New malaria drug modeled after Traditional Chinese Medicine (TCM)"
. Archived from
the original
on 2007-08-14
. Retrieved
2007-07-22
.
????? ???????, ??????
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??????
]
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