Merkaptopurin
|
|
|
Klini?ki podaci
|
Robne marke
|
Ismipur, Leukerin, Leupurin, Mercaleukim
|
AHFS/Drugs.com
|
Monografija
|
Identifikatori
|
CAS broj
|
50-44-2
|
ATC kod
|
L01
BB02
|
PubChem
[1]
[2]
|
667490
|
DrugBank
|
DB01033
|
ChemSpider
[3]
|
580869
|
KEGG
[4]
|
C02380
Y
|
ChEBI
|
CHEBI:2208
Y
|
ChEMBL
[5]
|
CHEMBL1425
Y
|
Hemijski podaci
|
Formula
|
C
5
H
4
N
4
S
|
Mol. masa
|
152,177
|
SMILES
|
eMolekuli
&
PubHem
|
InChI
|
InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
Key: GLVAUDGFNGKCSF-UHFFFAOYSA-N
Y
|
|
Fizi?ki podaci
|
Ta?ka topljenja
|
313 °C (595 °F)
|
Farmakokineti?ki
podaci
|
Poluvreme eliminacije
|
45 minuta
|
Farmakoinformacioni podaci
|
Trudno?a
|
?
|
Pravni status
|
|
Na?in primene
|
Oralno
|
Merkaptopurin
je
organsko jedinjenje
, koje sadr?i 5
atoma
ugljenika
i ima
molekulsku masu
od 152,177
Da
.
[6]
[7]
- ↑
Li Q, Cheng T, Wang Y, Bryant SH (2010).
?PubChem as a public resource for drug discovery.”
.
Drug Discov Today
15
(23-24): 1052-7.
DOI
:
10.1016/j.drudis.2010.10.003
.
PMID
20970519
.
edit
- ↑
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). ?Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”.
Annual Reports in Computational Chemistry
4
: 217-241.
DOI
:
10.1016/S1574-1400(08)00012-1
.
- ↑
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010).
?Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”
.
J Cheminform
2
(1): 3.
DOI
:
10.1186/1758-2946-2-3
.
PMID
20331846
.
edit
- ↑
Joanne Wixon, Douglas Kell (2000).
?Website Review: The Kyoto Encyclopedia of Genes and Genomes ? KEGG”
.
Yeast
17
(1): 48?55.
DOI
:
10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H
.
- ↑
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). ?ChEMBL: a large-scale bioactivity database for drug discovery”.
Nucleic Acids Res
40
(Database issue): D1100-7.
DOI
:
10.1093/nar/gkr777
.
PMID
21948594
.
edit
- ↑
Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011).
?DrugBank 3.0: a comprehensive resource for omics research on drugs”
.
Nucleic Acids Res.
39
(Database issue): D1035-41.
DOI
:
10.1093/nar/gkq1126
.
PMC
3013709
.
PMID
21059682
.
- ↑
David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008).
?DrugBank: a knowledgebase for drugs, drug actions and drug targets”
.
Nucleic Acids Res
36
(Database issue): D901-6.
DOI
:
10.1093/nar/gkm958
.
PMC
2238889
.
PMID
18048412
.
- ↑
Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998).
?Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”
.
J. Phys. Chem. A
102
: 3762-3772.
DOI
:
10.1021/jp980230o
.
- ↑
Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001).
?Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”
.
Chem Inf. Comput. Sci.
41
: 1488-1493.
DOI
:
10.1021/ci000392t
.
PMID
11749573
.
- ↑
Ertl P., Rohde B., Selzer P. (2000).
?Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”
.
J. Med. Chem.
43
: 3714-3717.
DOI
:
10.1021/jm000942e
.
PMID
11020286
.