YTHDC1

YTHDC1
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2YUD , 4R3H , 4R3I
?????????????
??????? ????	YTHDC1 , YT521, YT521-B, YTH domain containing 1
????????? ??????	OMIM: 617283 MGI: 2443713 HomoloGene: 15796 GeneCards: YTHDC1
?????? ?? (???)
????????	???????? ? (???)
?????	86,984,518 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? RNA binding ; ? N6-methyladenosine-containing RNA binding ;
??????? ?????	? ???? ????? ; ? nuclear speck ; ? ????? ????? ; ? ??????????? ;
?????? ?????	? mRNA processing ; ? mRNA splice site selection ; ? ?????? ??????? ; ? regulation of mRNA splicing, via spliceosome ; ? mRNA export from nucleus ; ? dosage compensation by inactivation of X chromosome ; ? posttranscriptional regulation of gene expression ;
	?????: ????? / ????????
?????????????
	91746
	231386
	ENSG00000275272 ; ENSG00000083896
	ENSMUSG00000035851
	Q96MU7
	E9Q5K9
	NM_133370? XM_005265708? NM_001330698 NM_001031732? NM_133370? XM_005265708? NM_001330698
	XM_006534863? XM_006534865? XM_006534867? XR_389269? XM_017320843? NM_001347375? NM_001347376? NM_001359907? NM_001359908? NR_153372? XM_030254395? XR_003955632? XR_004942503 NM_177680? XM_006534863? XM_006534865? XM_006534867? XR_389269? XM_017320843? NM_001347375? NM_001347376? NM_001359907? NM_001359908? NR_153372? XM_030254395? XR_003955632? XR_004942503
	NP_001317627? NP_588611? XP_005265764? XP_005265765? XP_016864321? XP_016864322 NP_001026902? NP_001317627? NP_588611? XP_005265764? XP_005265765? XP_016864321? XP_016864322
	NP_001334305? NP_808348? XP_006534926? XP_006534928? XP_006534930? XP_017176332? NP_001346836? NP_001346837? XP_030110255 NP_001334304? NP_001334305? NP_808348? XP_006534926? XP_006534928? XP_006534930? XP_017176332? NP_001346836? NP_001346837? XP_030110255
	?????????
??????/?????? ?????	??????/?????? ???

??????? ????? ? ???? ????? YTH ( ??????? : YTH domain-containing protein 1 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ YTHDC1 ≫ ???????? ??????. ^[?]^[?]^[?]

??? ??????? ?? ???????-??????? ????? CSK ^[?] ? ????? ^[?] ????? ???????-??????? ????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000035851 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci . 27 (10): 495?7. doi : 10.1016/S0968-0004(02)02189-8 . PMID 12368078 .
↑ Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)" . Mol Biol Cell . 10 (11): 3909?26. doi : 10.1091/mbc.10.11.3909 . PMC 25688 . PMID 10564280 .
↑ "Entrez Gene: YTHDC1 YTH domain containing 1" .
↑ Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet . 13 (15): 1535?49. doi : 10.1093/hmg/ddh167 . PMID 15175272 .
↑ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem . 270 (11): 2459?66. doi : 10.1046/j.1432-1033.2003.03617.x . PMID 12755701 .

?????????????? ?????????. ≪ YTHDC1 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

???? ??????? ????? [ ?????? ]

Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Res. Mol. Brain Res . 53 (1?2): 33?40. doi : 10.1016/S0169-328X(97)00262-3 . PMID 9473574 .
Nayler O, Hartmann AM, Stamm S (2000). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment" . J. Cell Biol . 150 (5): 949?62. doi : 10.1083/jcb.150.5.949 . PMC 2175241 . PMID 10973987 .
Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, Stamm S (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites". J. Biol. Chem . 276 (12): 8665?73. doi : 10.1074/jbc.M006851200 . PMID 11118435 .
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res . 8 (6): 319?27. doi : 10.1093/dnares/8.6.319 . PMID 11853319 .
Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem . 270 (11): 2459?66. doi : 10.1046/j.1432-1033.2003.03617.x . PMID 12755701 .
Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet . 13 (15): 1535?49. doi : 10.1093/hmg/ddh167 . PMID 15175272 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130?5. doi : 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S (2005). "p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1". Mol. Cell. Neurosci . 27 (1): 8?21. doi : 10.1016/j.mcn.2004.04.011 . PMID 15345239 .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55?65. doi : 10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Nousiainen M, Sillje HH, Sauer G, Nigg EA, Korner R (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391?6. doi : 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220 .
Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285?92. doi : 10.1038/nbt1240 . PMID 16964243 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635?48. doi : 10.1016/j.cell.2006.09.026 . PMID 17081983 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000035851 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid12368078-4] Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci . 27 (10): 495?7. doi : 10.1016/S0968-0004(02)02189-8 . PMID 12368078 .

[pmid10564280-5] Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)" . Mol Biol Cell . 10 (11): 3909?26. doi : 10.1091/mbc.10.11.3909 . PMC 25688 . PMID 10564280 .

[entrez-6] "Entrez Gene: YTHDC1 YTH domain containing 1" .

[pmid15175272-7] Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet . 13 (15): 1535?49. doi : 10.1093/hmg/ddh167 . PMID 15175272 .

[pmid12755701-8] Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem . 270 (11): 2459?66. doi : 10.1046/j.1432-1033.2003.03617.x . PMID 12755701 .

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