NITD008

NITD008
???????? ??????
??????? ?????	NITD008
????????
	??? ?????? (2 R ,3 R ,4 R ,5 R )-2-(4-Amino-7 H -pyrrolo[2,3- d ]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol ;
?????? ????????	1044589-82-3 ;
?????? CID	44633776 ;
CompTox Dashboard ( EPA )	DTXSID701159354 ;
???????? ?????? ? ???????
????? ???????	C 13 H 14 N 4 O 4
??? ????	??????? g·mol ?1
??? ?? ???? ( ?????? )	Interactive image ;
	SMILES C#C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC3=C2N=CN=C3N)CO)O)O ;

NITD008 ?? ????? ?? ????? ? ?????? ??????? ??? ?? ?? ????? ????? ??????? ????????? ??????????? ????? ?? ? ????? ???????? ?????????? ???? ????? ?? ???? ? ????? ??? ???? ? ?? ??? ? ????? ??????? ????? ?????? ??? ?????? ???? ????????? ?? ?????????????? ????? ? ????? ???? ?? ??? ???? ????????. ^[?]^[?]^[?]

?? ?????????? ?????????? ????????? ?? ??? ??????? ??? ???? ????? ??? ????? ???? ?? ? ?????????? ?????? ?? ??? ????? ????? ??? ??? ?????? ?? ?? ???????? ?? ????? ??????? ??? ?????? ????????? ?? ?????? ??????? ??????. ^[?]

???????? ?????? [ ?????? ]

MK-608

????? [ ?????? ]

↑ Yin, Z.; Chen, Y.-L.; Schul, W.; Wang, Q.-Y.; Gu, F.; Duraiswamy, J.; Kondreddi, R. R.; Niyomrattanakit, P.; Lakshminarayana, S. B.; Goh, A.; Xu, H. Y.; Liu, W.; Liu, B.; Lim, J. Y. H.; Ng, C. Y.; Qing, M.; Lim, C. C.; Yip, A.; Wang, G.; Chan, W. L.; Tan, H. P.; Lin, K.; Zhang, B.; Zou, G.; Bernard, K. A.; Garrett, C.; Beltz, K.; Dong, M.; Weaver, M.; et al. (2009). "An adenosine nucleoside inhibitor of dengue virus". Proceedings of the National Academy of Sciences . 106 (48): 20435?20439. Bibcode : 2009PNAS..10620435Y . doi : 10.1073/pnas.0907010106 .
↑ Lo, Michael K.; Shi, Pei-Yong; Chen, Yen-Liang; Flint, Mike; Spiropoulou, Christina F. (2016). "In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses" . Antiviral Research . 130 : 46?49. doi : 10.1016/j.antiviral.2016.03.013 . PMC 5096641 . PMID 27016316 .
↑ Deng, Yong-Qiang; Zhang, Na-Na; Li, Chun-Feng; Tian, Min; Hao, Jia-Nan; Xie, Xu-Ping; Shi, Pei-Yong; Qin, Cheng-Feng (2016). "Adenosine Analog NITD008 is a Potent Inhibitor of Zika Virus". Open Forum Infectious Diseases . 3 (4): ofw175. doi : 10.1093/ofid/ofw175 .
↑ Nelson, Jacob; Roe, Kelsey; Orillo, Beverly; Shi, Pei-Yong; Verma, Saguna (2015). "Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection" . Antiviral Research . 122 : 39?45. doi : 10.1016/j.antiviral.2015.07.008 . PMC 4853296 . PMID 26225754 .

?????????????? ?????????. ≪ NITD008 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

??? ?? ?????? ??? ??????? ???? ?? ????????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[1] Yin, Z.; Chen, Y.-L.; Schul, W.; Wang, Q.-Y.; Gu, F.; Duraiswamy, J.; Kondreddi, R. R.; Niyomrattanakit, P.; Lakshminarayana, S. B.; Goh, A.; Xu, H. Y.; Liu, W.; Liu, B.; Lim, J. Y. H.; Ng, C. Y.; Qing, M.; Lim, C. C.; Yip, A.; Wang, G.; Chan, W. L.; Tan, H. P.; Lin, K.; Zhang, B.; Zou, G.; Bernard, K. A.; Garrett, C.; Beltz, K.; Dong, M.; Weaver, M.; et al. (2009). "An adenosine nucleoside inhibitor of dengue virus". Proceedings of the National Academy of Sciences . 106 (48): 20435?20439. Bibcode : 2009PNAS..10620435Y . doi : 10.1073/pnas.0907010106 .

[2] Lo, Michael K.; Shi, Pei-Yong; Chen, Yen-Liang; Flint, Mike; Spiropoulou, Christina F. (2016). "In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses" . Antiviral Research . 130 : 46?49. doi : 10.1016/j.antiviral.2016.03.013 . PMC 5096641 . PMID 27016316 .

[3] Deng, Yong-Qiang; Zhang, Na-Na; Li, Chun-Feng; Tian, Min; Hao, Jia-Nan; Xie, Xu-Ping; Shi, Pei-Yong; Qin, Cheng-Feng (2016). "Adenosine Analog NITD008 is a Potent Inhibitor of Zika Virus". Open Forum Infectious Diseases . 3 (4): ofw175. doi : 10.1093/ofid/ofw175 .

[4] Nelson, Jacob; Roe, Kelsey; Orillo, Beverly; Shi, Pei-Yong; Verma, Saguna (2015). "Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection" . Antiviral Research . 122 : 39?45. doi : 10.1016/j.antiviral.2015.07.008 . PMC 4853296 . PMID 26225754 .

[?]

[?]

[?]

[?]