RNF43

RNF43
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	4KNG
?????????????
??????? ????	RNF43 , RNF124, URCC, ring finger protein 43, SSPCS
????????? ??????	OMIM: 612482 MGI: 2442609 HomoloGene: 37742 GeneCards: RNF43
?????? ?? (???)
????????	???????? ?? (???)
?????	87,626,365 bp
?????????? ??
?????? ??????	? metal ion binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? GO:0005110 frizzled binding ; ? GO:1904264? GO:1904822? GO:0090622? GO:0090302 ubiquitin protein ligase activity ; ? GO:0050372 ubiquitin-protein transferase activity ; ? transferase activity ;
??????? ?????	? integral component of membrane ; ? ????? ????? ; ? integral component of plasma membrane ; ? nuclear envelope ; ? endoplasmic reticulum membrane ; ? ???? ????? ; ? ???? ?????????? ; ? membrane ;
?????? ?????	? negative regulation of Wnt signaling pathway ; ? Wnt signaling pathway ; ? Wnt receptor catabolic process ; ? protein ubiquitination ; ? stem cell proliferation ; ? ubiquitin-dependent protein catabolic process ; ? multicellular organism development ;
	?????: ????? / ????????
?????????????
	54894
	207742
	ENSG00000108375
	ENSMUSG00000034177
	Q68DV7
	Q5NCP0
	NM_001305544? NM_001305545? NM_017763? XM_017024800? XM_047436330? XM_047436331? XM_047436332 XM_011524956? NM_001305544? NM_001305545? NM_017763? XM_017024800? XM_047436330? XM_047436331? XM_047436332
	NM_001363437 NM_172448? NM_001363437
	NP_001292474? NP_060233? XP_011523257? XP_011523258? XP_016880289 NP_001292473? NP_001292474? NP_060233? XP_011523257? XP_011523258? XP_016880289
	NP_001350366 NP_766036? NP_001350366
	?????????
??????/?????? ?????	??????/?????? ???

??????? ?????? ?? ????? ???? ( ??????? : Ring finger protein 43 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ RNF43 ≫ ???????? ?????? ?? ??? ?????? ????? ???????? ?? ???? ????.

??????? ??????? ??? ???? ??? ?? ?? ????? ?????????? ??? ??? ???? ??? ? ???????? ?????? ?? ???? ?? ??????? ????????? ?? ??????? ????? ?? ???????? ?? ??????????? ? ?? ????? ????? ????? ???? ?????????? ????. ???? ?????? ?? ??? ??????? ?????????? ???? Wnt ?? ???? ?????? ? ???? ??? ?? ???? ?? ?????? ??????????????? ?????????? ????????? ????? ?? ????? ???? ????? ????? ? ?? ????? ???? ???? ???? ??? ????????? ??????.

??????? ??? ??????????? ?? ??????-N ??? ???????? ???? ??? ?????? ?? ???? ?? ??????? ?? Wnt ?? ???? ??? ?????? ?? ????? ???? ???? ???????? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000034177 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Li S, Lavrijsen M, Bakker A, Magierowski M, Magierowska K, Liu P, Wang W, Peppelenbosch MP, Smits R (2020). "Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers" . Oncogene . 39 (17): 3458?3472. doi : 10.1038/s41388-020-1232-5 . PMID 32103169 .

???? ??????? ????? [ ?????? ]

Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y (November 2004). "A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". Int. J. Oncol . 25 (5): 1343?8. PMID 15492824 .
Sugiura T, Yamaguchi A, Miyamoto K (April 2008). "A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95". Exp. Cell Res . 314 (7): 1519?28. doi : 10.1016/j.yexcr.2008.01.013 . PMID 18313049 .
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription" (PDF) . Biochem. Biophys. Res. Commun . 404 (1): 143?7. doi : 10.1016/j.bbrc.2010.11.082 . hdl : 2115/44929 . PMID 21108931 .
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H (August 2012). "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors". Nature . 488 (7413): 665?9. Bibcode : 2012Natur.488..665K . doi : 10.1038/nature11308 . PMID 22895187 . S2CID 4386072 .
Ryland GL, Hunter SM, Doyle MA, Rowley SM, Christie M, Allan PE, Bowtell DD, Gorringe KL, Campbell IG (February 2013). "RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary" . J. Pathol . 229 (3): 469?76. doi : 10.1002/path.4134 . PMID 23096461 . S2CID 24919944 .
Xing C, Zhou W, Ding S, Xie H, Zhang W, Yang Z, Wei B, Chen K, Su R, Cheng J, Zheng S, Zhou L (January 2013). "Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma" . Mol. Cancer Ther . 12 (1): 94?103. doi : 10.1158/1535-7163.MCT-12-0672 . PMID 23136185 .
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F (July 2013). "Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma" . Proc. Natl. Acad. Sci. U.S.A . 110 (31): 12649?54. Bibcode : 2013PNAS..11012649J . doi : 10.1073/pnas.1307218110 . PMC 3732970 . PMID 23847203 .
Zou Y, Wang F, Liu FY, Huang MZ, Li W, Yuan XQ, Huang OP, He M (November 2013). "RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer". Gene . 531 (1): 112?6. doi : 10.1016/j.gene.2013.08.054 . PMID 24001777 .
Zebisch M, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY (2013). "Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin" . Nat Commun . 4 : 2787. Bibcode : 2013NatCo...4.2787Z . doi : 10.1038/ncomms3787 . PMC 3905715 . PMID 24225776 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000034177 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] Li S, Lavrijsen M, Bakker A, Magierowski M, Magierowska K, Liu P, Wang W, Peppelenbosch MP, Smits R (2020). "Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers" . Oncogene . 39 (17): 3458?3472. doi : 10.1038/s41388-020-1232-5 . PMID 32103169 .

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