3-MeO-PCMo

3-MeO-PCMo
IUPAC ime
	4-[1-(3-metoksifenil)cikloheksil]morfolin
Pravni status
Pravni status	CA : Plan I ; DE : NpSG ; UK : PSA ;
Identifikatori
CAS broj	138873-80-0
PubChem	CID 132605908
ChemSpider	58191437
UNII	96QW73BA62
Hemijski podaci
Formula	C 17 H 25 N O 2
Molarna masa	275,39?g·mol ?1
	SMILES COC1=CC(C2(N3CCOCC3)CCCCC2)=CC=C1 ; ;
	InChI InChI=1S/C17H25NO2/c1-19-16-7-5-6-15(14-16)17(8-3-2-4-9-17)18-10-12-20-13-11-18/h5-7,14H,2-4,8-13H2,1H3 ; Key:BOGOEDFWPOXWQE-UHFFFAOYSA-N ;

3-MeO-PCMo je disocijativni anestetik koji je po strukturi sli?an fenciklidinu ^[1]^[2] i koji se prodaje onlajn kao dizajnirana droga . ^[3]^[4] Inhibitorni efekat 3-MeO-PCMo na smanjenje gustine klastera drebrina NMDAR stimulacijom glutaminskom kiselinom je ni?i od PCP-a ili 3-MeO-PCP, sa polovinom maksimalne inhibitorne koncentracije (IC ₅₀) od 26,67?μM (3-MeO-PCMo), 2,02?μM (PCP) i 1,51?μM (3-MeO-PCP). ^[5]

Reference

^ Ahmadi A, Khalili M, Hajikhani R, Naserbakht M (април 2011). ?New morpholine analogues of phencyclidine: chemical synthesis and pain perception in rats”. Pharmacology, Biochemistry, and Behavior . 98 (2): 227?33. PMID 21215770 . S2CID 24650035 . doi : 10.1016/j.pbb.2010.12.019 .
^ Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, et?al. (март 2020). ?4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels”. Psychopharmacology . 237 (3): 757?772. PMID 31828394 . S2CID 209169410 . doi : 10.1007/s00213-019-05412-y .
^ Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, et?al. (фебруар 2018). ?Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues”. Drug Testing and Analysis . 10 (2): 272?283. PMID 28513099 . doi : 10.1002/dta.2213 .
^ ?3-MeO-PCMo” . New Synthetic Drugs Database. Архивирано из оригинала 2016-07-03. г . Приступ?ено 2016-02-09 .
^ Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T (2019). ?Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay”. Journal of Pharmacological and Toxicological Methods . 99 : 106583. PMID 31082488 . doi : 10.1016/j.vascn.2019.106583   .

[1] Ahmadi A, Khalili M, Hajikhani R, Naserbakht M (април 2011). ?New morpholine analogues of phencyclidine: chemical synthesis and pain perception in rats”. Pharmacology, Biochemistry, and Behavior . 98 (2): 227?33. PMID 21215770 . S2CID 24650035 . doi : 10.1016/j.pbb.2010.12.019 .

[2] Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, et?al. (март 2020). ?4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels”. Psychopharmacology . 237 (3): 757?772. PMID 31828394 . S2CID 209169410 . doi : 10.1007/s00213-019-05412-y .

[3] Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, et?al. (фебруар 2018). ?Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues”. Drug Testing and Analysis . 10 (2): 272?283. PMID 28513099 . doi : 10.1002/dta.2213 .

[4] ?3-MeO-PCMo” . New Synthetic Drugs Database. Архивирано из оригинала 2016-07-03. г . Приступ?ено 2016-02-09 .

[5] Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T (2019). ?Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay”. Journal of Pharmacological and Toxicological Methods . 99 : 106583. PMID 31082488 . doi : 10.1016/j.vascn.2019.106583   .

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