XPC

XPC
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2A4J , 2GGM , 2OBH , 2RVB
?????????????
??????? ????	XPC , RAD4, XP3, XPCC, p125, xeroderma pigmentosum, complementation group C, XPC complex subunit, DNA damage recognition and repair factor
????????? ??????	OMIM: 613208 MGI: 103557 HomoloGene: 3401 GeneCards: XPC
?????? ?? (???)
????????	???????? ? (???)
?????	91,492,870 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? DNA binding ; ? heteroduplex DNA loop binding ; ? bubble DNA binding ; ? single-stranded DNA binding ; ? damaged DNA binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? GO:0032403 protein-containing complex binding ;
??????? ?????	? ????????? ; ? ????? ????? ; ? ??????????? ; ? XPC complex ; ? ???? ; ? nucleotide-excision repair factor 2 complex ; ? ???? ????? ; ? ????????? ; ? intracellular membrane-bounded organelle ; ? nucleotide-excision repair complex ;
?????? ?????	? nucleotide-excision repair ; ? regulation of mitotic cell cycle phase transition ; ? nucleotide-excision repair, DNA damage recognition ; ? mitotic intra-S DNA damage checkpoint signaling ; ? cellular response to DNA damage stimulus ; ? global genome nucleotide-excision repair ; ? response to auditory stimulus ; ? ??????? ??????? ???????? ; ? response to UV-B ; ? UV-damage excision repair ; ? GO:0100026 ??????? ???????? ; ? nucleotide-excision repair, preincision complex assembly ; ? nucleotide-excision repair, DNA duplex unwinding ;
	?????: ????? / ????????
?????????????
	7508
	22591
	ENSG00000154767
	ENSMUSG00000030094
	Q01831
	P51612
	NM_001145769? NM_004628? NR_027299? XR_001740256 XM_011534093? NM_001145769? NM_004628? NR_027299? XR_001740256
	NM_009531
	NP_001341655? NP_001341656? NP_001341658? NP_001341659 NP_004619? NP_001341655? NP_001341656? NP_001341658? NP_001341659
	NP_033557
	?????????
??????/?????? ?????	??????/?????? ???

???????? ??????????? ???? ???? ?? ( ??????? : Xeroderma pigmentosum, complementation group C ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ XPC ≫ ???????? ?????? ^[?] ?? ?? ??? ??????? ? ???? ???????. ^[?]

??? ??????? ?? ??????? ??????? ? ????????? ????? ?????? ???????? ?? ?????? ????? ??????? ????????? ??? ????? ???? ????. ^[?]

????? ?????? [ ?????? ]

??? ?? ?? ≪ XPC ≫ ??? ???? ?????? ???? ???????? ?????????? ?? ???? ?? ?????? ^[?] ?? ?? ?? ??? ?? ???? ?????? ?? ????? ????? ???? ??? ?????? (??? ?? ???? ?? ???? ????) ???? ????? ???? ??????. ??? ?? ?????? ???????? ?? ???? ???? ????? ????? ??? ? ????? ????? ??? ????.

??????? ???? ???? ?? ≪ *XPC* ≫ ?? ???? ????? ??. ????? ????? ?? ??? ??????? ???? ???? ??? ???
?????	???????	????.
????? ?????	???	^[?]
????? ????????? ???????? ?? ??????? ???? ??????	???	^[?]
????? ????? ???????? ?? ???? ?????	???	^[?]
????? ????? ???????? ?? ???? ????	???	^[?]
????? ??? ?? ??? ???? ??????? (NSCLC)	???	^[?]
????? ??? ?? ??? ???? ???????? ????? ?	???	^[?]
????? ??? ?? ??? ???? ???????? ????? ? ? ?	???	^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030094 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ ^??? ^??? ^??? "Entrez Gene: XPC xeroderma pigmentosum, complementation group C" .
↑ "OMIM Entry - # 278720 - XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C; XPC" . Retrieved 12 December 2014 .
↑ ^??? ^??? ^??? ^??? Yang J, Xu Z, Li J, Zhang R, Zhang G, Ji H, Song B, Chen Z (2010). "XPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome". J. Urol . 184 (1): 336?43. doi : 10.1016/j.juro.2010.03.044 . PMID 20488473 .
↑ ^??? ^??? ^??? Yeh KT, Wu YH, Lee MC, Wang L, Li CT, Chen CY, Lee H (2012). "XPC mRNA level may predict relapse in never-smokers with non-small cell lung cancers". Ann. Surg. Oncol . 19 (3): 734?42. doi : 10.1245/s10434-011-1992-9 . PMID 21861227 . S2CID 19154489 .

???? ??????? ????? [ ?????? ]

Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy". Hum. Mutat . 14 (1): 9?22. doi : 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 . PMID 10447254 . S2CID 24148589 .
El-Deiry WS (2003). "Transactivation of repair genes by BRCA1" . Cancer Biol. Ther . 1 (5): 490?1. doi : 10.4161/cbt.1.5.162 . PMID 12496474 .
Sugasawa K (2007). "UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair". J. Mol. Histol . 37 (5?7): 189?202. doi : 10.1007/s10735-006-9044-7 . PMID 16858626 . S2CID 817898 .
Legerski R, Peterson C (1993). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C" . Nature . 360 (6404): 610. doi : 10.1038/360610b0 . PMID 1461286 .
Legerski R, Peterson C (1992). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C". Nature . 359 (6390): 70?3. Bibcode : 1992Natur.359...70L . doi : 10.1038/359070a0 . PMID 1522891 . S2CID 34276965 .
Legerski RJ, Liu P, Li L, Peterson CA, Zhao Y, Leach RJ, Naylor SL, Siciliano MJ (1994). "Assignment of xeroderma pigmentosum group C (XPC) gene to chromosome 3p25". Genomics . 21 (1): 266?9. doi : 10.1006/geno.1994.1256 . PMID 8088800 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1?2): 171?4. doi : 10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, Takio K, Tanaka K, van der Spek PJ, Bootsma D (1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23" . EMBO J . 13 (8): 1831?43. doi : 10.1002/j.1460-2075.1994.tb06452.x . PMC 395023 . PMID 8168482 .
Li L, Bales ES, Peterson CA, Legerski RJ (1994). "Characterization of molecular defects in xeroderma pigmentosum group C". Nat. Genet . 5 (4): 413?7. doi : 10.1038/ng1293-413 . PMID 8298653 . S2CID 24923699 .
Li L, Peterson C, Legerski R (1996). "Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene" . Nucleic Acids Res . 24 (6): 1026?8. doi : 10.1093/nar/24.6.1026 . PMC 145764 . PMID 8604333 .
van der Spek PJ, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, Hanaoka F, Bootsma D, Hoeijmakers JH (1996). "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes" . Nucleic Acids Res . 24 (13): 2551?9. doi : 10.1093/nar/24.13.2551 . PMC 145966 . PMID 8692695 .
Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts with both HHR23B and HHR23A in vivo". Mutat. Res . 383 (3): 197?203. doi : 10.1016/s0921-8777(97)00002-5 . PMID 9164480 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1?2): 149?56. doi : 10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Zeng L, Quilliet X, Chevallier-Lagente O, Eveno E, Sarasin A, Mezzina M (1998). "Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C" . Gene Ther . 4 (10): 1077?84. doi : 10.1038/sj.gt.3300495 . PMID 9415314 .
Khan SG, Levy HL, Legerski R, Quackenbush E, Reardon JT, Emmert S, Sancar A, Li L, Schneider TD, Cleaver JE, Kraemer KH (1998). "Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia" . J. Invest. Dermatol . 111 (5): 791?6. doi : 10.1046/j.1523-1747.1998.00391.x . PMID 9804340 .
Yokoi M, Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka F (2000). "The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA" . J. Biol. Chem . 275 (13): 9870?5. doi : 10.1074/jbc.275.13.9870 . PMID 10734143 .
Batty D, Rapic'-Otrin V, Levine AS, Wood RD (2000). "Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites". J. Mol. Biol . 300 (2): 275?90. doi : 10.1006/jmbi.2000.3857 . PMID 10873465 .
Araujo SJ, Nigg EA, Wood RD (2001). "Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome" . Mol. Cell. Biol . 21 (7): 2281?91. doi : 10.1128/MCB.21.7.2281-2291.2001 . PMC 86862 . PMID 11259578 .
Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, Ohkuma Y, Hanaoka F (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair" . J. Biol. Chem . 276 (22): 18665?72. doi : 10.1074/jbc.M100855200 . PMID 11279143 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030094 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[entrez-4] ??? ^??? ^??? "Entrez Gene: XPC xeroderma pigmentosum, complementation group C" .

[5] "OMIM Entry - # 278720 - XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C; XPC" . Retrieved 12 December 2014 .

[Yang-6] ??? ^??? ^??? ^??? Yang J, Xu Z, Li J, Zhang R, Zhang G, Ji H, Song B, Chen Z (2010). "XPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome". J. Urol . 184 (1): 336?43. doi : 10.1016/j.juro.2010.03.044 . PMID 20488473 .

[Yeh-7] ??? ^??? ^??? Yeh KT, Wu YH, Lee MC, Wang L, Li CT, Chen CY, Lee H (2012). "XPC mRNA level may predict relapse in never-smokers with non-small cell lung cancers". Ann. Surg. Oncol . 19 (3): 734?42. doi : 10.1245/s10434-011-1992-9 . PMID 21861227 . S2CID 19154489 .

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