NV-5138

NV-5138
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??? ???? ????	??????
???? ??????	???????????? SESN2 ; ??????????? mTORC1
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	??? ?????? (2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid ;
?????? ????????	2095886-80-7 ;
?????? CID	129050791 ;
??????????	65568226 ;
CompTox Dashboard ( EPA )	DTXSID301336354 ;
???????? ?????? ? ???????
????? ???????	C 7 H 13 F 2 N O 2
??? ????	??????? g·mol ?1
??? ?? ???? ( ?????? )	Interactive image ;
	SMILES CC(C)(CC(C(=O)O)N)C(F)F ;
	InChI InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1 ; Key:HRFIMCJTDKEPPV-BYPYZUCNSA-N ;

NV-5138 ^[?] ?? ?????? ???? ?????? ??? ?? ???? ???? ≪?????? ???????≫ ???? ????? ?????? ??????? ???? ?? ??? ???? ???. ^[?]^[?]^[?] ??? ????? ??????????? ?????? ? ??????? ???? ?????????? ????? ≪mTORC1≫ ??? ? ??? ??? ?? ?? ???? ????? ?? ??????? ?????? ? ?? ?? ???? ????? ?????? ????? ????? ???? ????? ??????. ^[?]^[?]^[?] ???? ?????????? ????? ≪mTORC1≫? ???? ????? ??? ?? ????? ?????? (?? ?????????? NMDA ) ?? ??? ?????????? ??? ??? ??????? ??????? ?????????? ????????? ???? ??????. ^[?]^[?] ?? ??????? ??????? ?????? ?????? ?? ?? ?????? ?? ??? ???? ???????? ???? ?????????? ?????? ?? ???????? ? ???? ??????????? ?? ??? ?????????? ????. ^[?]^[?] ????? ??????? ??? ???? ??? ???? ????? ??? ??????? ?????? ?????????? ???? ?? ??? (BDNF) ???. ^[?] ????? ????????? ??? ???? ?? ??? ?????? ??????? ??? (?? ? ???) ? ???? ????? ?????? ????. ^[?]^[?] ?? ????? ????????? ??????? ??????????? ???? ?? ?? ??? ?? ?? ??? ???? ?? ????????? ?????? ?? ??? ????? ??????? ??? ^[?] ? ?? ?????? ???? ??????? ??? ??? ?? ???? ????? ?????? ??????? ???? ????? ????? ^[?] ? ?? ??? ???????? ???????? ????? ????? ? ????????????? ?? ????? ?????. ^[?]

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↑ ^??? ^??? ^??? ^??? ^??? ^??? ^??? ^??? Duman RS (2018). "Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide" . F1000Res . 7 : 659. doi : 10.12688/f1000research.14344.1 . PMC 5968361 . PMID 29899972 .
↑ Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica; O’Neill, David; Vlasuk, George P.; Saiah, Eddine (11 March 2019). "Discovery of NV-5138, the first selective Brain mTORC1 activator" . Scientific Reports . 9 (1). Bibcode : 2019NatSR...9.4107S . doi : 10.1038/s41598-019-40693-5 . PMC 6412019 . PMID 30858438 .
↑ ^??? ^??? "Research programme: mTORC1 modulators - Navitor Pharmaceuticals - AdisInsight" . adisinsight.springer.com .
↑ ^??? ^??? ^??? ^??? ^??? "Sestrin 2 Modulator NV-5138 Shows Ketamine-Like Rapid Antidepressant Effects via Direct Activation of mTORC1 Signaling" in "ACNP 56th Annual Meeting: Poster Session I, December 4, 2017" . Neuropsychopharmacology . 42 (1): S111?S293. November 2017. doi : 10.1038/npp.2017.264 . PMC 5719065 .
↑ Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM (January 2016). "Sestrin2 is a leucine sensor for the mTORC1 pathway" . Science . 351 (6268): 43?8. Bibcode : 2016Sci...351...43W . doi : 10.1126/science.aab2674 . PMC 4698017 . PMID 26449471 .
↑ "Navitor's Three Phase 1 Studies for NV-5138 Show Antidepressant Effects and Biomarker Impact, Supporting Further Development of Direct Activator of mTORC1 in Depression" .

?????????????? ?????????. ≪ NV-5138 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ?? ????.

??? ?? ?????? ??? ??????? ???? ?? ????????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[pmid29899972-1] ??? ^??? ^??? ^??? ^??? ^??? ^??? ^??? Duman RS (2018). "Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide" . F1000Res . 7 : 659. doi : 10.12688/f1000research.14344.1 . PMC 5968361 . PMID 29899972 .

[2] Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica; O’Neill, David; Vlasuk, George P.; Saiah, Eddine (11 March 2019). "Discovery of NV-5138, the first selective Brain mTORC1 activator" . Scientific Reports . 9 (1). Bibcode : 2019NatSR...9.4107S . doi : 10.1038/s41598-019-40693-5 . PMC 6412019 . PMID 30858438 .

[AdisInsight-3] ??? ^??? "Research programme: mTORC1 modulators - Navitor Pharmaceuticals - AdisInsight" . adisinsight.springer.com .

[DumanKato2017-4] ??? ^??? ^??? ^??? ^??? "Sestrin 2 Modulator NV-5138 Shows Ketamine-Like Rapid Antidepressant Effects via Direct Activation of mTORC1 Signaling" in "ACNP 56th Annual Meeting: Poster Session I, December 4, 2017" . Neuropsychopharmacology . 42 (1): S111?S293. November 2017. doi : 10.1038/npp.2017.264 . PMC 5719065 .

[pmid26449471-5] Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM (January 2016). "Sestrin2 is a leucine sensor for the mTORC1 pathway" . Science . 351 (6268): 43?8. Bibcode : 2016Sci...351...43W . doi : 10.1126/science.aab2674 . PMC 4698017 . PMID 26449471 .

[BioSpace2019-6] "Navitor's Three Phase 1 Studies for NV-5138 Show Antidepressant Effects and Biomarker Impact, Supporting Further Development of Direct Activator of mTORC1 in Depression" .

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