MLST8

MLST8
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	4JSN , 4JSP , 4JSV , 4JSX , 4JT5 , 4JT6 , 5FLC
?????????????
??????? ????	MLST8 , GBL, GbetaL, LST8, POP3, WAT1, MTOR associated protein, LST8 homolog
????????? ??????	OMIM: 612190 MGI: 1929514 HomoloGene: 6833 GeneCards: MLST8
?????? ?? (???)
????????	???????? ?? (???)
?????	24,698,052 bp
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? protein serine/threonine kinase activator activity ;
??????? ?????	? ????????? ; ? ??????????? ; ? ??????? ; ? TORC1 complex ; ? TORC2 complex ;
?????? ?????	? positive regulation of actin filament polymerization ; ? regulation of actin cytoskeleton organization ; ? GO:0043087? GO:0032313? GO:0032319? GO:0032314? GO:0043088 regulation of GTPase activity ; ? positive regulation of peptidyl-tyrosine phosphorylation ; ? regulation of cellular response to heat ; ? TORC1 signaling ; ? positive regulation of protein serine/threonine kinase activity ; ? regulation of macroautophagy ; ? activation of protein kinase B activity ; ? TOR signaling ; ? positive regulation of TOR signaling ;
	?????: ????? / ????????
?????????????
	64223
	56716
	ENSG00000167965
	ENSMUSG00000024142
	Q9BVC4
	Q9DCJ1
	NM_001199174? NM_001199175? NM_022372? XM_005255475? XM_005255479? NM_001352057? NM_001352059? NM_001352060? NR_147904? NR_147905? NR_147906? NR_147907? XM_047434466? XM_047434467 NM_001199173? NM_001199174? NM_001199175? NM_022372? XM_005255475? XM_005255479? NM_001352057? NM_001352059? NM_001352060? NR_147904? NR_147905? NR_147906? NR_147907? XM_047434466? XM_047434467
	NM_001252464? NM_001252465? NM_019988? XM_006524678? XM_006524679? XM_017317586? XM_017317587? XM_030249920? XM_030249921 NM_001252463? NM_001252464? NM_001252465? NM_019988? XM_006524678? XM_006524679? XM_017317586? XM_017317587? XM_030249920? XM_030249921
	NP_001186103? NP_001186104? NP_071767? XP_005255532? XP_005255536? XP_016879037? XP_016879038? XP_016879039? XP_016879040? XP_016879041? NP_001338986? NP_001338988? NP_001338989? XP_024306145? XP_024306146 NP_001186102? NP_001186103? NP_001186104? NP_071767? XP_005255532? XP_005255536? XP_016879037? XP_016879038? XP_016879039? XP_016879040? XP_016879041? NP_001338986? NP_001338988? NP_001338989? XP_024306145? XP_024306146
	NP_001239393? NP_001239394? NP_064372? XP_006524741? XP_006524742? XP_017173075? XP_017173076 NP_001239392? NP_001239393? NP_001239394? NP_064372? XP_006524741? XP_006524742? XP_017173075? XP_017173076
	?????????
??????/?????? ?????	??????/?????? ???

?????? ???? ?????? ??????????? ??????? ????????? ( ??????? : Target of rapamycin complex subunit LST8 ) ????? ?? ≪ ??????? ? ????? ?? ?????????? ?????????? ≫ ?? ??????? ??? ?? ?? ????? ???? ?? ≪ MLST8 ≫ ???????? ??????. ^[?] ??? ?????? ??????? ?? ?? ?????? ???????? ≪mTORC1≫ ? ≪mTORC2≫ ??? ?? ?? ????? ??? ? ???? ???? ?? ???? ?? ???? ????? ?????? ??????-???? ? ???????? ??????? ??? ?????. ^[?] ????? ?? ≪ MLST8 ≫ ?? ????? ?????? ???????? mTORC ??????? ???? ? ???? ??? ?????? ??????? ? ???? ?????? ????? ?? ???????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024142 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Entrez Gene: MTOR associated protein" .
↑ "UniProtKB ? Q9BVC4 (LST8_HUMAN)" .
↑ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression" . PLOS ONE . 10 (4): e0119015. Bibcode : 2015PLoSO..1019015K . doi : 10.1371/journal.pone.0119015 . PMC 4408021 . PMID 25906254 .

?????????????? ?????????. ≪ MLST8 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ??????? ????.

???? ??????? ????? [ ?????? ]

Ali SM, Sabatini DM (2005). "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site" . J. Biol. Chem . 280 (20): 19445?8. doi : 10.1074/jbc.C500125200 . PMID 15809305 .
Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (2001). "Insulin regulation of a novel WD-40 repeat protein in adipocytes" . J. Endocrinol . 168 (2): 325?32. doi : 10.1677/joe.0.1680325 . PMID 11182770 .
Long X, Lin Y, Ortiz-Vega S, et al. (2005). "Rheb binds and regulates the mTOR kinase" . Curr. Biol . 15 (8): 702?13. doi : 10.1016/j.cub.2005.02.053 . PMID 15854902 . S2CID 3078706 .
Kaizuka T, Hara T, Oshiro N, et al. (2010). "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly" . J. Biol. Chem . 285 (26): 20109?16. doi : 10.1074/jbc.M110.121699 . PMC 2888423 . PMID 20427287 .
Loewith R, Jacinto E, Wullschleger S, et al. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control" . Mol. Cell . 10 (3): 457?68. doi : 10.1016/S1097-2765(02)00636-6 . PMID 12408816 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55?65. doi : 10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Sarbassov DD, Sabatini DM (2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex" . J. Biol. Chem . 280 (47): 39505?9. doi : 10.1074/jbc.M506096200 . PMID 16183647 .
Oshiro N, Yoshino K, Hidayat S, et al. (2004). "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function" . Genes Cells . 9 (4): 359?66. doi : 10.1111/j.1356-9597.2004.00727.x . PMID 15066126 . S2CID 24814691 .
Inoki K, Ouyang H, Li Y, Guan KL (2005). "Signaling by target of rapamycin proteins in cell growth control" . Microbiol. Mol. Biol. Rev . 69 (1): 79?100. doi : 10.1128/MMBR.69.1.79-100.2005 . PMC 1082789 . PMID 15755954 .
Behrends C, Sowa ME, Gygi SP, Harper JW (2010). "Network organization of the human autophagy system" . Nature . 466 (7302): 68?76. Bibcode : 2010Natur.466...68B . doi : 10.1038/nature09204 . PMC 2901998 . PMID 20562859 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 .
Kawai S, Enzan H, Hayashi Y, et al. (2003). "Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers". Virchows Arch . 443 (1): 78?86. doi : 10.1007/s00428-003-0804-4 . PMID 12719976 . S2CID 21552704 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. Bibcode : 2002PNAS...9916899M . doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Kim DH, Sarbassov DD, Ali SM, et al. (2003). "GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR" . Mol. Cell . 11 (4): 895?904. doi : 10.1016/S1097-2765(03)00114-X . PMID 12718876 .
Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol . 6 (11): 1122?8. doi : 10.1038/ncb1183 . PMID 15467718 . S2CID 13831153 .
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science . 307 (5712): 1098?101. Bibcode : 2005Sci...307.1098S . doi : 10.1126/science.1106148 . PMID 15718470 . S2CID 45837814 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024142 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[entrez-4] "Entrez Gene: MTOR associated protein" .

[5] "UniProtKB ? Q9BVC4 (LST8_HUMAN)" .

[6] Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression" . PLOS ONE . 10 (4): e0119015. Bibcode : 2015PLoSO..1019015K . doi : 10.1371/journal.pone.0119015 . PMC 4408021 . PMID 25906254 .

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