TAS2R14

TAS2R14
?????????????
??????? ????	TAS2R14 , T2R14, TRB1, taste 2 receptor member 14
????????? ??????	OMIM: 604790 MGI: 2681298 HomoloGene: 87013 GeneCards: TAS2R14
?????? ?? (???)
????????	???????? ? (???)
?????	133,032,779 bp
?????????? ??
?????? ??????	? G protein-coupled receptor activity ; ? signal transducer activity ; ? taste receptor activity ; ? bitter taste receptor activity ;
??????? ?????	? ????? ????? ; ? membrane ; ? integral component of membrane ;
?????? ?????	? detection of chemical stimulus involved in sensory perception of bitter taste ; ? GO:0072468 ???????? ???? ; ? response to stimulus ; ? sensory perception of taste ; ? G protein-coupled receptor signaling pathway ;
	?????: ????? / ????????
?????????????
	50840
	387616
	ENSG00000212127 ; ENSG00000261984 ; ENSG00000276541
	ENSMUSG00000071147
	Q9NYV8
	Q7TQA4
	NM_023922
	NM_021562
	NP_076411
	NP_067537
	?????????
??????/?????? ?????	??????/?????? ???

??????? ????? ??? ?? ??? ?? ( ??????? : Taste receptor type 2 member 14 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ TAS2R14 ≫ ???????? ??????. ^[?]^[?]^[?]

??? ?? ? ???????? ?? ??? ????? ?? ????? ? ????? ??? ???? ??? ?????.

??? ??????? ????? ????? ?? ????? ?? ?????????? ??? ????? ????? ??? ???? ?????? ? ???????? ???? ????? ????? ????? ????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000071147 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell . 100 (6): 693?702. doi : 10.1016/S0092-8674(00)80705-9 . PMID 10761934 .
↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601?4. doi : 10.1038/35007072 . PMID 10766242 .
↑ "Entrez Gene: TAS2R14 taste receptor, type 2, member 14" .
↑ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction" . Nat. Med . 16 (11): 1299?304. doi : 10.1038/nm.2237 . PMC 3066567 . PMID 20972434 .

?????????????? ?????????. ≪ TAS2R14 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ????? ????.

????? ??????? [ ?????? ]

Kinnamon SC (2000). "A plethora of taste receptors". Neuron . 25 (3): 507?10. doi : 10.1016/S0896-6273(00)81054-5 . PMID 10774719 .
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem . 277 (1): 1?4. doi : 10.1074/jbc.R100054200 . PMID 11696554 .
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366?71. doi : 10.1016/S0959-4388(02)00345-8 . PMID 12139982 .
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell . 100 (6): 703?11. doi : 10.1016/S0092-8674(00)80706-0 . PMID 10761935 .
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell . 112 (3): 293?301. doi : 10.1016/S0092-8674(03)00071-0 . PMID 12581520 .
Fischer A, Gilad Y, Man O, Paabo S (2005). "Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432?6. doi : 10.1093/molbev/msi027 . PMID 15496549 .
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates" . Genetics . 170 (1): 313?26. doi : 10.1534/genetics.104.037523 . PMC 1449719 . PMID 15744053 .
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry" . J. Proteome Res . 4 (6): 2070?80. doi : 10.1021/pr0502065 . PMC 1850943 . PMID 16335952 .
Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem . 281 (29): 20650?9. doi : 10.1074/jbc.M513637200 . PMID 16720576 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000071147 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10761934-4] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell . 100 (6): 693?702. doi : 10.1016/S0092-8674(00)80705-9 . PMID 10761934 .

[pmid10766242-5] Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601?4. doi : 10.1038/35007072 . PMID 10766242 .

[entrez-6] "Entrez Gene: TAS2R14 taste receptor, type 2, member 14" .

[pmid20972434-7] Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction" . Nat. Med . 16 (11): 1299?304. doi : 10.1038/nm.2237 . PMC 3066567 . PMID 20972434 .

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