SHB

SHB
?????????????
??????? ????	SHB , bA3J10.2, SH2 domain containing adaptor protein B
????????? ??????	OMIM: 600314 MGI: 98294 HomoloGene: 74458 GeneCards: SHB
?????? ?? (???)
????????	???????? ? (???)
?????	45,532,470 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? phosphotyrosine residue binding ; ? GO:0001948? GO:0016582 ????? ???????? ;
??????? ?????	? ????????? ; ? ????? ????? ; ? membrane ; ? ??????????? ; ? ??????? ; ? cytoplasmic ribonucleoprotein granule ;
?????? ?????	? multicellular organism development ; ? ??????? ?????? ; ? vascular endothelial growth factor receptor signaling pathway ; ? ??????? ; ? GO:0097285 ??? ??????????????? ????? ; ? positive regulation of signal transduction ; ? GO:0072468 ???????? ???? ;
	?????: ????? / ????????
?????????????
	6461
	230126
	ENSG00000107338
	ENSMUSG00000044813
	Q15464
	Q6PD21
	NM_003028
	NM_001033306
	NP_003019
	NP_001028478
	?????????
??????/?????? ?????	??????/?????? ???

??????? ?????????? ??? ???? ????? ?????? ( ??????? : SH2 domain-containing adapter protein B ) ?? ??? ??????? SHB ? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ SHB ≫ ???????? ??????. ^[?]^[?]

??? ??????? ?? ?????????? ?????? ? ?????? ??? ?????????? ^[?] ? C-Src ^[?] ????? ???????-??????? ????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000044813 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics . 24 (3): 615?7. doi : 10.1006/geno.1994.1681 . PMID 7713524 .
↑ "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B" .
↑ ^??? ^??? Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene . 10 (8): 1475?83. PMID 7537362 .

???? ??????? ????? [ ?????? ]

Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene . 10 (8): 1475?83. PMID 7537362 .
Welsh M, Mares J, Karlsson T, Lavergne C, Breant B, Claesson-Welsh L (Jan 1994). "Shb is a ubiquitously expressed Src homology 2 protein" . Oncogene . 9 (1): 19?27. PMID 8302579 .
Karlsson T, Welsh M (Sep 1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene . 13 (5): 955?61. PMID 8806685 .
Welsh M, Songyang Z, Frantz JD, Trub T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins" . Oncogene . 16 (7): 891?901. doi : 10.1038/sj.onc.1201607 . PMID 9484780 .
Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth & Differentiation . 9 (9): 757?66. PMID 9751119 .
Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells" . The Journal of Biological Chemistry . 274 (39): 28050?7. doi : 10.1074/jbc.274.39.28050 . PMID 10488157 .
Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engstrom A, Timpl R, Welsh M, Claesson-Welsh L (Jun 2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood . 95 (11): 3403?11. doi : 10.1182/blood.V95.11.3403 . PMID 10828022 .
Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M (Jun 2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Experimental Cell Research . 257 (2): 245?54. doi : 10.1006/excr.2000.4896 . PMID 10837138 .
Lu L, Anneren C, Reedquist KA, Bos JL, Welsh M (Sep 2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Experimental Cell Research . 259 (2): 370?7. doi : 10.1006/excr.2000.4984 . PMID 10964504 . S2CID 31219631 .
Diakonova M, Gunter DR, Herrington J, Carter-Su C (Mar 2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility" . The Journal of Biological Chemistry . 277 (12): 10669?77. doi : 10.1074/jbc.M111138200 . PMID 11786545 .
Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells" . European Journal of Biochemistry . 269 (13): 3279?88. doi : 10.1046/j.1432-1033.2002.03008.x . PMID 12084069 .
Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (Aug 2002). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells" . Molecular Biology of the Cell . 13 (8): 2881?93. doi : 10.1091/mbc.E02-02-0103 . PMC 117949 . PMID 12181353 .
Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical and Biophysical Research Communications . 296 (4): 929?36. doi : 10.1016/S0006-291X(02)02016-8 . PMID 12200137 .
Holmqvist K, Cross M, Riley D, Welsh M (Feb 2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cellular Signalling . 15 (2): 171?9. doi : 10.1016/S0898-6568(02)00076-1 . PMID 12464388 .
Welsh N, Makeeva N, Welsh M (Nov 2002). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins" . Molecular Medicine . 8 (11): 695?704. doi : 10.1007/BF03402033 . PMC 2039954 . PMID 12520086 .
Holmqvist K, Cross MJ, Rolny C, Hagerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (May 2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration" . The Journal of Biological Chemistry . 279 (21): 22267?75. doi : 10.1074/jbc.M312729200 . PMID 15026417 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000044813 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid7713524-4] Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics . 24 (3): 615?7. doi : 10.1006/geno.1994.1681 . PMID 7713524 .

[entrez-5] "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B" .

[pmid7537362-6] ??? ^??? Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene . 10 (8): 1475?83. PMID 7537362 .

[?]

[?]

[?]

[?]

[?]

[?]