NOD2

NOD2
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	5IRL , 5IRM , 5IRN
?????????????
??????? ????	NOD2 , ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
????????? ??????	OMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2
?????? ?? (???)
????????	???????? ? (???)
?????	89,415,102 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? Hsp90 protein binding ; ? nucleotide binding ; ? Hsp70 protein binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? peptidoglycan binding ; ? enzyme binding ; ? actin binding ; ? CARD domain binding ; ? ATP binding ; ? protein kinase binding ; ? muramyl dipeptide binding ; ? GO:0032403 protein-containing complex binding ;
??????? ?????	? ????????? ; ? ??????? ; ? ??????? ; ? membrane ; ? ????? ????? ; ? cell surface ; ? basolateral plasma membrane ; ? COP9 signalosome ; ? ????? ????? ; ? ?????? ???? ; ? ????????? ; ? GO:0009327 protein-containing complex ;
?????? ?????	? positive regulation of prostaglandin-endoperoxide synthase activity ; ? regulation of apoptotic process ; ? defense response ; ? detection of biotic stimulus ; ? cytokine production involved in immune response ; ? positive regulation of cytokine production involved in inflammatory response ; ? GO:0007243 intracellular signal transduction ; ? detection of muramyl dipeptide ; ? positive regulation of interleukin-10 production ; ? positive regulation of epithelial cell proliferation ; ? immune system process ; ? GO:1900490 positive regulation of oxidoreductase activity ; ? response to muramyl dipeptide ; ? positive regulation of prostaglandin-E synthase activity ; ? positive regulation of JNK cascade ; ? positive regulation of nitric-oxide synthase biosynthetic process ; ? positive regulation of NIK/NF-kappaB signaling ; ? positive regulation of phosphatidylinositol 3-kinase activity ; ? positive regulation of gamma-delta T cell activation ; ? cellular response to muramyl dipeptide ; ? JNK cascade ; ? negative regulation of macrophage apoptotic process ; ? positive regulation of dendritic cell antigen processing and presentation ; ? nucleotide-binding oligomerization domain containing 2 signaling pathway ; ? maintenance of gastrointestinal epithelium ; ? defense response to bacterium ; ? positive regulation of NF-kappaB transcription factor activity ; ? positive regulation of interleukin-8 production ; ? detection of bacterium ; ? positive regulation of interleukin-1 beta production ; ? regulation of inflammatory response ; ? positive regulation of interleukin-6 production ; ? protein complex oligomerization ; ? positive regulation of tumor necrosis factor production ; ? positive regulation of ERK1 and ERK2 cascade ; ? positive regulation of I-kappaB kinase/NF-kappaB signaling ; ? positive regulation of B cell activation ; ? positive regulation of interleukin-17 production ; ? positive regulation of type 2 immune response ; ? nucleotide-binding oligomerization domain containing signaling pathway ; ? positive regulation of stress-activated MAPK cascade ; ? positive regulation of Notch signaling pathway ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? GO:1904579 cellular response to organic cyclic compound ; ? positive regulation of cell population proliferation ; ? ?????? ????? ???? ; ? response to nutrient ; ? positive regulation of dendritic cell cytokine production ; ? positive regulation of protein K63-linked ubiquitination ; ? cellular response to peptidoglycan ; ? positive regulation of MAP kinase activity ; ? interleukin-1-mediated signaling pathway ; ? cellular response to lipopolysaccharide ;
	?????: ????? / ????????
?????????????
	64127
	257632
	ENSG00000167207
	ENSMUSG00000055994
	Q9HC29
	Q80SY9
	NM_001293557? NM_022162? XM_006721242? XM_006721243? XM_011523259? XM_011523260? XM_011523261? XR_429725? XR_429726? XM_017023535? XM_017023536? XM_017023537? XM_017023538? NM_001370466? NR_163434 XR_933387? NM_001293557? NM_022162? XM_006721242? XM_006721243? XM_011523259? XM_011523260? XM_011523261? XR_429725? XR_429726? XM_017023535? XM_017023536? XM_017023537? XM_017023538? NM_001370466? NR_163434
	XM_006531028? XM_006531029? XM_011248390? XM_036154050? XM_036154051 NM_145857? XM_006531028? XM_006531029? XM_011248390? XM_036154050? XM_036154051
	NP_071445? XP_006721305? XP_006721306? XP_011521561? XP_011521562? XP_011521563? XP_016879024? XP_016879025? XP_016879026? XP_016879027? NP_001357395 NP_001280486? NP_071445? XP_006721305? XP_006721306? XP_011521561? XP_011521562? XP_011521563? XP_016879024? XP_016879025? XP_016879026? XP_016879027? NP_001357395
	XP_006531091? XP_006531092? XP_011246692? XP_036009943? XP_036009944 NP_665856? XP_006531091? XP_006531092? XP_011246692? XP_036009943? XP_036009944
	?????????
??????/?????? ?????	??????/?????? ???

??????? ?????? ? ?????????????? ???? ????? ? ?????????? ?? ????????? ( ??????? : Nucleotide-binding oligomerization domain-containing protein 2 ) ?? ?? ??????? ????? ????? ≪ ??????? ?????? ?? ???? ?????? ??? ?????? ≫ (CARD15) ? ≪ ??????? ?????? ? ?????? ??????? ???? ≫ (IBD1) ?? ?????? ??????? ???????? ??? ?? ?? ????? ???? ?? ≪NOD2≫ (???? ?? ??? ???????? ?? ) ??? ??????. ^[?]^[?]

??? ??????? ??? ???? ?? ?????? ????? ???? ?????? ? ????? ??????? ????????? ?????? ( ???????????? ) ? ????? ????? ????? ???.

NOD2 ??? ?? ?????????? ??????? ???? ?? ???? ???? ??? ? ??????? ???????? ?? ?? ?? ??????? ???? ????????? ???? ??????? ??????? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000055994 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Gilberts EC, Greenstein AJ, Katsel P, Harpaz N, Greenstein RJ (Dec 1994). "Molecular evidence for two forms of Crohn disease" . Proceedings of the National Academy of Sciences of the United States of America . 91 (26): 12721?4. doi : 10.1073/pnas.91.26.12721 . PMC 45511 . PMID 7809109 .
↑ Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G (Feb 1996). "Mapping of a susceptibility locus for Crohn's disease on chromosome 16". Nature . 379 (6568): 821?3. doi : 10.1038/379821a0 . PMID 8587604 .
↑ Kufer TA, Banks DJ, Philpott DJ (Aug 2006). "Innate immune sensing of microbes by Nod proteins". Annals of the New York Academy of Sciences . 1072 : 19?27. doi : 10.1196/annals.1326.020 . PMID 17057187 .

?????????????? ?????????. ≪ NOD2 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000055994 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid7809109-4] Gilberts EC, Greenstein AJ, Katsel P, Harpaz N, Greenstein RJ (Dec 1994). "Molecular evidence for two forms of Crohn disease" . Proceedings of the National Academy of Sciences of the United States of America . 91 (26): 12721?4. doi : 10.1073/pnas.91.26.12721 . PMC 45511 . PMID 7809109 .

[pmid8587604-5] Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G (Feb 1996). "Mapping of a susceptibility locus for Crohn's disease on chromosome 16". Nature . 379 (6568): 821?3. doi : 10.1038/379821a0 . PMID 8587604 .

[pmid17057187-6] Kufer TA, Banks DJ, Philpott DJ (Aug 2006). "Innate immune sensing of microbes by Nod proteins". Annals of the New York Academy of Sciences . 1072 : 19?27. doi : 10.1196/annals.1326.020 . PMID 17057187 .

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