SESN2

SESN2
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	5DJ4 , 5CUF
?????????????
??????? ????	SESN2 , HI95, SES2, SEST2, sestrin 2
????????? ??????	OMIM: 607767 MGI: 2651874 HomoloGene: 12873 GeneCards: SESN2
?????? ?? (???)
????????	???????? ? (???)
?????	132,237,812 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? oxidoreductase activity, acting on peroxide as acceptor ; ? leucine binding ; ? sulfiredoxin activity ; ? oxidoreductase activity ; ? GDP-dissociation inhibitor activity ;
??????? ?????	? ???? ????? ; ? ????????? ; ? ??????? ; ? ????????? ; ? GATOR2 complex ; ? nucleotide-activated protein kinase complex ; ? Atg1/ULK1 kinase complex ; ? TORC2 complex ;
?????? ?????	? mitochondrial DNA metabolic process ; ? mitochondrion organization ; ? protein kinase B signaling ; ? regulation of cAMP-dependent protein kinase activity ; ? response to insulin ; ? response to glucose ; ? glucose homeostasis ; ? glucose import ; ? regulation of response to reactive oxygen species ; ? triglyceride homeostasis ; ? fatty acid beta-oxidation ; ? negative regulation of TORC1 signaling ; ? positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ; ? reactive oxygen species metabolic process ; ? positive regulation of macroautophagy ; ? cellular response to amino acid stimulus ; ? regulation of protein phosphorylation ; ? DNA damage response, signal transduction by p53 class mediator ; ? cellular response to leucine ; ? positive regulation of protein localization to nucleus ; ? cellular oxidant detoxification ; ? negative regulation of cell growth ; ? cellular response to oxidative stress ; ? negative regulation of translation in response to endoplasmic reticulum stress ; ? positive regulation of lipophagy ; ? cellular response to amino acid starvation ; ? cellular response to glucose starvation ; ? cellular response to leucine starvation ; ? regulation of gluconeogenesis ;
	?????: ????? / ????????
?????????????
	83667
	230784
	ENSG00000130766 ; ENSG00000285069
	ENSMUSG00000028893
	P58004
	P58043
	XM_047431519 NM_031459? XM_047431519
	NM_144907
	NP_113647
	NP_659156
	?????????
??????/?????? ?????	??????/?????? ???

?????? ? ( ??????? : Sestrin-2 ) ?? ?? ??? ≪ Hi95 ≫ ?? ?????? ??????? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ SESN2 ≫ ???????? ??????. ^[?]^[?]^[?]

?????? [ ?????? ]

?????? ?? ?? ?????????? NMDA ???? ?? ??? ?????????? ??? ???? ?????????? ≪mTORC1≫ ?? ???? ?????? ?? ??? ?? ??????????? ??? ??????? ??????? ?????????? ????????? ???. ^[?] ????? ??????? NV-5138 ?? ?????? ? ???????????? ??????? ?????? ? ??? ?? ??? ?? ???????????? ≪mTORC1≫ ????? ?????? ? ?? ??? ????? ? ????? ???? ????? ??????? ???. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028893 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (Apr 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Hum Genet . 112 (5?6): 573?80. doi : 10.1007/s00439-003-0917-5 . PMID 12607115 .
↑ Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E (Aug 2002). "Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability" . Oncogene . 21 (39): 6017?31. doi : 10.1038/sj.onc.1205877 . PMID 12203114 .
↑ "Entrez Gene: SESN2 sestrin 2" .
↑ ^??? ^??? Duman RS (2018). "Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide" . F1000Res . 7 . doi : 10.12688/f1000research.14344.1 . PMC 5968361 . PMID 29899972 .

?????????????? ?????????. ≪ SESN2 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ?? ????.

???? ??????? ????? [ ?????? ]

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Budanov AV, Sablina AA, Feinstein E, et al. (2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science . 304 (5670): 596?600. doi : 10.1126/science.1095569 . PMID 15105503 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287?92. doi : 10.1093/embo-reports/kvd058 . PMC 1083732 . PMID 11256614 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422?35. doi : 10.1101/gr.GR1547R . PMC 311072 . PMID 11230166 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000028893 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid12607115-4] Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (Apr 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Hum Genet . 112 (5?6): 573?80. doi : 10.1007/s00439-003-0917-5 . PMID 12607115 .

[pmid12203114-5] Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E (Aug 2002). "Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability" . Oncogene . 21 (39): 6017?31. doi : 10.1038/sj.onc.1205877 . PMID 12203114 .

[entrez-6] "Entrez Gene: SESN2 sestrin 2" .

[pmid29899972-7] ??? ^??? Duman RS (2018). "Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide" . F1000Res . 7 . doi : 10.12688/f1000research.14344.1 . PMC 5968361 . PMID 29899972 .

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