MAFB

MAFB
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2WT7 , 2WTY , 4AUW
?????????????
??????? ????	MAFB , KRML, MCTO, MAF bZIP transcription factor B, DURS3
????????? ??????	OMIM: 608968 MGI: 104555 HomoloGene: 31315 GeneCards: MAFB
?????? ?? (???)
????????	???????? ? (???)
?????	160,208,985 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? DNA binding ; ? GO:0001131? GO:0001151? GO:0001130? GO:0001204 DNA-binding transcription factor activity ; ? GO:0001077? GO:0001212? GO:0001213? GO:0001211? GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; ? transcription factor binding ; ? GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? protein homodimerization activity ; ? protein heterodimerization activity ; ? sequence-specific double-stranded DNA binding ; ? GO:0001200? GO:0001133? GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ; ? sequence-specific DNA binding ;
??????? ?????	? transcription regulator complex ; ? ???? ????? ;
?????? ?????	? T cell differentiation in thymus ; ? negative regulation of osteoclast differentiation ; ? brain segmentation ; ? thymus development ; ? transcription by RNA polymerase II ; ? respiratory gaseous exchange by respiratory system ; ? segment specification ; ? negative regulation of erythrocyte differentiation ; ? ?????????? ?????? ???? ????? ; ? transcription, DNA-templated ; ? rhombomere 6 development ; ? rhombomere 5 development ; ? inner ear morphogenesis ; ? sensory organ development ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? GO:0009373 regulation of transcription, DNA-templated ; ? abducens nerve formation ; ? GO:0044324? GO:0003256? GO:1901213? GO:0046019? GO:0046020? GO:1900094? GO:0061216? GO:0060994? GO:1902064? GO:0003258? GO:0072212 regulation of transcription by RNA polymerase II ;
	?????: ????? / ????????
?????????????
	9935
	16658
	ENSG00000204103
	ENSMUSG00000074622
	Q9Y5Q3
	P54841
	NM_005461
	NM_010658
	NP_005452
	NP_034788
	?????????
??????/?????? ?????	??????/?????? ???

?????? ??????? MAFB ( ??????? : Transcription factor MafB ) ?? ?? ???? ??????? B ?????? ????????????????? ????????????? V-maf ?? ?????? ??????? ?? ??????? ??? ?? ?? ?????? ???? ?? ≪ MAFB ≫ ??????? ??????. ??? ?? ?? ??? ????? ???? ???????? ?? ???? ???? ? ?? ?? ????? ?? ?????? 3kb ????? ???????. ^[?]^[?]

?????? ?? ???????? ??-????????? (SNPs) ?? ?????? ??? ?? ?? ?? ???? ??? ? ??????? ???? ?????? ????? ???? ??? ???????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000074622 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Wang PW, Eisenbart JD, Cordes SP, Barsh GS, Stoffel M, Le Beau MM (Aug 1999). "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics . 59 (3): 275?81. doi : 10.1006/geno.1999.5884 . PMID 10444328 .
↑ "Entrez Gene: MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)" .
↑ Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Scott JM, Arcos-Burgos M, Scott AF (Jun 2010). "A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4" . Nature Genetics . 42 (6): 525?9. doi : 10.1038/ng.580 . PMC 2941216 . PMID 20436469 .

?????????????? ?????????. ≪ MAFB (gene) ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ???? ????.

????? ??????? [ ?????? ]

Cordes SP, Barsh GS (Dec 1994). "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell . 79 (6): 1025?34. doi : 10.1016/0092-8674(94)90033-7 . PMID 8001130 .
Sieweke MH, Tekotte H, Frampton J, Graf T (Apr 1996). "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation". Cell . 85 (1): 49?60. doi : 10.1016/S0092-8674(00)81081-8 . PMID 8620536 .
Stoffel M, Le Beau MM, Espinosa R, Bohlander SF, Le Paslier D, Cohen D, Xiang KS, Cox NJ, Fajans SS, Bell GI (Apr 1996). "A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene" . Proceedings of the National Academy of Sciences of the United States of America . 93 (9): 3937?41. doi : 10.1073/pnas.93.9.3937 . PMC 39463 . PMID 8632993 .
Li R, Pei H, Watson DK, Papas TS (Feb 2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes". Oncogene . 19 (6): 745?53. doi : 10.1038/sj.onc.1203385 . PMID 10698492 .
Yamada K, Tomita H, Yoshiura K, Kondo S, Wakui K, Fukushima Y, Ikegawa S, Nakamura Y, Amemiya T, Niikawa N (Jul 2000). "An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12". European Journal of Human Genetics . 8 (7): 535?9. doi : 10.1038/sj.ejhg.5200485 . PMID 10909854 .
Rosenberger G, Jantke I, Gal A, Kutsche K (Jan 2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Human Molecular Genetics . 12 (2): 155?67. doi : 10.1093/hmg/ddg019 . PMID 12499396 .
Hashizume H, Hamalainen H, Sun Q, Sucharczuk A, Lahesmaa R (Jan 2003). "Downregulation of mafB expression in T-helper cells during early differentiation in vitro". Scandinavian Journal of Immunology . 57 (1): 28?34. doi : 10.1046/j.1365-3083.2003.01181.x . PMID 12542795 .
Fernandez-Calotti PX, Salamone G, Gamberale R, Trevani A, Vermeulen M, Geffner J, Giordano M (Jan 2003). "Downregulation of mac-1 expression in monocytes by surface-bound IgG". Scandinavian Journal of Immunology . 57 (1): 35?44. doi : 10.1046/j.1365-3083.2003.01187.x . PMID 12542796 .
Mechta-Grigoriou F, Giudicelli F, Pujades C, Charnay P, Yaniv M (Jun 2003). "c-jun regulation and function in the developing hindbrain". Developmental Biology . 258 (2): 419?31. doi : 10.1016/S0012-1606(03)00135-0 . PMID 12798298 .
Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL (May 2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression". Nature Genetics . 36 (5): 462?70. doi : 10.1038/ng1352 . PMID 15107855 .
Sevinsky JR, Whalen AM, Ahn NG (May 2004). "Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler" . Molecular and Cellular Biology . 24 (10): 4534?45. doi : 10.1128/MCB.24.10.4534-4545.2004 . PMC 400447 . PMID 15121870 .
Petersen HH, Hilpert J, Jacobsen C, Lauwers A, Roebroek AJ, Willnow TE (May 2004). "Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development". FEBS Letters . 565 (1?3): 23?7. doi : 10.1016/j.febslet.2004.03.069 . PMID 15135046 .
Bakri Y, Sarrazin S, Mayer UP, Tillmanns S, Nerlov C, Boned A, Sieweke MH (Apr 2005). "Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate". Blood . 105 (7): 2707?16. doi : 10.1182/blood-2004-04-1448 . PMID 15598817 .
Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S (Oct 2006). "Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells". Cell Death and Differentiation . 13 (10): 1686?96. doi : 10.1038/sj.cdd.4401860 . PMID 16456583 .
Lee LC, Zhang AY, Chong AK, Pham H, Longaker MT, Chang J (Feb 2006). "Expression of a novel gene, MafB, in Dupuytren's disease" . The Journal of Hand Surgery . 31 (2): 211?8. doi : 10.1016/j.jhsa.2005.09.007 . PMID 16473681 .

????? ?? ????? [ ?????? ]

MAFB protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????
???? ?? ?????? MAFB ?? ?????? ????? UCSC.
?????? ?? ?????? MAFB ?? ?????? ????? UCSC.

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000074622 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10444328-4] Wang PW, Eisenbart JD, Cordes SP, Barsh GS, Stoffel M, Le Beau MM (Aug 1999). "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics . 59 (3): 275?81. doi : 10.1006/geno.1999.5884 . PMID 10444328 .

[entrez-5] "Entrez Gene: MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)" .

[pmid20436469-6] Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Scott JM, Arcos-Burgos M, Scott AF (Jun 2010). "A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4" . Nature Genetics . 42 (6): 525?9. doi : 10.1038/ng.580 . PMC 2941216 . PMID 20436469 .

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