TBCE

TBCE
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	4ICU , 4ICV
?????????????
??????? ????	TBCE , HRD, KCS, KCS1, pac2, tubulin folding cofactor E, PEAMO
????????? ??????	OMIM: 604934 MGI: 1917680 HomoloGene: 37744 GeneCards: TBCE
?????? ?? (???)
????????	???????? ?? (???)
?????	14,214,223 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? chaperone binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? alpha-tubulin binding ;
??????? ?????	? ????????? ; ? ??????? ; ? ????? ????? ;
?????? ?????	? post-chaperonin tubulin folding pathway ; ? ?????? ??????? ; ? GO:0043148 mitotic spindle organization ; ? microtubule cytoskeleton organization ; ? tubulin complex assembly ;
	?????: ????? / ????????
?????????????
	6905
	70430
	ENSG00000116957
	ENSMUSG00000039233
	Q15813
	Q8CIV8
	NM_001079515? NM_001287801? NM_001287802 NM_003193? NM_001079515? NM_001287801? NM_001287802
	XM_006516773? XM_006516775? NR_130788? XR_873135? XR_001780813? XM_030247407? XR_003950480? XR_003950481? XR_003950482? XM_036158163? XR_004938070? XR_004938071? XR_004938072 NM_178337? XM_006516773? XM_006516775? NR_130788? XR_873135? XR_001780813? XM_030247407? XR_003950480? XR_003950481? XR_003950482? XM_036158163? XR_004938070? XR_004938071? XR_004938072
	NP_001274730? NP_001274731? NP_003184 NP_001072983? NP_001274730? NP_001274731? NP_003184
	XP_006516836? XP_006516838? XP_030103267? XP_036014056 NP_848027? XP_006516836? XP_006516838? XP_030103267? XP_036014056
	?????????
??????/?????? ?????	??????/?????? ???

TBCE ?? ?????? ????? ????? E ???????? ??????? ( ??????? : Tubulin-specific chaperone E ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ TBCE ≫ ??????? ??????. ^[?]^[?] ???????? E ??? ?? ???? ???????? ??? ?? ???? ?????? ? ?????? ???? ??????? ???-??????? ????? ???.

??? ?? ??? ?? TBCE ???? ?? ????? ????? ????-???? ???????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000039233 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell . 86 (2): 287?96. doi : 10.1016/S0092-8674(00)80100-2 . PMID 8706133 .
↑ "Entrez Gene: TBCE tubulin folding cofactor E" .

?????????????? ?????????. ≪ TBCE ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

????? ??????? [ ?????? ]

Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin" . J. Cell Biol . 132 (1?2): 1?4. doi : 10.1083/jcb.132.1.1 . PMC 2120700 . PMID 8567715 .
Parvari R, Diaz GA, Hershkovitz E (2007). "Parathyroid development and the role of tubulin chaperone E". Horm. Res . 67 (1): 12?21. doi : 10.1159/000095944 . PMID 17008776 .
Tian G, Lewis SA, Feierbach B, et al. (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors" . J. Cell Biol . 138 (4): 821?32. doi : 10.1083/jcb.138.4.821 . PMC 2138046 . PMID 9265649 .
Parvari R, Hershkovitz E, Kanis A, et al. (1998). "Homozygosity and linkage-disequilibrium mapping of the syndrome of congenital hypoparathyroidism, growth and mental retardation, and dysmorphism to a 1-cM interval on chromosome 1q42-43" . Am. J. Hum. Genet . 63 (1): 163?9. doi : 10.1086/301915 . PMC 1377236 . PMID 9634513 .
Diaz GA, Khan KT, Gelb BD (1999). "The autosomal recessive Kenny-Caffey syndrome locus maps to chromosome 1q42-q43". Genomics . 54 (1): 13?8. doi : 10.1006/geno.1998.5530 . PMID 9806825 .
Roobol A, Sahyoun ZP, Carden MJ (1999). "Selected subunits of the cytosolic chaperonin associate with microtubules assembled in vitro". J. Biol. Chem . 274 (4): 2408?15. doi : 10.1074/jbc.274.4.2408 . PMID 9891010 .
Parvari R, Hershkovitz E, Grossman N, et al. (2002). "Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome". Nat. Genet . 32 (3): 448?52. doi : 10.1038/ng1012 . PMID 12389028 .
Martin N, Jaubert J, Gounon P, et al. (2002). "A missense mutation in Tbce causes progressive motor neuronopathy in mice". Nat. Genet . 32 (3): 443?7. doi : 10.1038/ng1016 . PMID 12389029 .
Bommel H, Xie G, Rossoll W, et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease" . J. Cell Biol . 159 (4): 563?9. doi : 10.1083/jcb.200208001 . PMC 2173089 . PMID 12446740 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566?9. doi : 10.1038/nbt810 . PMID 12665801 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173?8. doi : 10.1038/nature04209 . PMID 16189514 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55?65. doi : 10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature . 441 (7091): 315?21. doi : 10.1038/nature04727 . PMID 16710414 .
Kortazar D, Fanarraga ML, Carranza G, et al. (2007). "Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation". Exp. Cell Res . 313 (3): 425?36. doi : 10.1016/j.yexcr.2006.09.002 . PMID 17184771 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000039233 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid8706133-4] Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell . 86 (2): 287?96. doi : 10.1016/S0092-8674(00)80100-2 . PMID 8706133 .

[entrez-5] "Entrez Gene: TBCE tubulin folding cofactor E" .

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