PAX3

PAX3
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	3CMY
?????????????
??????? ????	PAX3 , CDHS, HUP2, WS1, WS3, Pax3, paired box 3, PAX-3
????????? ??????	OMIM: 606597 MGI: 97487 HomoloGene: 22494 GeneCards: PAX3
?????? ?? (???)
????????	???????? ? (???)
?????	78,173,771 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? HMG box domain binding ; ? DNA binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? sequence-specific DNA binding ; ? GO:0001131? GO:0001151? GO:0001130? GO:0001204 DNA-binding transcription factor activity ; ? GO:0001200? GO:0001133? GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
??????? ?????	? ???? ????? ; ? ??????????? ;
?????? ?????	? animal organ morphogenesis ; ? GO:0060469? GO:0009371 positive regulation of transcription, DNA-templated ; ? multicellular organism development ; ? muscle organ development ; ? GO:0009373 regulation of transcription, DNA-templated ; ? transcription by RNA polymerase II ; ? ?????? ; ? transcription, DNA-templated ; ? ?????????? ?????? ???? ????? ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? GO:0097285 ??? ??????????????? ????? ;
	?????: ????? / ????????
?????????????
	5077
	18505
	ENSG00000135903
	ENSMUSG00000004872
	P23760
	P24610
	NM_001127366? NM_013942? NM_181457? NM_181458? NM_181459? NM_181460? NM_181461 NM_000438? NM_001127366? NM_013942? NM_181457? NM_181458? NM_181459? NM_181460? NM_181461
	NM_008781 NM_001159520? NM_008781
	NP_001120838? NP_039230? NP_852122? NP_852123? NP_852124? NP_852125? NP_852126 NP_000429? NP_001120838? NP_039230? NP_852122? NP_852123? NP_852124? NP_852125? NP_852126 ; NP_852122.1
	NP_032807 NP_001152992? NP_032807
	?????????
??????/?????? ?????	??????/?????? ???

PAX3 ?? ???? ????? ≪ Paired Box gene 3 ≫ ???? ?? ?? ??? ?? ?? ?????? ??????? ?? ???????? ???????? PAX ?? ??????? ??????. ^[?] ??? ???????? ???????? ?? ????? ? ?????? ? ??? ????. (PAX1 ?? PAX9). ?? ????? ??????? PAX3 ?? PAX7 ????? ????? ????? ????.

?? PAX3 ?? ??? ????? ???? ???????? ? ???? ??? ? ?? ????? ?? ?? ?????? ??? ???? ???? ????. ?? ????? ????? ????? ??????? PAX3 ?? ???????? ???? ?????????? ???? ??????. ^[?]

??? ?? ??? ??? ?? ???? ?????????????? ???????? (?? ?????? ?????? ???? ??? ?? ??????)? ?????? ??????-???? ?? ??????? ? ????? ???????? ^[?] ?? ?????? ???.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000004872 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Stuart ET, Kioussi C, Gruss P (1994). "Mammalian Pax genes". review. Annual Review of Genetics . 28 : 219?36. doi : 10.1146/annurev.ge.28.120194.001251 . PMID 7893124 .
↑ Buckingham M, Relaix F (2007). "The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions". review. Annual Review of Cell and Developmental Biology . 23 : 645?73. doi : 10.1146/annurev.cellbio.23.090506.123438 . PMID 17506689 .
↑ Baldwin CT, Hoth CF, Amos JA, da-Silva EO, Milunsky A (February 1992). "An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome". primary. Nature . 355 (6361): 637?8. doi : 10.1038/355637a0 . PMID 1347149 .

?????????????? ?????????. ≪ PAX3 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

????? ??????? [ ?????? ]

Wachtel M, Schafer BW (2017). "PAX3-FOXO1: Zooming in on an "undruggable" target". review. Seminars in Cancer Biology . doi : 10.1016/j.semcancer.2017.11.006 . PMID 29146205 .
Kubo T, Shimose S, Fujimori J, Furuta T, Ochi M (2015). "Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis". review. Critical Reviews in Oncology/hematology . 96 (1): 46?53. doi : 10.1016/j.critrevonc.2015.04.012 . PMID 26008753 .
Buckingham M, Relaix F (2015). "PAX3 and PAX7 as upstream regulators of myogenesis". review. Seminars in Cell & Developmental Biology . 44 : 115?25. doi : 10.1016/j.semcdb.2015.09.017 . PMID 26424495 .
Eccles MR, He S, Ahn A, Slobbe LJ, Jeffs AR, Yoon HS, Baguley BC (2013). "MITF and PAX3 Play Distinct Roles in Melanoma Cell Migration; Outline of a "Genetic Switch" Theory Involving MITF and PAX3 in Proliferative and Invasive Phenotypes of Melanoma" . review. Frontiers in Oncology . 3 : 229. doi : 10.3389/fonc.2013.00229 . PMC 3769631 . PMID 24062982 .
Olanich ME, Barr FG (2013). "A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma". review. Expert Opinion on Therapeutic Targets . 17 (5): 607?23. doi : 10.1517/14728222.2013.772136 . PMID 23432728 .
Medic S, Ziman M (2009). "PAX3 across the spectrum: from melanoblast to melanoma". review. Critical Reviews in Biochemistry and Molecular Biology . 44 (2?3): 85?97. doi : 10.1080/10409230902755056 . PMID 19401874 .
Kubic JD, Young KP, Plummer RS, Ludvik AE, Lang D (2008). "Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease" . review. Pigment Cell & Melanoma Research . 21 (6): 627?45. doi : 10.1111/j.1755-148X.2008.00514.x . PMC 2979299 . PMID 18983540 .

????? ?? ????? [ ?????? ]

PAX3 protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000004872 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] Stuart ET, Kioussi C, Gruss P (1994). "Mammalian Pax genes". review. Annual Review of Genetics . 28 : 219?36. doi : 10.1146/annurev.ge.28.120194.001251 . PMID 7893124 .

[5] Buckingham M, Relaix F (2007). "The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions". review. Annual Review of Cell and Developmental Biology . 23 : 645?73. doi : 10.1146/annurev.cellbio.23.090506.123438 . PMID 17506689 .

[6] Baldwin CT, Hoth CF, Amos JA, da-Silva EO, Milunsky A (February 1992). "An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome". primary. Nature . 355 (6361): 637?8. doi : 10.1038/355637a0 . PMID 1347149 .

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