MAPKAP1

MAPKAP1
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	3VOQ
?????????????
??????? ????	MAPKAP1 , JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
????????? ??????	OMIM: 610558 MGI: 2444554 HomoloGene: 11473 GeneCards: MAPKAP1
?????? ?? (???)
????????	???????? ? (???)
?????	34,624,950 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? phosphatidylinositol-3,5-bisphosphate binding ; ? phosphatidylinositol-3,4-bisphosphate binding ; ? phosphatidic acid binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? phosphatidylinositol-4,5-bisphosphate binding ; ? protein kinase binding ; ? phosphatidylinositol-3,4,5-trisphosphate binding ;
??????? ?????	? ?????? ???? ; ? membrane ; ? ????? ????? ; ? ??????????? ; ? GO:0016023 cytoplasmic vesicle ; ? ???? ????? ; ? ??????? ; ? TORC2 complex ; ? ????????? ;
?????? ?????	? substantia nigra development ; ? negative regulation of Ras protein signal transduction ; ? establishment or maintenance of actin cytoskeleton polarity ; ? stress-activated protein kinase signaling cascade ; ? TORC2 signaling ; ? activation of protein kinase B activity ; ? positive regulation of peptidyl-serine phosphorylation ; ? regulation of cellular response to oxidative stress ;
	?????: ????? / ????????
?????????????
	79109
	227743
	ENSG00000119487
	ENSMUSG00000038696
	Q9BPZ7
	Q8BKH7
	NM_001006618? NM_001006619? NM_001006620? NM_001006621? NM_024117 NM_001006617? NM_001006618? NM_001006619? NM_001006620? NM_001006621? NM_024117
	NM_001290626? NM_177345? XM_006497975? XM_006497978? XM_006497980? XM_006497982? XM_006497983? XM_011239082? XM_011239083? XM_011239084? XM_011239085? XM_017317443? XM_017317446? NM_001362919? NM_001362920? NM_001362921 NM_001290625? NM_001290626? NM_177345? XM_006497975? XM_006497978? XM_006497980? XM_006497982? XM_006497983? XM_011239082? XM_011239083? XM_011239084? XM_011239085? XM_017317443? XM_017317446? NM_001362919? NM_001362920? NM_001362921
	NP_001006619? NP_001006620? NP_001006621? NP_001006622? NP_077022 NP_001006618? NP_001006619? NP_001006620? NP_001006621? NP_001006622? NP_077022
	NP_001277555? NP_796319? XP_006498038? XP_006498041? XP_006498043? XP_006498046? XP_011237385? XP_011237386? NP_001349848? NP_001349849? NP_001349850? XP_030105839? XP_030105844? XP_030105851? XP_030105854? XP_030105855? XP_030105857? XP_030105858? XP_030105859? XP_030105861? XP_030105862? XP_030105863? XP_030105864? XP_030105871? XP_030105872? XP_036016779? XP_036016780? XP_036016785? XP_036016792? XP_036016794 NP_001277554? NP_001277555? NP_796319? XP_006498038? XP_006498041? XP_006498043? XP_006498046? XP_011237385? XP_011237386? NP_001349848? NP_001349849? NP_001349850? XP_030105839? XP_030105844? XP_030105851? XP_030105854? XP_030105855? XP_030105857? XP_030105858? XP_030105859? XP_030105861? XP_030105862? XP_030105863? XP_030105864? XP_030105871? XP_030105872? XP_036016779? XP_036016780? XP_036016785? XP_036016792? XP_036016794
	?????????
??????/?????? ?????	??????/?????? ???

?????? ??? ?????? ?????????? ?? ??????? ???????????????????? ( ??????? : Target of rapamycin complex 2 subunit MAPKAP1 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ MAPKAP1 ≫ ???????? ??????. ^[?]^[?] ??? ??????? ???????? ?? mTORC2 ???.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000038696 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Schroder W, Cloonan N, Bushell G, Sculley T (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene . 339 : 17?23. doi : 10.1016/j.gene.2004.07.001 . PMID 15363842 .
↑ "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1" .

?????????????? ?????????. ≪ MAPKAP1 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ??????? ????.

???? ??????? ????? [ ?????? ]

Colicelli J; Nicolette C; Birchmeier C; et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae" . Proc. Natl. Acad. Sci. U.S.A . 88 (7): 2913?7. Bibcode : 1991PNAS...88.2913C . doi : 10.1073/pnas.88.7.2913 . PMC 51350 . PMID 1849280 .
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Jin J; Smith FD; Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol . 14 (16): 1436?50. doi : 10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 .
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal . 17 (6): 761?7. doi : 10.1016/j.cellsig.2004.10.015 . PMID 15722200 .
Benzinger A; Muster N; Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Mol. Cell. Proteomics . 4 (6): 785?95. doi : 10.1074/mcp.M500021-MCP200 . PMID 15778465 .
Cheng J; Zhang D; Kim K; et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation" . Mol. Cell. Biol . 25 (14): 5955?64. doi : 10.1128/MCB.25.14.5955-5964.2005 . PMC 1168836 . PMID 15988011 .
Venables JP; Bourgeois CF; Dalgliesh C; et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon" . Hum. Mol. Genet . 14 (16): 2289?303. doi : 10.1093/hmg/ddi233 . PMID 16000324 .
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173?8. Bibcode : 2005Natur.437.1173R . doi : 10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Frias MA; Thoreen CC; Jaffe JD; et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s" . Curr. Biol . 16 (18): 1865?70. doi : 10.1016/j.cub.2006.08.001 . PMID 16919458 . S2CID 8239162 .
Jacinto E; Facchinetti V; Liu D; et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity" . Cell . 127 (1): 125?37. doi : 10.1016/j.cell.2006.08.033 . PMID 16962653 . S2CID 230319 .
Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity" . Genes Dev . 20 (20): 2820?32. doi : 10.1101/gad.1461206 . PMC 1619946 . PMID 17043309 .
Makino C; Sano Y; Shinagawa T; et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells . 11 (11): 1239?51. doi : 10.1111/j.1365-2443.2006.01016.x . PMID 17054722 . S2CID 10605647 .
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635?48. doi : 10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Schroder WA; Buck M; Cloonan N; et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal . 19 (6): 1279?89. doi : 10.1016/j.cellsig.2007.01.013 . PMID 17303383 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000038696 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid15363842-4] Schroder W, Cloonan N, Bushell G, Sculley T (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene . 339 : 17?23. doi : 10.1016/j.gene.2004.07.001 . PMID 15363842 .

[entrez-5] "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1" .

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