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???????????, ??? ????????? ???????????.
( Stanley B. Prusiner ???? ????? ??????? ??????????????? ???????)
Stanley Prusiner
Prusiner in 2007
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Stanley Ben Prusiner

( 1942-05-28 ) ???? 28, 1942  (82 ??????)
Des Moines, Iowa , United States
?????? American
?????? University of Pennsylvania (BS, MD)
???????????????
????????????(??) Sandy Turk Prusiner [1]
???????? two [1]
?????????? ind .ucsf .edu /ind /aboutus /faculty /prusiners

??? ????????? ???????????????? ????????????????? ????????? ???????? ???????? (????: ???? 28, 1942). ??? ??????????????? ?????????? ????????????? ?????????????????? ??? ?????????????????? ??????????? ?????????? (??????????). ???????????? ?????????? ??????????? ????????? ??????? ??????????????? ????? ?????????? ???????????? ??? ???????? ?????????? ?????????? ?????????. 1994 ? ???????? ???????? ?????????????? ???????? ?????? ??????? 1997 ? ????????? ?????????? ??????? ???? ????????? ????????? ?????????????? ?????? ?????? (?????? ?. ??????, ???? ????????????, ????????? ???????, ????????? ????????) 1970 ????? ????????? ?????????????????? ??????? ??????????? ???????. [2] [3]

??????? ??????, ?????, ?????? [ ????????? ]

???????? ???? ????????? ?????? (??????), ??????????????? ?????? ???????? ?????????? ?????? ???????? ???????. ????????? ???? ????????, ??????????? ?????????????? ??????? ???????????? ??????????. ????? ??????? ???????? ????? ?????????? ???????. ????? ?????????? ????? ???????????????????? ??? ??????? ??????????????? ?????? ??????? ???????????????. ???????? ????????????? ?????? ??????????? ?????????????????? ??????? ???????? ??.?? ??????? ?????????????? ??????????? ??????? ??????? ????. ???????? ??? ??????????????? ?????????? ???????????? ????????????????? ???????????? ?????????????. ???????? ???????? ????? ?????????????????? ??? ????????????? ???? , ????? ?? ?????????????? ???????????? ?.???????? ?????????????? ???????.

???????????? ???????????????????, ???????????? ???????? ?????????????????????? ???????? ??????????????????? ??????. 1974 ? ???????? ?????????? ???? ???????? ??????????? ????????? ??????????? ????????????? ???????. ?????????, ???????????????? ????? ??????????????? ????? ??????????, ??????????? ?????????? ????????? ???????? ???????????????.

1999 ???? ??????????????? ?????????????????? ??? ?????????????????? ??????? ???????? ????????????? ?????????? ????????, ????? ??????? ??????? ????????? ?????????? ???? , ??????????? ????????? ?????????????????. [4]

?????????? ?????????? [ ????????? ]

????? ??????????? ????????????????? ("???????? ??? ????"), ???????????? ???????? ?????? ?????? Creutzfeldt?Jakob disease ??????? ???????? ???????????????? 1997 ? ????????? ???????? ????????? ?????????? ??????? ????? ??????? ????. ? ???????, ??????? ???? ??? 1982-? "?????????????", "????????????" ????? ???????? ?????? ?????????????.

1992 ? ????? ???????? ??? ???????????? 2007 ? ??????? ????????????????? ???????? ????????????????????. ????????? ???????? ??? ?????? ???? ?????? (1993), 1997 ? ???? ???????? (???????????) ?????????? ????? ????, [5] [6] , ????????? ??????????? ???????? (1998), ??????? ???????? ?????? ???? ?????? (2003), ?????????????????? ??? ??????? .

????????? ???????? [ ????????? ]

??????? ????????????????????? ??????????? ??????????? [8] "?????????????" ?????? "?????? ?????????????????" ?????? ?????????????????. 1998 ? ???????? ??????? ???????? ???????????????? ??? ????????? ?????? ?????????????, “??????? ????????-????????? ???????????????? ???????????? ??????????. ??? ???????????? ?????????????? ???????? ?????? ????????? ?????????????????, ????????????? ????????? ???????????????????? ??? ???????? ??????????? ????????. ??????????????, ??? ?????? ?????????????, ????? ??? ??????????? ???????????? ????? ?????????????????? (?????) ?????????????. ??? ????? ??????? ??????????? EAE ?????? ???? ??? ? ??????????? ????????????????????? ?????????. " [9] 2007 ?, ??? ?????????????? ??????????????????? ??? ????????????, ???????? ???????????????????? ??????????? ??????? ????????? (????????) ???????????? ?????? ??????, ????? ?????? ?????????????? ?????????????? ????????????????? ??????????? ????????? ????? ??????? ??? ???? ???????????????? ?????????? ????????????????? ???????? ??????????????????????????????? ??????????? ??????. "????????? ???????????? ??????????? ?????? ??????????? ??????????????????????, ??????????? ????? ??????? ????????? ?????? ??????, ?????????? ?????-????????? ???????????? ??????????????? ?????? ?????? ?????????????????????, ? 25-???? ???????? ???????? ?????????????. ". [10]

????? ???????? ???????????? ?????? ???????????? ?????? ???? ????? ????????, ?????????? ???????????? ??????????????? ?????????????????????? ??????, "????? ??????????????????? ???????? ????? ??????? [?????????????? ????? ???????] ??? ???????????????????????? ???? ??????????????." [11] 1986 ?? ???????? ???????? ???????? ?????????????????? ????????? ?????????? ??????? ??????????? ??????????? ?????????????????? ?????????, ?????? ???????????? ???????? ??????? ???????????? ???????? ?????????? ??????? ?????????????????? ?????????? ?????????? ????????? ?????? ?????????????? ????????? ???????????? ?????? ?????????????? ????????? ?????????? ??????????????????. [12] ?????????????? ???????? ?????????? ???????????? 1985 ? ?????????? ?????????? ??? ????? ????????. ?????? ?????????????? ????????????? ??????????????????? ??????????. ? ??? ????????? ?????????????? ?????????? ???????????????????? ??????????? ?????? ??????????. [13] 1993 ? ????? ??????????????? ???????? ???????? ???? ???????????. ? ???????, ????????? ??????? ??????????? ????????????? ???????????? ???????? ????????????????? ???????? ??? ??????????? ????, ??????? ????????? ???????, ????????? ??????????? ????????????, ?????????????? ???????? ?????????? ???????????????.

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Scholia has an author profile for ????????? ???????? ???????? .
  1. ↑ 1.0 1.1 1.2 ????????? ???????? ???????? on Nobelprize.org വിക്കിഡാറ്റയിൽ തിരുത്തുക
  2. ↑ Prusiner S. B. (1982). "Novel proteinaceous infectious particles cause scrapie". Science . 216 (4542): 136?144. Bibcode : 1982Sci...216..136P . doi : 10.1126/science.6801762 . PMID   6801762 .
  3. ↑ Prusiner S. B. (1991). "Molecular biology of prion diseases". Science . 252 (5012): 1515?1522. Bibcode : 1991Sci...252.1515P . doi : 10.1126/science.1675487 . PMID   1675487 .
  4. ↑ "UCSF - Prusiner Laboratory - Stanley B. Prusiner, M.D." 28 August 2008. Archived from the original on 28 August 2008 . Retrieved 9 May 2018 .
  5. ↑ "Fellows of the Royal Society" . London: Royal Society . Archived from the original on 2015-03-16.
  6. ↑ "Fellowship of the Royal Society 1660-2015" . Royal Society. Archived from the original on 2015-10-15.
  7. ↑ [https: //achievement.org/our-history/golden-plate-awards/#science-exploration https: //achievement.org/our-history/golden-plate-awards/#science-exploration]. {{ cite web }} : Check |url= value ( help ) ; Missing or empty |title= ( help ) ; Unknown parameter |???????= ignored ( help ) ; Unknown parameter |????????.= ignored ( help ) ; Unknown parameter |??????????= ignored ( help )
  8. ↑ Koehnlein, Claus (2020). Virus Mania . Lahnstein: emu-Verlag. p. 220. ISBN   978-3-7519-4253-9 .
  9. ↑ Scholz, Roland (2005). Phantom BSE-Gefahr, Irrwege von Wissinschaft und Politik Im BSE-Skandal . Berenkamp. p. 153.
  10. ↑ Manuelidis, Laura (February 2007). "Cells infected with scrapie and Creutzfeldt?Jakob disease agents produce intracellular 25-nm virus-like particles" . Proceedings of the National Academy of Sciences . 104 (6): 1965?1970. Bibcode : 2007PNAS..104.1965M . doi : 10.1073/pnas.0610999104 . PMC   1794316 . PMID   17267596 .
  11. ↑ Prusiner, Stanley (February 2005). "Fruehtests auf Rinderwahn". Spektrum der Wissenschaft : 62?69.
  12. ↑ "Jetzt wird das Pestizid als BSE-Ausloeser diskutiert". Arzte Zeitung . April 15, 1998.
  13. ↑ Whatley, Stephen (May 11, 1998). "Phostmet-induces up-regulation of surface levels of the cellular prion protein". NeuroReport : 1391?1395.

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