STAT4

STAT4
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??????? ????	STAT4 , SLEB11, signal transducer and activator of transcription 4
????????? ??????	OMIM: 600558 MGI: 103062 HomoloGene: 20679 GeneCards: STAT4
?????? ?? (???)
????????	???????? ? (???)
?????	52,146,348 bp
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? GO:0001131? GO:0001151? GO:0001130? GO:0001204 DNA-binding transcription factor activity ; ? DNA binding ; ? identical protein binding ; ? GO:0001200? GO:0001133? GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ; ? GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; ? GO:0001077? GO:0001212? GO:0001213? GO:0001211? GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ;
??????? ?????	? ????????? ; ? ???? ????? ; ? ??????????? ; ? ??????? ;
?????? ?????	? transcription, DNA-templated ; ? GO:0009373 regulation of transcription, DNA-templated ; ? receptor signaling pathway via JAK-STAT ; ? GO:0072468 ???????? ???? ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? interleukin-12-mediated signaling pathway ; ? cytokine-mediated signaling pathway ; ? interleukin-21-mediated signaling pathway ; ? interleukin-23-mediated signaling pathway ; ? interleukin-35-mediated signaling pathway ; ? defense response ; ? regulation of cell population proliferation ; ? response to peptide hormone ;
	?????: ????? / ????????
?????????????
	6775
	20849
	ENSG00000138378
	ENSMUSG00000062939
	Q14765
	P42228
	NM_003151? XM_006712719? XM_011511705? XM_017004784 NM_001243835? NM_003151? XM_006712719? XM_011511705? XM_017004784
	XM_006495815? XM_006495816? NM_001308266 NM_011487? XM_006495815? XM_006495816? NM_001308266
	NP_003142? XP_006712782? XP_011510007? XP_016860273 NP_001230764? NP_003142? XP_006712782? XP_011510007? XP_016860273
	NP_035617? XP_006495878? XP_006495879 NP_001295195? NP_035617? XP_006495878? XP_006495879
	?????????
??????/?????? ?????	??????/?????? ???

STAT4 ?? ????? ???? ???????? ??????????? ??????????? ???? ? ??????????? ??????? 4 ( ??????? : Signal transducer and activator of transcription 4) ???? ??????? ????? ?? ??????? ???????? STAT ??? ^[?] ?? ???? ????? ? ????? ??????? ?? ????????? ??? ?? ?? ???????? ??????? ?? ??? ???? ???? ???? ? ?? ???? ?? ?????????? ?? ??? ????? ????????? ???? ??????. ^[?] ????? STAT4 ?? ???????? ???????? ????? ? ???? ????? ??? ^[?] ?? ??????? ?? ?? ??? ??????? ????? ?? ???? ????? ????? ???? ??????? ??? ????? ?? ?? ????? PHA ????? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000062939 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Ihle, J. N.; Silvennoinen, O.; Copeland, N. G.; Jenkins, N. A.; Gilbert, D. J.; Kreider, B. L.; Thierfelder, W. E.; Quelle, F. W.; Yamamoto, K. (1994-07-01). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation" . Molecular and Cellular Biology (?? ???????). 14 (7): 4342?4349. doi : 10.1128/MCB.14.7.4342 . ISSN 0270-7306 . PMID 8007943 . Archived from the original on 30 January 2019 . Retrieved 29 January 2019 .
↑ Kaplan, Mark H. (2005-04-01). "STAT4" . Immunologic Research (?? ???????). 31 (3): 231?241. doi : 10.1385/IR:31:3:231 . ISSN 1559-0755 .
↑ Yamamoto, K.; Quelle, F. W.; Thierfelder, W. E.; Kreider, B. L.; Gilbert, D. J.; Jenkins, N. A.; Copeland, N. G.; Silvennoinen, O.; Ihle, J. N. (1994-7). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation" . Molecular and Cellular Biology . 14 (7): 4342?4349. ISSN 0270-7306 . PMID 8007943 . {{ cite journal }}: Check date values in: |date= ( help )
↑ Bacon, C M; Petricoin, E F; Ortaldo, J R; Rees, R C; Larner, A C; Johnston, J A; O'Shea, J J (1995-08-01). "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes" . Proceedings of the National Academy of Sciences of the United States of America . 92 (16): 7307?7311. ISSN 0027-8424 . PMID 7638186 .

??? ?? ?????? ??? ????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000062939 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] Ihle, J. N.; Silvennoinen, O.; Copeland, N. G.; Jenkins, N. A.; Gilbert, D. J.; Kreider, B. L.; Thierfelder, W. E.; Quelle, F. W.; Yamamoto, K. (1994-07-01). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation" . Molecular and Cellular Biology (?? ???????). 14 (7): 4342?4349. doi : 10.1128/MCB.14.7.4342 . ISSN 0270-7306 . PMID 8007943 . Archived from the original on 30 January 2019 . Retrieved 29 January 2019 .

[5] Kaplan, Mark H. (2005-04-01). "STAT4" . Immunologic Research (?? ???????). 31 (3): 231?241. doi : 10.1385/IR:31:3:231 . ISSN 1559-0755 .

[6] Yamamoto, K.; Quelle, F. W.; Thierfelder, W. E.; Kreider, B. L.; Gilbert, D. J.; Jenkins, N. A.; Copeland, N. G.; Silvennoinen, O.; Ihle, J. N. (1994-7). "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation" . Molecular and Cellular Biology . 14 (7): 4342?4349. ISSN 0270-7306 . PMID 8007943 . {{ cite journal }}: Check date values in: |date= ( help )

[7] Bacon, C M; Petricoin, E F; Ortaldo, J R; Rees, R C; Larner, A C; Johnston, J A; O'Shea, J J (1995-08-01). "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes" . Proceedings of the National Academy of Sciences of the United States of America . 92 (16): 7307?7311. ISSN 0027-8424 . PMID 7638186 .

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