MAP4K2

MAP4K2
?????????????
??????? ????	MAP4K2 , BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
????????? ??????	OMIM: 603166 MGI: 1346883 HomoloGene: 3370 GeneCards: MAP4K2
?????? ?? (???)
????????	???????? ?? (???)
?????	6,405,645 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? transferase activity ; ? nucleotide binding ; ? protein kinase activity ; ? mitogen-activated protein kinase kinase kinase binding ; ? kinase activity ; ? protein serine/threonine kinase activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? ATP binding ; ? MAP kinase kinase kinase kinase activity ;
??????? ?????	? ?????? ???? ; ? membrane ; ? Golgi membrane ; ? ????? ????? ; ? basolateral plasma membrane ; ? ????????? ;
?????? ?????	? GO:0007243 intracellular signal transduction ; ? vesicle targeting ; ? ???????? ; ? immune system process ; ? positive regulation of JNK cascade ; ? protein phosphorylation ; ? JNK cascade ; ? GO:0046730? GO:0046737? GO:0046738? GO:0046736 ???? ????? ; ? ?????? ????? ???? ; ? regulation of mitotic cell cycle ; ? regulation of apoptotic process ; ? GO:0072468 ???????? ???? ; ? stress-activated protein kinase signaling cascade ; ? activation of protein kinase activity ;
	?????: ????? / ????????
?????????????
	5871
	26412
	ENSG00000168067
	ENSMUSG00000024948
	Q12851
	Q61161
	NM_004579 NM_001307990? NM_004579
	NM_009006? NR_117093? XM_006531755? XM_006531756? XM_006531757? XM_006531760? XM_017318211? XM_017318212? XR_001782591? XM_036161600 NM_001291787? NM_009006? NR_117093? XM_006531755? XM_006531756? XM_006531757? XM_006531760? XM_017318211? XM_017318212? XR_001782591? XM_036161600
	NP_004570? XP_011543506? XP_016873582? XP_016873584? XP_024304397? XP_024304398? XP_024304399? XP_024304401? XP_024304402 NP_001294919? NP_004570? XP_011543506? XP_016873582? XP_016873584? XP_024304397? XP_024304398? XP_024304399? XP_024304401? XP_024304402
	NP_033032? XP_006531818? XP_006531819? XP_006531820? XP_006531823? XP_017173700? XP_017173701? XP_036017493 NP_001278716? NP_033032? XP_006531818? XP_006531819? XP_006531820? XP_006531823? XP_017173700? XP_017173701? XP_036017493
	?????????
??????/?????? ?????	??????/?????? ???

??????? ????? ????? ????? ????? ? ?????????? ???? ?????? ( ??????? : Mitogen-activated protein kinase kinase kinase kinase 2 ) ?? ????? ??? ?? ?? ????? ???? ?? ≪ MAP3K10 ≫ ???????? ??????. ^[?]^[?]

??? ??????? ?? RAB8A ^[?] ? TRAF2 ^[?] ????? ???????-??????? ????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024948 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry . 269 (24): 16802?9. PMID 7515885 .
↑ "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2" .
↑ Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase" . Proceedings of the National Academy of Sciences of the United States of America . 93 (10): 5151?5. doi : 10.1073/pnas.93.10.5151 . PMC 39423 . PMID 8643544 .
↑ Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry . 273 (35): 22681?92. doi : 10.1074/jbc.273.35.22681 . PMID 9712898 .

?????????????? ?????????. ≪ MAP4K2 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ???? ????.

???? ??????? ????? [ ?????? ]

Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P (Apr 1992). "Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus". Nature . 356 (6371): 721?2. doi : 10.1038/356721a0 . PMID 1570017 .
Matsutani A, Janssen R, Donis-Keller H, Permutt MA (Feb 1992). "A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p". Genomics . 12 (2): 319?25. doi : 10.1016/0888-7543(92)90380-B . PMID 1740341 .
Pombo CM, Kehrl JH, Sanchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM (Oct 1995). "Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase". Nature . 377 (6551): 750?4. doi : 10.1038/377750a0 . PMID 7477268 .
Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase" . Proceedings of the National Academy of Sciences of the United States of America . 93 (10): 5151?5. doi : 10.1073/pnas.93.10.5151 . PMC 39423 . PMID 8643544 .
Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (Jul 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus" . Genome Research . 7 (7): 725?35. doi : 10.1101/gr.7.7.725 . PMC 310681 . PMID 9253601 .
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry . 273 (35): 22681?92. doi : 10.1074/jbc.273.35.22681 . PMID 9712898 .
Chadee DN, Yuasa T, Kyriakis JM (Feb 2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2" . Molecular and Cellular Biology . 22 (3): 737?49. doi : 10.1128/MCB.22.3.737-749.2002 . PMC 133545 . PMID 11784851 .
Wissing J, Jansch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H (Mar 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics . 6 (3): 537?47. doi : 10.1074/mcp.T600062-MCP200 . PMID 17192257 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000024948 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid7515885-4] Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry . 269 (24): 16802?9. PMID 7515885 .

[entrez-5] "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2" .

[pmid8643544-6] Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase" . Proceedings of the National Academy of Sciences of the United States of America . 93 (10): 5151?5. doi : 10.1073/pnas.93.10.5151 . PMC 39423 . PMID 8643544 .

[pmid9712898-7] Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry . 273 (35): 22681?92. doi : 10.1074/jbc.273.35.22681 . PMID 9712898 .

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