KLF8

KLF8
?????????????
??????? ????	KLF8 , BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
????????? ??????	OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
?????? ?? (?????)
????????	???????? X (?????)
?????	56,291,531 bp
?????? ?? (???)
????????	???????? X (???)
?????	152,179,128 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? DNA binding ; ? metal ion binding ; ? nucleic acid binding ; ? GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; ? GO:0001078? GO:0001214? GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific ; ? GO:0001200? GO:0001133? GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
??????? ?????	? ???? ????? ; ? ??????????? ; ? ??????? ; ? aggresome ;
?????? ?????	? GO:0009373 regulation of transcription, DNA-templated ; ? transcription, DNA-templated ; ? GO:1901227 negative regulation of transcription by RNA polymerase II ; ? GO:0044324? GO:0003256? GO:1901213? GO:0046019? GO:0046020? GO:1900094? GO:0061216? GO:0060994? GO:1902064? GO:0003258? GO:0072212 regulation of transcription by RNA polymerase II ;
	?????: ????? / ????????
?????????????
	11279
	245671
	ENSG00000102349
	ENSMUSG00000041649
	O95600
	Q8BLM0
	NM_007250? XM_006724575? NM_001324099? NM_001324100? NM_001324102? NM_001324104? NM_001324105? NR_136704? NR_136705? XM_017029250? XM_024452332? XM_047441795? XM_047441796? XM_047441797? XM_047441798? XM_047441799? XM_047441800 NM_001159296? NM_007250? XM_006724575? NM_001324099? NM_001324100? NM_001324102? NM_001324104? NM_001324105? NR_136704? NR_136705? XM_017029250? XM_024452332? XM_047441795? XM_047441796? XM_047441797? XM_047441798? XM_047441799? XM_047441800
	XM_006528852? XM_006528859? XM_006528860? XM_011247821? XM_017318503? XM_017318505? XM_017318506? NM_001357183? XM_030251350? XM_030251351? XM_036161970 NM_173780? XM_006528852? XM_006528859? XM_006528860? XM_011247821? XM_017318503? XM_017318505? XM_017318506? NM_001357183? XM_030251350? XM_030251351? XM_036161970
	NP_001311028? NP_001311029? NP_001311031? NP_001311033? NP_001311034? NP_009181? XP_005262034? XP_006724638? XP_011529061? XP_016884739? XP_024308100 NP_001152768? NP_001311028? NP_001311029? NP_001311031? NP_001311033? NP_001311034? NP_009181? XP_005262034? XP_006724638? XP_011529061? XP_016884739? XP_024308100
	XP_006528915? XP_006528922? XP_006528923? XP_011246123? XP_017173992? XP_017173994? XP_017173995? NP_001344112? XP_030107210? XP_030107211? XP_036017863 NP_776141? XP_006528915? XP_006528922? XP_006528923? XP_011246123? XP_017173992? XP_017173994? XP_017173995? NP_001344112? XP_030107210? XP_030107211? XP_036017863
	?????????
??????/?????? ?????	??????/?????? ???

?????? ??? ????? ? ( ??????? : Krueppel-like factor 8 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ KLF8 ≫ ???????? ??????. ^[?]

??? ??????? ????? ?? ???????? ???????? KLF ??? ?? ???? ???? ?????? KLF1 ? KLF3 ???? ??????? ??? KLF3 ?????????? ???? ???? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl , May 2017
↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Entrez Gene: KLF8 Kruppel-like factor 8" .
↑ Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing" . asm.org . Archived from the original on 15 December 2018 . Retrieved 12 January 2019 . {{ cite web }}: Explicit use of et al. in: |author= ( help )

?????????????? ?????????. ≪ KLF8 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ????? ????.

????? ?? ????? [ ?????? ]

KLF8 protein, human ?? ??????????? ?????? ????? (MeSH) ?? ????????? ??? ????? ?????? ?????? ??????

???? ??????? ????? [ ?????? ]

van Vliet J, Turner J, Crossley M (May 2000). "Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription" . Nucleic Acids Research . 28 (9): 1955?62. doi : 10.1093/nar/28.9.1955 . PMC 103308 . PMID 10756197 .
Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation" . Journal of Medical Genetics . 39 (2): 113?7. doi : 10.1136/jmg.39.2.113 . PMC 1735036 . PMID 11836360 .
Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Kruppel-like factor/Kruppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry . 278 (15): 12786?95. doi : 10.1074/jbc.M300587200 . PMID 12556451 .
Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell . 11 (6): 1503?15. doi : 10.1016/S1097-2765(03)00179-5 . PMID 12820964 .
Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Kruppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases . 35 (2): 227?35. doi : 10.1016/j.bcmd.2005.04.009 . PMID 16023392 .
Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene . 26 (3): 456?61. doi : 10.1038/sj.onc.1209796 . PMID 16832343 .
Hu JH, Navas P, Cao H, Stamatoyannopoulos G , Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation" . Journal of Molecular Biology . 366 (4): 1064?73. doi : 10.1016/j.jmb.2006.12.047 . PMC 1907364 . PMID 17224162 .
Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research . 67 (15): 7184?93. doi : 10.1158/0008-5472.CAN-06-4729 . PMID 17671186 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCh38Ensembl-1] ??? ^??? ^??? GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl , May 2017

[refGRCm38Ensembl-2] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl , May 2017

[3] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[entrez-5] "Entrez Gene: KLF8 Kruppel-like factor 8" .

[molecular_and_cell_biology-6] Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing" . asm.org . Archived from the original on 15 December 2018 . Retrieved 12 January 2019 . {{ cite web }}: Explicit use of et al. in: |author= ( help )

[?]

[?]

[?]

[?]

[?]

[?]