TAS2R16

TAS2R16
?????????????
??????? ????	TAS2R16 , T2R16, taste 2 receptor member 16, BGLPT
????????? ??????	OMIM: 604867 MGI: 2681247 HomoloGene: 9660 GeneCards: TAS2R16
?????? ?? (???)
????????	???????? ? (???)
?????	23,970,059 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? G protein-coupled receptor activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? signal transducer activity ; ? bitter taste receptor activity ;
??????? ?????	? trans-Golgi network ; ? ????? ????? ; ? ???? ?????????? ; ? external side of plasma membrane ; ? membrane ; ? integral component of membrane ;
?????? ?????	? detection of chemical stimulus involved in sensory perception of bitter taste ; ? GO:0072468 ???????? ???? ; ? response to stimulus ; ? sensory perception of taste ; ? G protein-coupled receptor signaling pathway ;
	?????: ????? / ????????
?????????????
	50833
	387347
	ENSG00000128519
	ENSMUSG00000043865
	Q9NYV7
	P59529
	NM_016945
	NM_207022
	NP_058641
	NP_996905
	?????????
??????/?????? ?????	??????/?????? ???

??????? ????? ??? ?? ??? ?? ( ??????? : Taste receptor type 2 member 16 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ TAS2R16 ≫ ???????? ??????. ^[?]^[?]

??? ?? ? ???????? ?? ?? ????? ????? ? ??????? ????? ???? ??? ??? ?????.

????? ?? ??? ?? ?? ?????? ?????? ??????? ?? ???? (???? ????) ?? ?????? ???. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000043865 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet . 32 (3): 397?401. doi : 10.1038/ng1014 . PMID 12379855 .
↑ Drewnowski A (2001). "The science and complexity of bitter taste" . Nutr Rev . 59 (6): 163?9. doi : 10.1111/j.1753-4887.2001.tb07007.x . PMID 11444592 .
↑ Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence" . Am. J. Hum. Genet . 78 (1): 103?11. doi : 10.1086/499253 . PMC 1380207 . PMID 16385453 .

?????????????? ?????????. ≪ TAS2R16 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ????? ????.

????? ??????? [ ?????? ]

Kinnamon SC (2000). "A plethora of taste receptors". Neuron . 25 (3): 507?10. doi : 10.1016/S0896-6273(00)81054-5 . PMID 10774719 .
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem . 277 (1): 1?4. doi : 10.1074/jbc.R100054200 . PMID 11696554 .
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366?71. doi : 10.1016/S0959-4388(02)00345-8 . PMID 12139982 .
Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell . 100 (6): 693?702. doi : 10.1016/S0092-8674(00)80705-9 . PMID 10761934 .
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell . 100 (6): 703?11. doi : 10.1016/S0092-8674(00)80706-0 . PMID 10761935 .
Firestein S (2000). "The good taste of genomics". Nature . 404 (6778): 552?3. doi : 10.1038/35007167 . PMID 10766221 .
Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601?4. doi : 10.1038/35007072 . PMID 10766242 .
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat. Genet . 32 (3): 397?401. doi : 10.1038/ng1014 . PMID 12379855 .
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell . 112 (3): 293?301. doi : 10.1016/S0092-8674(03)00071-0 . PMID 12581520 .
Fischer A, Gilad Y, Man O, Paabo S (2005). "Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432?6. doi : 10.1093/molbev/msi027 . PMID 15496549 .
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates" . Genetics . 170 (1): 313?26. doi : 10.1534/genetics.104.037523 . PMC 1449719 . PMID 15744053 .
Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ (2005). "The receptors and coding logic for bitter taste". Nature . 434 (7030): 225?9. doi : 10.1038/nature03352 . PMID 15759003 .
Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence" . Am. J. Hum. Genet . 78 (1): 103?11. doi : 10.1086/499253 . PMC 1380207 . PMID 16385453 .
Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem . 281 (29): 20650?9. doi : 10.1074/jbc.M513637200 . PMID 16720576 .

????? ?? ????? [ ?????? ]

?? TAS2R16 ?? ?????? ????????? GeneCard
TAS2R16 protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000043865 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet . 32 (3): 397?401. doi : 10.1038/ng1014 . PMID 12379855 .

[5] Drewnowski A (2001). "The science and complexity of bitter taste" . Nutr Rev . 59 (6): 163?9. doi : 10.1111/j.1753-4887.2001.tb07007.x . PMID 11444592 .

[pmid16385453-6] Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence" . Am. J. Hum. Genet . 78 (1): 103?11. doi : 10.1086/499253 . PMC 1380207 . PMID 16385453 .

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