MAP3K10

MAP3K10
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2RF0
?????????????
??????? ????	MAP3K10 , MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10
????????? ??????	OMIM: 600137 MGI: 1346879 HomoloGene: 1834 GeneCards: MAP3K10
?????? ?? (???)
????????	???????? ? (???)
?????	27,374,023 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? transferase activity ; ? protein kinase activity ; ? nucleotide binding ; ? protein homodimerization activity ; ? GO:0001106 transcription corepressor activity ; ? kinase activity ; ? protein serine/threonine kinase activity ; ? bHLH transcription factor binding ; ? ATP binding ; ? MAP kinase kinase kinase activity ; ? JUN kinase kinase kinase activity ;
??????? ?????	? ????????? ; ? intracellular anatomical structure ;
?????? ?????	? ???????? ; ? positive regulation of JUN kinase activity ; ? ??? ????? ; ? positive regulation of JNK cascade ; ? negative regulation of DNA-binding transcription factor activity ; ? protein phosphorylation ; ? JNK cascade ; ? GO:0035404 peptidyl-serine phosphorylation ; ? protein autophosphorylation ; ? ???? ?????????? ??????? ; ? peptidyl-threonine phosphorylation ; ? GO:0045996 negative regulation of transcription, DNA-templated ; ? GO:0072468 ???????? ???? ; ? GO:0097285 ??? ??????????????? ????? ; ? positive regulation of apoptotic process ; ? MAPK cascade ;
	?????: ????? / ????????
?????????????
	4294
	269881
	ENSG00000130758
	ENSMUSG00000040390
	Q02779
	Q66L42
	XM_011526981? XM_011526982? XM_047438844? XM_047438845 NM_002446? XM_011526981? XM_011526982? XM_047438844? XM_047438845
	NM_001290528? XM_017322287? XM_017322288? XM_017322289? XM_017322290? XR_001785564? XM_030242617? XM_030242618? XR_004934109? XR_004934110? XR_004934111? XR_004934112 NM_001081292? NM_001290528? XM_017322287? XM_017322288? XM_017322289? XM_017322290? XR_001785564? XM_030242617? XM_030242618? XR_004934109? XR_004934110? XR_004934111? XR_004934112
	XP_006723286? XP_011525283? XP_011525284? XP_024307287 NP_002437? XP_006723286? XP_011525283? XP_011525284? XP_024307287
	XP_017177776? XP_017177777? XP_017177778? XP_017177779? XP_030098477? XP_030098478 NP_001277457? XP_017177776? XP_017177777? XP_017177778? XP_017177779? XP_030098477? XP_030098478
	?????????
??????/?????? ?????	??????/?????? ???

??????? ????? ????? ????? ?? ?????????? ???? ?????? ( ??????? : Mitogen-activated protein kinase kinase kinase 10 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ MAP3K10 ≫ ???????? ??????. ^[?]^[?]^[?]

??? ??????? ?? ?????????? ????? ???????-??????? ????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000040390 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem . 234 (2): 492?500. doi : 10.1111/j.1432-1033.1995.492_b.x . PMID 8536694 .
↑ Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene . 10 (7): 1447?51. PMID 7731697 .
↑ "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10" .
↑ Liu YF, Dorow D, Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem . 275 (25): 19035?40. doi : 10.1074/jbc.C000180200 . PMID 10801775 .

?????????????? ?????????. ≪ MAP3K10 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ???? ????.

???? ??????? ????? [ ?????? ]

Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem . 269 (21): 15092?100. PMID 8195146 .
Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem . 213 (2): 701?10. doi : 10.1111/j.1432-1033.1993.tb17810.x . PMID 8477742 .
Hirai Si, Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S (1997). "MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem . 272 (24): 15167?73. doi : 10.1074/jbc.272.24.15167 . PMID 9182538 .
Hirai Si, Noda K, Moriguchi T, Nishida E, Yamashita A, Deyama T, Fukuyama K, Ohno S (1998). "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2". J. Biol. Chem . 273 (13): 7406?12. doi : 10.1074/jbc.273.13.7406 . PMID 9516438 .
Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis . 19 (5): 809?17. doi : 10.1002/elps.1150190535 . PMID 9629920 .
Rasmussen RK, Rusak J, Price G, Robinson PJ, Simpson RJ, Dorow DS (1998). "Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid" . Biochem. J . 335 (Pt 1): 119?24. doi : 10.1042/bj3350119 . PMC 1219759 . PMID 9742220 .
Liu YF, Dorow D, Marshall J (2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem . 275 (25): 19035?40. doi : 10.1074/jbc.C000180200 . PMID 10801775 .
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788?95. doi : 10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Savinainen A, Garcia EP, Dorow D, Marshall J, Liu YF (2001). "Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95". J. Biol. Chem . 276 (14): 11382?6. doi : 10.1074/jbc.M100190200 . PMID 11152698 .
Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA (2001). "The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis" . Mol. Cell. Biol . 21 (14): 4713?24. doi : 10.1128/MCB.21.14.4713-4724.2001 . PMC 87148 . PMID 11416147 .
Poy MN, Yang Y, Rezaei K, Fernstrom MA, Lee AD, Kido Y, Erickson SK, Najjar SM (2002). "CEACAM1 regulates insulin clearance in liver". Nat. Genet . 30 (3): 270?6. doi : 10.1038/ng840 . PMID 11850617 .
Akbarzadeh S, Ji H, Frecklington D, Marmy-Conus N, Mok YF, Bowes L, Devereux L, Linsenmeyer M, Simpson RJ, Dorow DS (2002). "Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking". J. Biol. Chem . 277 (39): 36280?7. doi : 10.1074/jbc.M204626200 . PMID 12105200 .
Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem . 278 (48): 47922?7. doi : 10.1074/jbc.M307357200 . PMID 14504284 .
Eckey M, Tenbaum SP, Munoz A, Baniahmad A (2004). "Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors". Mol. Cell. Endocrinol . 213 (1): 71?8. doi : 10.1016/j.mce.2003.10.035 . PMID 15062575 .
Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol . 15 (5): 405?12. doi : 10.1016/j.cub.2004.12.082 . PMID 15753034 .
Kollers S, Musilova P, Rubes J, Rocha D (2007). "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13". Anim. Genet . 37 (6): 595?6. doi : 10.1111/j.1365-2052.2006.01516.x . PMID 17121608 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000040390 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid8536694-4] Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem . 234 (2): 492?500. doi : 10.1111/j.1432-1033.1995.492_b.x . PMID 8536694 .

[pmid7731697-5] Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene . 10 (7): 1447?51. PMID 7731697 .

[entrez-6] "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10" .

[pmid10801775-7] Liu YF, Dorow D, Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem . 275 (25): 19035?40. doi : 10.1074/jbc.C000180200 . PMID 10801775 .

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