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????????? ( ????????? , β,3,4-???????????- N -???????????????? ), ?????? , ?????????????????? ? ????????? ^[1]^[2]? ??????????? ?????????? ? ????????????? ?????????? ????? ???????????? ???????? ?????? ? ???????? ?? ????????????? ??? ?????? ????????? ? ?????????????????? ????????? ?????? , ?????, ??????????? ???????? ????????? ??????????????, ???????? ?? ????? ????????? ?????? ????????? ??????????????? ^[3]? ???? ????????????? ????????, ?????????? ????????? ? ??? ????????? ??? ???????????? ???? ???????????? ?????????? ?

????????????? ?????????? ?????? ????????? ???????? ???????????? ?????????? ? (????? 80 %-?), ??? ?????????????? ??????????? ????????????? ? ????????????? ???????????????? ?????????? ?? ????????????? ????? ????? ????????? ?? ????????????????? ????????? ? ???????????? ? ?????????? ?????????? ?????? ? ? ????????????? ? ?????? ??? ??????????? ?????? ? ????? ????? ?????? ^[4]?

?????????? ?????????????????? ????? ?????????? ??? ?????????? ? ????????? ?????? ????????????? ?????????? ??????????????, ?????? ??? ≪???? ??? ?????≫ ??????? ??????????? ??????? ^[5]^[6]?

?????? [ ???????? | ???????? ???? ]

?????????? ? ??????? ??????????? ??????? ? ??????????? , ???? ?? ????????????? ??????????? ? ???????? (????????????) ??????? ??????????????? ??????? ???????? ? ??????? ????????? ??????? - ????????????????? (????) - ??????? - ???????????? - ?????????? ????????????? ????????? ? ???????? ????????? ?????????????? ????????? ?????????? ?? ????????????? ??? ?? ????????? ??????-????????? ???????? ? ?????? ????????? ??????? ?????????????? ?????????? ?? ??? ???????? , ????? ???????????? ????? ???? ??? ??????? ???? ????? ???????? ^[7]?

????? ??? ????? ?????????? ??????????? ?????????????? 2 ???? ?? ??? ?????????? ? ?????????????????? ? ???????-?-????????????????? , ??? ????????? ??????????? ????????? ?? ????? ?

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????????????? ??????????? ?????? ????? ?????? ? ??? ???????? ???????? ?????????? 1985 ????????? ??? ???????????, ???? ???????????, ??????????? ?? ??? ??? ?????????????? ^[8]? ???????? ??????? ?????? ????????? ? ?? ???????? ????? ??????? ?????? ????? ????????????? ?????????? 1900 ???????? ^[9]^[10]? 1901 ???????? ????????? ????????? ? ????? ?????????????? ???????????? ??????? ???????? ?????????? ?????? ????? 1904 ???????? ????????? ? ??????? ?????? ? ????? ???????? ?????? ?????????????????? ????? ?????? ^[11]?

???????????? [ ???????? | ???????? ???? ]

?????????? ????????????? ??????????? ? α- ? β- ???????????????? ??????? ?? ??? ????????? ?????????? ? ???????? ???????????? ?????? ???????????????? ??? ^[12]?

?????????? ????????? ? ?????? ????????? ? ????? ?????????? ???????? , ??? ???? ? ????????? ????????? ???????????, ?????????? ?? ?????????? ????????? ? ???? ?????? ????????????? ? ??????????? ? ??????????? ???????????????? ????????????? ?????????? ????? ? ??? ????????????? ????? ??????? ?????? ???????? ??? ? ????? ????

???? ???????? ??? ?????????? ??????? ? ?????? ????????????? β2-???????????????? ??????? ??????? ?????????? ?????????? ? ????????? ? ????????? ????????, ??????? ????????-???????? ????? ???? ???????? ??????????, ??? α1-???????????????? ?????? ??????? ?????? ? ??? ??????????? ???????? ?????? ? ???????? ?????? ? ??? ??????????

?????????? ?????? ? ????????????????? ????? ????? ????????????? ???? ??? ??????????? ? ???????????????? ? ????????? ??????????, ?????????? ????????? ???????, ??????????? ????????? ?????? ????? ??? ^[13]? ?????????? ??????????? ? ??????? ???????? ? ?????????? ????? ???????? ??? ????????????? ????????????? ? ???????? ?????????? β3-?????????????????

?????????? ??????????? ? ???????? ??????????????????, ???? ?? ??????? ?????????? ??????? ? ????????? ???????? ??? ??????? ? ??????? ????????????? ??????? ?????????? ?????????? ?????? ??????????? ??????? ????????? ???????? ?? ????????? ??????? ???????? ??? ?? ????????? ? ?????? ?????? ? ????????? ?????????????????? ???????? ????????? ????????????? ????????????? ????? ?????????? ????? ????????????? ?????? ????????????? ?????????? ? ????????????? ??????? ? ???????? ???????? ???????, ???? ?? ?????????? ? ???????? ??????? ??????? ????????? ??????????

?????????? ??????????? ? ??????????? ????????? ????????? ?????? ??????????? ????????????????, ?????????? ? ??????????????? ? ?????????????, ??????? ??????????????????? ?????????? ? ????????????, ??????? ? ??????????????? ??????? ? ??????????? ????????????? - ???????? - ???????????? ?????????, ??? ??????????? ????? ??? ???????? ????????? ??????????? ? ?????????? ????????????? ????????????? ??? ? ??????????? ????????? ???????????????????? ?????? ?????????

?????????? ???? ??????? ??????????? ? ?????????????? ????????????, ???? ?? ?????????? ? ????????? , ?????????? , ????????? ??????????????, ?????? ??? ?????????? ????????????? ??????????????? ??? ???????? ????????? ?????????? ????? ??? ??????????? ? ????????????? ?????? ?? ????????????? ? ?????????? ????? ?????????? , ???? ???????? ? ??? ?????????? ???????? ??????????

????????????? ????? ?????? ??? [ ???????? | ???????? ???? ]

?????????? ???????????? ????????? ?? ????? ?????? ???????? ???? ????.

???????? ????????????? ? β1-????????????????? ???????, ??? ??????? ??????? ????????? ???????? ???????? ?????????? ? ????? ???????? ??????? ?
??????????? ????????????? ? ??????? ????? ? ?????? ????????? ????????????????? ???????, ??? ??????????? ? ??????? ?????? ???????? ?????? ?????? ? ?????????? ???????? (????????) ???????? ??? ??????? ???? ?????????? ????????????? ??????? ? ? ??????????????? ????????? ? ???????????? ????? ?????? ???????????? ???? ???, ?????????? ????????? ?????? ? ??????? ?????? ???????? ??? ? ??????????? ????
????????? ?????????? ??????????? ????????????? ?????????? ? ?????????? ??????? ??? ????? ????????????? ? α1- ? α2-???????????????? ????????
????????, ?????? β2-???????????????? ???????? ???????????? ? ????? ?????? ?????????

?????????????????? [ ???????? | ???????? ???? ]

↑ Lieberman M, Marks A, Peet A (2013). Marks' Basic Medical Biochemistry: A Clinical Approach (4th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ?? 175. ISBN 9781608315727 .
↑ ≪(-)-adrenaline≫ . Guide to Pharmacology . IUPS/BPS . ??????? ? 2015 ?? ???????? 21-?? .
↑ epinephrine and norepinephrine. (2009). Encyclopædia Britannica. Encyclopædia Britannica 2009 Deluxe Edition. Chicago: Encyclopædia Britannica.
↑ Berecek Kh, B. M.; Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Am J Physiol 242 (4): H593?H601. PMID 6278965
↑ Editorial (1982). "Stress, hypertension, and the heart: the adrenaline trilogy". Lancet 2: 1440?1441.
↑ Pearce., JMS (2009). "Links between nerves and glands: the story of adrenaline". Advances in Clinical Neuroscience & Rehabilitation 9: 22?28.
↑ Kirshner, Norman; Goodall, McC. (1957). "The Formation of Adrenaline From Noradrenaline". Biochimica et Biophysica Acta 24 (3): 658?659. doi:10.1016/0006-3002(57)90271-8 . PMID 13436503
↑ "Polish Thread in the History of Circulatory Physiology" . Retrieved 24 April 2011.
↑ Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145?59. doi:10.1007/BF02281628 . PMID 10454061
↑ Yamashima T (2003). "Jokichi Takamine (1854?1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95?102. PMID 12717538
↑ Takamine J (1901). "The isolation of the active principle of the suprarenal gland" . The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix?xxx.
↑ Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 4. ISBN 1-59541-101-1
↑ Sabyasachi Sircar (2007). Medical Physiology. Thieme Publishing Group. p. 536. ISBN 3-13-144061-9

??????? ???????? [ ???????? | ???????? ???? ]

??????????? ???? ???????, ????? ?????????? ?? ≪?????????≫ ?????????

??? ??????? ??? ??? ????? ??????? ??????? ????????? ??? ???????? ????????? ??????? ? ???????? ??????? ?????????????? ???????? 3.0 (Creative Commons BY-SA 3.0) ???? ????????????? ????????? ???????? ????????? ?????????????? ( ?? 1, ?? 91 )?

[Chan2013-1] Lieberman M, Marks A, Peet A (2013). Marks' Basic Medical Biochemistry: A Clinical Approach (4th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ?? 175. ISBN 9781608315727 .

[2] ≪(-)-adrenaline≫ . Guide to Pharmacology . IUPS/BPS . ??????? ? 2015 ?? ???????? 21-?? .

[3] rine and norepinephrine. (2009). Encyclopædia Britannica. Encyclopædia Britannica 2009 Deluxe Edition. Chicago: Encyclopædia Britannica.

[4] Berecek Kh, B. M.; Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Am J Physiol 242 (4): H593?H601. PMID 6278965

[5] Editorial (1982). "Stress, hypertension, and the heart: the adrenaline trilogy". Lancet 2: 1440?1441.

[6] Pearce., JMS (2009). "Links between nerves and glands: the story of adrenaline". Advances in Clinical Neuroscience & Rehabilitation 9: 22?28.

[7] Kirshner, Norman; Goodall, McC. (1957). "The Formation of Adrenaline From Noradrenaline". Biochimica et Biophysica Acta 24 (3): 658?659. doi:10.1016/0006-3002(57)90271-8 . PMID 13436503

[8] "Polish Thread in the History of Circulatory Physiology" . Retrieved 24 April 2011.

[9] Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145?59. doi:10.1007/BF02281628 . PMID 10454061

[10] Yamashima T (2003). "Jokichi Takamine (1854?1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95?102. PMID 12717538

[11] Takamine J (1901). "The isolation of the active principle of the suprarenal gland" . The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix?xxx.

[12] Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 4. ISBN 1-59541-101-1

[13] Sabyasachi Sircar (2007). Medical Physiology. Thieme Publishing Group. p. 536. ISBN 3-13-144061-9

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