SPRED1

SPRED1
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	3SYX
?????????????
??????? ????	SPRED1 , NFLS, PPP1R147, hSpred1, spred-1, sprouty related EVH1 domain containing 1, LGSS
????????? ??????	OMIM: 609291 MGI: 2150016 HomoloGene: 24919 GeneCards: SPRED1
?????? ?? (???)
????????	???????? ? (???)
?????	117,012,760 bp
?????????? ??
?????? ??????	? protein serine/threonine kinase inhibitor activity ; ? phosphatase binding ; ? stem cell factor receptor binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? protein kinase binding ;
??????? ?????	? membrane ; ? ????? ????? ; ? ???? ????? ; ? ??????? ; ? ???? ????? ; ? GO:0016023 cytoplasmic vesicle ;
?????? ?????	? negative regulation of phosphatase activity ; ? negative regulation of peptidyl-threonine phosphorylation ; ? regulation of protein deacetylation ; ? MAPK cascade ; ? multicellular organism development ; ? fibroblast growth factor receptor signaling pathway ; ? regulation of signal transduction ; ? positive regulation of DNA damage response, signal transduction by p53 class mediator ; ? vasculogenesis involved in coronary vascular morphogenesis ; ? negative regulation of cell migration involved in sprouting angiogenesis ; ? negative regulation of MAPK cascade ; ? negative regulation of protein kinase activity ; ? negative regulation of angiogenesis ; ? regulation of MAPK cascade ; ? negative regulation of ERK1 and ERK2 cascade ;
	?????: ????? / ????????
?????????????
	161742
	114715
	ENSG00000166068
	ENSMUSG00000027351
	Q7Z699
	Q924S8
	XM_005254202? XM_047432199? XM_047432200? XM_047432201 NM_152594? XM_005254202? XM_047432199? XM_047432200? XM_047432201
	NM_033524 NM_001277256? NM_033524
	XP_005254259? XP_011519591 NP_689807? XP_005254259? XP_011519591
	NP_277059 NP_001264185? NP_277059
	?????????
??????/?????? ?????	??????/?????? ???

SPRED1 ?? ???? ????? ≪??????? ?????? ? ???? ??????? EVH1? ????? ?? ????????≫ ( ??????? : Sprouty-related, EVH1 domain-containing protein 1 ) ???? ?? ??????? ??? ?? ?? ????? ???? ?? ≪SPRED1≫ ??? ??????. ??? ?? ?? ??? ????? ???? ???????? ?? ???? ??? ? ????? ? ????? ???????? ???. ^[?]

??? ?????? ????? ????? ?? ???????? ???????? ???????? ??? ?? ?? ???? ?? ??? ?????? ??? ???? ??????? ????? ??????? ??????.

?????? ?? ??? ?? ??? ?? ???????? ???? ?? ???? ≪????? ?????????????????? ??? ?≫ (NFLS)? ^[?] ????? ????? ^[?]^[?] ? ????? ??? ?????? ^[?] ???.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000027351 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ ^??? ^??? "Entrez Gene: sprouty-related" .
↑ Messiaen L, Yao S, Brems H, Callens T, Sathienkijkanchai A, Denayer E, Spencer E, Arn P, Babovic-Vuksanovic D, Bay C, Bobele G, Cohen BH, Escobar L, Eunpu D, Grebe T, Greenstein R, Hachen R, Irons M, Kronn D, Lemire E, Leppig K, Lim C, McDonald M, Narayanan V, Pearn A, Pedersen R, Powell B, Shapiro LR, Skidmore D, Tegay D, Thiese H, Zackai EH, Vijzelaar R, Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E (November 2009). "Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome". JAMA . 302 (19): 2111?8. doi : 10.1001/jama.2009.1663 . PMID 19920235 . {{ cite journal }}: Unknown parameter |laysource= ignored ( help ) ; Unknown parameter |laysummary= ignored ( help )
↑ "Legius Syndrome (SPRED1) Sequencing & (NF1) Sequencing Exon 22 (Exon 17)" (PDF) . ARUP Laboratories . 2010. Archived from the original (pdf) on 30 May 2012 . Retrieved 2011-06-07 .
↑ Pasmant E, Ballerini P, Lapillonne H, Perot C, Vidaud D, Leverger G, Landman-Parker J (July 2009). "SPRED1 disorder and predisposition to leukemia in children". Blood . 114 (5): 1131. doi : 10.1182/blood-2009-04-218503 . PMID 19643996 .

?????????????? ?????????. ≪ SPRED1 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000027351 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[entrez-4] ??? ^??? "Entrez Gene: sprouty-related" .

[pmid19920235-5] Messiaen L, Yao S, Brems H, Callens T, Sathienkijkanchai A, Denayer E, Spencer E, Arn P, Babovic-Vuksanovic D, Bay C, Bobele G, Cohen BH, Escobar L, Eunpu D, Grebe T, Greenstein R, Hachen R, Irons M, Kronn D, Lemire E, Leppig K, Lim C, McDonald M, Narayanan V, Pearn A, Pedersen R, Powell B, Shapiro LR, Skidmore D, Tegay D, Thiese H, Zackai EH, Vijzelaar R, Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E (November 2009). "Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome". JAMA . 302 (19): 2111?8. doi : 10.1001/jama.2009.1663 . PMID 19920235 . {{ cite journal }}: Unknown parameter |laysource= ignored ( help ) ; Unknown parameter |laysummary= ignored ( help )

[urlwww.aruplab.com-6] "Legius Syndrome (SPRED1) Sequencing & (NF1) Sequencing Exon 22 (Exon 17)" (PDF) . ARUP Laboratories . 2010. Archived from the original (pdf) on 30 May 2012 . Retrieved 2011-06-07 .

[Pasmant_2009-7] Pasmant E, Ballerini P, Lapillonne H, Perot C, Vidaud D, Leverger G, Landman-Parker J (July 2009). "SPRED1 disorder and predisposition to leukemia in children". Blood . 114 (5): 1131. doi : 10.1182/blood-2009-04-218503 . PMID 19643996 .

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