SLC6A20

SLC6A20
?????????????
??????? ????	SLC6A20 , SIT1, XT3, Xtrp3, solute carrier family 6 member 20, IMINO
????????? ??????	OMIM: 605616 MGI: 2143217 HomoloGene: 10625 GeneCards: SLC6A20
?????? ?? (???)
????????	???????? ? (???)
?????	123,507,950 bp
?????????? ??
?????? ??????	? neurotransmitter:sodium symporter activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? symporter activity ; ? amino acid transmembrane transporter activity ; ? L-proline transmembrane transporter activity ;
??????? ?????	? integral component of membrane ; ? ????? ????? ; ? integral component of plasma membrane ; ? apical plasma membrane ; ? membrane ; ? brush border membrane ;
?????? ?????	? neurotransmitter transport ; ? amino acid transport ; ? glycine transport ; ? proline transport ; ? amino acid transmembrane transport ; ? transmembrane transport ; ? proline transmembrane transport ;
	?????: ????? / ????????
?????????????
	54716
	102680
	ENSG00000163817
	ENSMUSG00000036814
	Q9NP91
	Q8VDB9
	NM_020208? NM_022405? XM_011533847? NM_001385683 XM_011533848? NM_020208? NM_022405? XM_011533847? NM_001385683
	NM_139142
	NP_071800? XP_011532149? XP_011532150 NP_064593? NP_071800? XP_011532149? XP_011532150
	NP_631881
	?????????
??????/?????? ?????	??????/?????? ???

???????? ? ?????????? ?????? ??? ?? ( ??????? : Solute carrier family 6, member 20 ) ?? ?? ??? ??????? SLC6A20 ?????? ??????? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ SLC6A20 ≫ ?? ??? ???????? ? ???????? ??????. ^[?]^[?]

????? ?????? [ ?????? ]

??? ?? ?? ≪ SLC6A20 ≫ ?? ???? ?????? ?????? ???????????????? ?? ?????? ???. ^[?]

????????? ???? ???? ???????? ?? SLC6A20? ??? ?? ? ??? ??? ?? ?????? ???? ??????? ????? ?? ??????? ????? ?? ????? ?? ?? ?????? ???????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000036814 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Nash SR, Giros B, Kingsmore SF, Kim KM, el-Mestikawy S, Dong Q, et al. (1998). "Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms". Receptors & Channels . 6 (2): 113?28. PMID 9932288 .
↑ Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, et al. (April 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics . 73 (1): 10?9. doi : 10.1006/geno.2000.6498 . PMID 11352561 .
↑ Broer S, Bailey CG, Kowalczuk S, Ng C, Vanslambrouck JM, Rodgers H, et al. (December 2008). "Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters" . The Journal of Clinical Investigation . 118 (12): 3881?92. doi : 10.1172/JCI36625 . PMC 2579706 . PMID 19033659 .
↑ Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, et al. (June 2020). "Genomewide Association Study of Severe Covid-19 with Respiratory Failure" . The New England Journal of Medicine . 383 (16): 1522?1534. doi : 10.1056/NEJMoa2020283 . PMC 7315890 . PMID 32558485 .

?????????????? ?????????. ≪ SLC6A20 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Nash SR, Giros B, Kingsmore SF, Kim KM, el-Mestikawy S, Dong Q, et al. (1998). "Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms". Receptors & Channels . 6 (2): 113?28. PMID 9932288 .
Broer A, Balkrishna S, Kottra G, Davis S, Oakley A, Broer S (August 2009). "Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20)". Molecular Membrane Biology . 26 (5): 333?46. doi : 10.1080/09687680903150027 . PMID 19657969 . S2CID 21001936 .
Broer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia" . Physiological Reviews . 88 (1): 249?86. doi : 10.1152/physrev.00018.2006 . PMID 18195088 .
Takanaga H, Mackenzie B, Suzuki Y, Hediger MA (March 2005). "Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino" . The Journal of Biological Chemistry . 280 (10): 8974?84. doi : 10.1074/jbc.M413027200 . PMID 15632147 .
Kanei-Ishii C, Nomura T, Tanikawa J, Ichikawa-Iwata E, Ishii S (October 2004). "Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation" . The Journal of Biological Chemistry . 279 (43): 44582?9. doi : 10.1074/jbc.M407831200 . PMID 15308626 .
Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, et al. (April 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics . 73 (1): 10?9. doi : 10.1006/geno.2000.6498 . PMID 11352561 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000036814 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid9932288-4] Nash SR, Giros B, Kingsmore SF, Kim KM, el-Mestikawy S, Dong Q, et al. (1998). "Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms". Receptors & Channels . 6 (2): 113?28. PMID 9932288 .

[pmid11352561-5] Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, et al. (April 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics . 73 (1): 10?9. doi : 10.1006/geno.2000.6498 . PMID 11352561 .

[pmid19033659-6] Broer S, Bailey CG, Kowalczuk S, Ng C, Vanslambrouck JM, Rodgers H, et al. (December 2008). "Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters" . The Journal of Clinical Investigation . 118 (12): 3881?92. doi : 10.1172/JCI36625 . PMC 2579706 . PMID 19033659 .

[7] Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, et al. (June 2020). "Genomewide Association Study of Severe Covid-19 with Respiratory Failure" . The New England Journal of Medicine . 383 (16): 1522?1534. doi : 10.1056/NEJMoa2020283 . PMC 7315890 . PMID 32558485 .

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