Origem: Wikipedia, a enciclopedia livre.
Avram Hershko
(Karcag, ) e um
bioquimico
israelense
, nascido na
Hungria
.
Juntamente com
Aaron Ciechanover
e
Irwin Rose
, recebeu o
Nobel de Quimica
de 2004, pela descoberta da degradacao das proteinas atraves da
ubiquitina
.
Nascido em Karcag, na Hungria, emigrou em 1950 com a sua familia para
Israel
. Recebeu o seu M.D. em 1965 e o seu Ph.D em 1969 na Faculdade de Medicina Hassadah da
Universidade Hebraica
em
Jerusalem
. E actualmente um distinto professor no "Rappaport Family Institute for Research in Medical Sciences" na Universidade
Technion
(Instituto Israelita de tecnologia), em
Haifa
.
- Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis".
Proc. Natl. Acad. Sci. USA
77, 1783?1786.
- Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206?8214.
- Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619?1623.
- Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
- Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
- Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185?198.
- Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP".
Proc. Natl. Acad. Sci. USA
76, pp. 3107-3110.
- Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis".
Proc. Natl. Acad. Sci. USA
77, pp. 1783-1786.
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1978:
George Davis Snell
,
Jean Dausset
,
Jon van Rood
·
1979:
Roger Sperry
,
Arvid Carlsson
,
Oleh Hornykiewicz
·
1980:
Cesar Milstein
,
Leo Sachs
,
James Learmonth Gowans
·
1981:
Barbara McClintock
,
Stanley Norman Cohen
·
1982:
Jean-Pierre Changeux
,
Solomon Halbert Snyder
,
James Black
·
1984/5:
Donald Frederick Steiner
·
1986:
Osamu Hayaishi
·
1987:
Pedro Cuatrecasas
,
Meir Wilchek
·
1988:
Henri-Gery Hers
,
Elizabeth Neufeld
·
1989:
John Gurdon
,
Edward Lewis
·
1990:
Maclyn McCarty
·
1991:
Seymour Benzer
·
1992:
Judah Folkman
·
1994/5:
Michael Berridge
,
Yasutomi Nishizuka
·
1995/6:
Stanley Prusiner
·
1996/7:
Mary Frances Lyon
·
1998:
Michael Sela
,
Ruth Arnon
·
1999:
Eric Kandel
·
2001:
Avram Hershko
,
Alexander Varshavsky
·
2002/3:
Ralph Lawrence Brinster
,
Mario Capecchi
,
Oliver Smithies
·
2004:
Robert Allan Weinberg
,
Roger Tsien
·
2005:
Anthony Rex Hunter
,
Anthony Pawson
,
Alexander Levitzki
·
2008:
Howard Cedar
,
Aharon Razin
·
2010:
Axel Ullrich
·
2011:
Shinya Yamanaka
,
Rudolf Jaenisch
·
2012:
Ronald Mark Evans
·
2014:
Nahum Sonenberg
,
Gary Ruvkun
,
Victor Ambros
·
2015:
John Kappler
,
Philippa Marrack
,
Jeffrey Ravetch
·
2016:
Carl Ronald Kahn
,
Lewis Cantley
·
2017:
James Patrick Allison
·
2019:
Jeffrey Michael Friedman
·
2020:
Emmanuelle Charpentier
,
Jennifer Doudna
·
2021:
Joan A. Steitz
,
Lynne Elizabeth Maquat
,
Adrian Robert Krainer
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2001:
Knowles
,
Noyori
,
Sharpless
·
2002:
Fenn
,
Tanaka
,
Wuthrich
·
2003:
Agre
,
MacKinnon
·
2004:
Ciechanover
,
Hershko
,
Rose
·
2005:
Chauvin
,
Grubbs
,
Schrock
·
2006:
Kornberg
·
2007:
Ertl
·
2008:
Chalfie
,
Shimomura
,
Tsien
·
2009:
Ramakrishnan
,
Steitz
,
Yonath
·
2010:
Heck
,
Negishi
,
Suzuki
·
2011:
Shechtman
·
2012:
Kobilka
,
Lefkowitz
·
2013:
Karplus
,
Levitt
,
Warshel
·
2014:
Betzig
,
Hell
e
Moerner
·
2015:
Lindahl
,
Modrich
e
Sancar
·
2016:
Sauvage
,
Stoddart
e
Feringa
·
2017:
Dubochet
,
Frank
e
Henderson
·
2018:
Arnold
,
Smith
e
Winter
·
2019:
Goodenough
,
Whittingham
e
Yoshino
·
2020:
Charpentier
e
Doudna
·
2021:
List
e
MacMillan
·
2022:
Bertozzi
,
Meldal
e
Sharpless
·
2023:
Bawendi
,
Brus
e
Ekimov
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