N-Myc

MYCN
?????????????
??????? ????	MYCN , MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP
????????? ??????	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN
?????? ?? (???)
????????	???????? ?? (???)
?????	12,991,915 bp
????? ????? RNA
	; ; ; ;
	More reference expression data
?????????? ??
?????? ??????	? DNA binding ; ? protein dimerization activity ; ? GO:0001131? GO:0001151? GO:0001130? GO:0001204 DNA-binding transcription factor activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; ? GO:0001077? GO:0001212? GO:0001213? GO:0001211? GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; ? kinase binding ; ? GO:0001200? GO:0001133? GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
??????? ?????	? ???????? ; ? ???? ????? ; ? ???? ;
?????? ?????	? GO:0009373 regulation of transcription, DNA-templated ; ? GO:0044324? GO:0003256? GO:1901213? GO:0046019? GO:0046020? GO:1900094? GO:0061216? GO:0060994? GO:1902064? GO:0003258? GO:0072212 regulation of transcription by RNA polymerase II ; ? transcription, DNA-templated ; ? GO:1901313 positive regulation of gene expression ; ? negative regulation of gene expression ; ? positive regulation of production of miRNAs involved in gene silencing by miRNA ; ? transcription by RNA polymerase II ; ? cartilage condensation ; ? positive regulation of mesenchymal cell proliferation ; ? positive regulation of cell population proliferation ; ? positive regulation of cell death ; ? lung development ; ? embryonic digit morphogenesis ; ? regulation of inner ear auditory receptor cell differentiation ; ? GO:0060469? GO:0009371 positive regulation of transcription, DNA-templated ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? embryonic skeletal system morphogenesis ; ? negative regulation of astrocyte differentiation ; ? branching morphogenesis of an epithelial tube ; ? negative regulation of reactive oxygen species metabolic process ;
	?????: ????? / ????????
?????????????
	4613
	18109
	ENSG00000134323
	ENSMUSG00000037169
	P04198
	P03966
	NM_001293228? NM_001293231? NM_001293233? XM_047444434 NM_005378? NM_001293228? NM_001293231? NM_001293233? XM_047444434
	NM_008709
	NP_001280160? NP_001280162? NP_005369 NP_001280157? NP_001280160? NP_001280162? NP_005369
	NP_032735
	?????????
??????/?????? ?????	??????/?????? ???

??????? ?????-?????? N-Myc ( ??????? : N-myc proto-oncogene protein ) ?? ??????? ??????-????-?????? ?????? ?? ?? ?? ??????? ??????? ≪N-Myc≫ ? ≪bHLHe37≫ ?? ?????? ??????? ?? ??????? ??? ?? ?? ????? ???? ?? ≪ MYCN ≫ ??????? ??????.

??? ?? ??? ?? ????? ???????? MYCN ??? ?? ????? ?? ????????? ??????? ???? ? ?? ????? ??????-????-?????? ?????? ?????. ??????? ????? ??? ???? ??? ??? ?? ???? ???? ??? ???? ? ???????? ????? ?? ???????? ? ???????? ?? ??????? ?????? ?? ?????? ?????? ????? ????. (???????? ????). ^[?] ??????? N-Myc ?? ??? ???? ?? ?????? ???? ????? ?????? ? ???? ??? ? ????? ????? ??? ????? ???. ^[?]

????? ?????? ?? ????? ??? ?? ??? N-Myc ??? ???? ????? ??????. ?????? ???? ??? ??????? ?? ???????? ???????? ??????? ???????????? ?? ?????? ????? ???? ?? ???? ?? ????? ? ?????? ?????? ?? ?? ???????? ?? ???????????? ????? ???. ^[?]^[?]^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)" .
↑ Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation" . Genes Dev . 16 (20): 2699?712. doi : 10.1101/gad.1021202 . PMC 187459 . PMID 12381668 .
↑ Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet . 4 (2): 191?4. doi : 10.1038/ng0693-191 . PMID 8102299 .
↑ Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas" . Proc. Natl. Acad. Sci. U.S.A . 82 (11): 3736?40. doi : 10.1073/pnas.82.11.3736 . PMC 397862 . PMID 2582423 .
↑ Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science . 224 (4653): 1121?4. doi : 10.1126/science.6719137 . PMID 6719137 .

?????????????? ?????????. ≪ N-Myc ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ????? ????.

???? ??????? ????? [ ?????? ]

Luscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene . 277 (1?2): 1?14. doi : 10.1016/S0378-1119(01)00697-7 . PMID 11602341 .
Hagiwara T, Nakaya K, Nakamura Y, Nakajima H, Nishimura S, Taya Y (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II". Eur. J. Biochem . 209 (3): 945?50. doi : 10.1111/j.1432-1033.1992.tb17367.x . PMID 1425701 .
Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)" . Nucleic Acids Res . 20 (5): 1165. doi : 10.1093/nar/20.5.1165 . PMC 312136 . PMID 1549498 .
Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts" . Mol. Cell. Biol . 10 (8): 4180?91. PMC 360949 . PMID 1695323 .
Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science . 251 (4998): 1211?7. doi : 10.1126/science.2006410 . PMID 2006410 .
Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas" . Proc. Natl. Acad. Sci. U.S.A . 82 (11): 3736?40. doi : 10.1073/pnas.82.11.3736 . PMC 397862 . PMID 2582423 .
Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation". Oncogene . 2 (4): 399?402. PMID 2834684 .
Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene" . Proc. Natl. Acad. Sci. U.S.A . 83 (6): 1772?6. doi : 10.1073/pnas.83.6.1772 . PMC 323166 . PMID 2869488 .
Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene" . Nucleic Acids Res . 13 (7): 2545?58. doi : 10.1093/nar/13.7.2545 . PMC 341174 . PMID 2987858 .
Slamon DJ, Boone TC, Seeger RC, Keith DE, Chazin V, Lee HC, Souza LM (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene". Science . 232 (4751): 768?72. doi : 10.1126/science.3008339 . PMID 3008339 .
Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes" . Nucleic Acids Res . 15 (12): 4761?70. doi : 10.1093/nar/15.12.4761 . PMC 305916 . PMID 3299258 .
Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC" . Mol. Cell. Biol . 7 (12): 4266?72. PMC 368108 . PMID 3437890 .
Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc". Nature . 319 (6048): 73?7. doi : 10.1038/319073a0 . PMID 3510398 .
Grady EF, Schwab M, Rosenau W (1987). "Expression of N-myc and c-src during the development of fetal human brain". Cancer Res . 47 (11): 2931?6. PMID 3552210 .
Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA" . Mol. Cell. Biol . 6 (12): 4450?7. PMC 367228 . PMID 3796607 .
Brodeur GM, Seeger RC (1986). "Gene amplification in human neuroblastomas: basic mechanisms and clinical implications". Cancer Genet. Cytogenet . 19 (1?2): 101?11. doi : 10.1016/0165-4608(86)90377-8 . PMID 3940169 .
Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S (1983). "Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes" . Proc. Natl. Acad. Sci. U.S.A . 80 (13): 4069?73. doi : 10.1073/pnas.80.13.4069 . PMC 394202 . PMID 6575396 .
Schwab M, Varmus HE, Bishop JM, Grzeschik KH, Naylor SL, Sakaguchi AY, Brodeur G, Trent J (1984). "Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc". Nature . 308 (5956): 288?91. doi : 10.1038/308288a0 . PMID 6700732 .

????? ?? ????? [ ?????? ]

MYCN protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)" .

[5] Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation" . Genes Dev . 16 (20): 2699?712. doi : 10.1101/gad.1021202 . PMC 187459 . PMID 12381668 .

[pmid8102299-6] Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet . 4 (2): 191?4. doi : 10.1038/ng0693-191 . PMID 8102299 .

[7] Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas" . Proc. Natl. Acad. Sci. U.S.A . 82 (11): 3736?40. doi : 10.1073/pnas.82.11.3736 . PMC 397862 . PMID 2582423 .

[8] Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science . 224 (4653): 1121?4. doi : 10.1126/science.6719137 . PMID 6719137 .

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