???????

???????
?? IUPAC
	(1 S ,4 S )-4-(3,4-dichlorophenyl)- N -methyl-1,2,3,4-tetrahydronaphthalen-1-amine
???? ??????? ? ?????
	??????, ?????, ???????, ??????? ???
?????? ??????
???? ????	C 17 H 17 N Cl 2
??? ??????	306.229 ??? ????
?????? ?????????????
?????? ????????	44%
????????	????, (N- ???????? ????? ?? ??? ?????? CYP2B6 )
??? ????? ????	23-26 ????
?????	??? ??????
??????
???? ????	????? ????
???????? ????? ??????	???????? ????? C (????????) , ???????? ????? C
???? ???	??? ???
?????
??? ACT	N06AB06
???? CAS	79617-96-2
PubChem	68617
ChemSpider	61881

??????? (? ?????? : Sertraline ; ???? ??????? : ?????? [Zoloft], ?????? [Lustral], ????? [Serenada] ???????? ??? [Sertraline Teva]) ??? ????? ????? ?????? ?????? ????? ?????? ?????? ?? ???????? SSRI ), ??????? ??????? ???? ??????? ???? 1991 ?? ??? ???? ????? (Pfizer). ??????? ????? ????? ? ???? ? ?????? ????? ??? ??????? ??? ?? ? ????? ???????-??????? , ????? ?????? , ????? ???? ?????? ?????? ???? ?????? ??? ??????? ??????. ???? 2011 , ?????? ????? ????? ???? ????? ??????? ?????? ? ????? ????? ??????? ??????????? (37 ?????? ??????). ^[3]

??????? ???? ???? ????? ?????? ????? ???? ?? ??????? ??????? ????? ? ?????? ?????? . ???? ????? ??? ?????? ???????? ????? ???? ? ?????????? (?????) ?????? ????? ??? ????? ?? ??????. ^[4] ????? ?????? ?????? ????? ??????? ???? ?????? ????? ????? ??????? ?????? ?????? ????? ?????. ^[5] ??????? ???? ????? ?????? ?????? ??????? ??????? ????? ????? ?????????-???????? (CBT); ?? ???, ?????? ??? ?????? ?????? ?-SSRI ?????? ?-CBT ???? ?? ??????? ?????? ?????. ^[6]^[7] ?? ?? ???, ????? ?????? ??????? ??????? ????? ??????? ?????? ???? ????? ?????? ???????. ??????? ????? ????? ?? ?????? ?? ???? ?????? ? ????? ???? ???????? . ^[8]^[9]

??? ?? [ ????? ??? ???? | ????? ]

??????? ???????? [ ????? ??? ???? | ????? ]

???? ?????? ????? ??????? ? ??????????

???? " ??????? ", ???? " ?????????? "
??????? ???????? ?? ?????? ??????
???? ?? ??????? - Sertraline , ????? ?????? ???????????, ???? "????? ??????? ???? ???".
?????, ?????? ????? ???? ???? ???? ???????? ????

????? ?????? [ ????? ??? ???? | ????? ]

^ ??????? ????? ???????, ??? ???????, ???? ???????
^ Obach RS, Cox LM, Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metab. Dispos . 33 (2): 262?70. doi : 10.1124/dmd.104.002428 . PMID 15547048 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )
^ John M. Grohol (2012). "Top 25 Psychiatric Medication Prescriptions for 2011" . Psych Central. ????? ?- ????? ?-2013-07-02 . ???? ?- 9 ?????? 2013 . {{ cite web }}: ( ???? )
^ Flament MF, Lane RM, Zhu R, Ying Z (1999). "Predictors of an acute antidepressant response to fluoxetine and sertraline". Int Clin Psychopharmacol . 14 (5): 259?75. doi : 10.1097/00004850-199914050-00001 . PMID 10529069 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )
^ Hirschfeld RM (2000). "Sertraline in the treatment of anxiety disorders". Depress Anxiety . 11 (4): 139?57. doi : 10.1002/1520-6394(2000)11:4<139::AID-DA1>3.0.CO;2-C . PMID 10945134 .
^ Pediatric OCD Treatment Study (POTS) Team (2004). "Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial". JAMA . 292 (16): 1969?76. doi : 10.1001/jama.292.16.1969 . PMID 15507582 .
^ Sousa MB, Isolan LR, Oliveira RR, Manfro GG, Cordioli AV (2006). "A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder". The Journal of Clinical Psychiatry . 67 (7): 1133?9. doi : 10.4088/JCP.v67n0717 . PMID 16889458 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )
^ Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN ( ???? 2008 ). "Efficacy and tolerability of second-generation antidepressants in social anxiety disorder" . Int Clin Psychopharmacol . 23 (3): 170?9. doi : 10.1097/YIC.0b013e3282f4224a . PMC 2657552 . PMID 18408531 . {{ cite journal }}: ( ???? ) ?????? - ?????: multiple names: authors list ( link )
^ Watts BV, Schnurr PP, Mayo L, Young-Xu Y, Weeks WB, Friedman MJ ( ????? 2013 ). "Meta-analysis of the efficacy of treatments for posttraumatic stress disorder". J Clin Psychiatry . 74 (6): e541?50. doi : 10.4088/JCP.12r08225 . PMID 23842024 . {{ cite journal }}: ( ???? ) ?????? - ?????: multiple names: authors list ( link )

?????: ????? ?????????? ???? ?????? ???? ? ???? ????? ????? ????? .

[hebrewRTL-מאגרתרופות-1] ??????? ????? ???????, ??? ???????, ???? ???????

[pmid15547048-2] Obach RS, Cox LM, Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metab. Dispos . 33 (2): 262?70. doi : 10.1124/dmd.104.002428 . PMID 15547048 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )

[3] John M. Grohol (2012). "Top 25 Psychiatric Medication Prescriptions for 2011" . Psych Central. ????? ?- ????? ?-2013-07-02 . ???? ?- 9 ?????? 2013 . {{ cite web }}: ( ???? )

[pmid10529069-4] Flament MF, Lane RM, Zhu R, Ying Z (1999). "Predictors of an acute antidepressant response to fluoxetine and sertraline". Int Clin Psychopharmacol . 14 (5): 259?75. doi : 10.1097/00004850-199914050-00001 . PMID 10529069 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )

[pmid10945134-5] Hirschfeld RM (2000). "Sertraline in the treatment of anxiety disorders". Depress Anxiety . 11 (4): 139?57. doi : 10.1002/1520-6394(2000)11:4<139::AID-DA1>3.0.CO;2-C . PMID 10945134 .

[pmid15507582-6] Pediatric OCD Treatment Study (POTS) Team (2004). "Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial". JAMA . 292 (16): 1969?76. doi : 10.1001/jama.292.16.1969 . PMID 15507582 .

[pmid16889458-7] Sousa MB, Isolan LR, Oliveira RR, Manfro GG, Cordioli AV (2006). "A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder". The Journal of Clinical Psychiatry . 67 (7): 1133?9. doi : 10.4088/JCP.v67n0717 . PMID 16889458 . {{ cite journal }}: ?????? - ?????: multiple names: authors list ( link )

[8] Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN ( ???? 2008 ). "Efficacy and tolerability of second-generation antidepressants in social anxiety disorder" . Int Clin Psychopharmacol . 23 (3): 170?9. doi : 10.1097/YIC.0b013e3282f4224a . PMC 2657552 . PMID 18408531 . {{ cite journal }}: ( ???? ) ?????? - ?????: multiple names: authors list ( link )

[9] Watts BV, Schnurr PP, Mayo L, Young-Xu Y, Weeks WB, Friedman MJ ( ????? 2013 ). "Meta-analysis of the efficacy of treatments for posttraumatic stress disorder". J Clin Psychiatry . 74 (6): e541?50. doi : 10.4088/JCP.12r08225 . PMID 23842024 . {{ cite journal }}: ( ???? ) ?????? - ?????: multiple names: authors list ( link )

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