FZD8

FZD8
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	1IJY , 4F0A
?????????????
??????? ????	FZD8 , FZ-8, hFZ8, frizzled class receptor 8
????????? ??????	OMIM: 606146 MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
?????? ?? (???)
????????	???????? ?? (???)
?????	9,218,136 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? transmembrane signaling receptor activity ; ? signaling receptor binding ; ? ubiquitin protein ligase binding ; ? GO:0001948? GO:0016582 ????? ???????? ; ? signal transducer activity ; ? PDZ domain binding ; ? G protein-coupled receptor activity ; ? Wnt-protein binding ; ? Wnt-activated receptor activity ;
??????? ?????	? integral component of membrane ; ? membrane ; ? ????? ????? ; ? ?????? ???? ; ? Wnt-Frizzled-LRP5/6 complex ;
?????? ?????	? positive regulation of protein phosphorylation ; ? positive regulation of JUN kinase activity ; ? cell surface receptor signaling pathway ; ? G protein-coupled receptor signaling pathway ; ? ??????? ; ? GO:0003257? GO:0010735? GO:1901228? GO:1900622? GO:1904488 positive regulation of transcription by RNA polymerase II ; ? multicellular organism development ; ? GO:1901227 negative regulation of transcription by RNA polymerase II ; ? neuron differentiation ; ? GO:0072468 ???????? ???? ; ? Wnt signaling pathway ; ? T cell differentiation in thymus ; ? non-canonical Wnt signaling pathway ; ? canonical Wnt signaling pathway ;
	?????: ????? / ????????
?????????????
	8325
	14370
	ENSG00000177283
	ENSMUSG00000036904
	Q9H461
	Q61091
	NM_031866
	NM_008058
	NP_114072
	NP_032084
	?????????
??????/?????? ?????	??????/?????? ???

?????? ? ( ??????? : Frizzled-8 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ FZD8 ≫ ??????? ??????. ^[?]^[?]

????? ???????? ?????? ??????? ?? ?????? ????????? ?? ??????? ?? ?? ??? ????? ???????? ???????? ?? ?? ??????? ?? ???? ??????????? ???? ????????? Wnt ?????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000036904 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol . 18 (5): 991?6. doi : 10.3892/ijo.18.5.991 . PMID 11295046 .
↑ "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)" .

?????????????? ?????????. ≪ FZD8 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem . 271 (8): 4468?4476. doi : 10.1074/jbc.271.8.4468 . PMID 8626800 .
Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action" . Proc. Natl. Acad. Sci. U.S.A . 94 (13): 6770?6775. doi : 10.1073/pnas.94.13.6770 . PMC 21233 . PMID 9192640 .
Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature . 407 (6803): 530?535. doi : 10.1038/35035117 . PMID 11029007 .
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788?1795. doi : 10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol . 11 (12): 951?961. doi : 10.1016/S0960-9822(01)00290-1 . PMID 11448771 .
Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature . 412 (6842): 86?90. doi : 10.1038/35083601 . PMID 11452312 .
Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun . 286 (4): 771?778. doi : 10.1006/bbrc.2001.5430 . PMID 11520064 .
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet . 25 (2): 81?90. doi : 10.1080/13816810490514270 . PMID 15370539 .
Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell . 119 (1): 97?108. doi : 10.1016/j.cell.2004.09.019 . PMID 15454084 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000036904 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid11295046-4] Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol . 18 (5): 991?6. doi : 10.3892/ijo.18.5.991 . PMID 11295046 .

[entrez-5] "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)" .

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