FZD4

FZD4
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	5BPB , 5BPQ , 5BQC , 5BQE , 5CL1 , 5CM4
?????????????
??????? ????	FZD4 , CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4, frizzled class receptor 4
????????? ??????	OMIM: 604579 MGI: 108520 HomoloGene: 7325 GeneCards: FZD4
?????? ?? (???)
????????	???????? ? (???)
?????	89,062,342 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? PDZ domain binding ; ? protein homodimerization activity ; ? signal transducer activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? protein heterodimerization activity ; ? Wnt-activated receptor activity ; ? ubiquitin protein ligase binding ; ? transmembrane signaling receptor activity ; ? GO:0019974 cytokine binding ; ? G protein-coupled receptor activity ; ? Wnt-protein binding ; ? amyloid-beta binding ; ? signaling receptor activity ; ? GO:0032403 protein-containing complex binding ;
??????? ?????	? clathrin-coated endocytic vesicle membrane ; ? membrane ; ? cell-cell junction ; ? ????? ????? ; ? integral component of plasma membrane ; ? cell surface ; ? extracellular exosome ; ? integral component of membrane ; ? clathrin-coated vesicle membrane ; ? ?????? ; ? ?????? ; ? glutamatergic synapse ;
?????? ?????	? negative regulation of cell-substrate adhesion ; ? cellular response to retinoic acid ; ? G protein-coupled receptor signaling pathway ; ? luteinization ; ? extracellular matrix-cell signaling ; ? positive regulation of JUN kinase activity ; ? positive regulation of DNA-binding transcription factor activity ; ? ?????? ; ? Wnt signaling pathway ; ? regulation of vascular endothelial growth factor receptor signaling pathway ; ? vasculogenesis ; ? GO:0060469? GO:0009371 positive regulation of transcription, DNA-templated ; ? multicellular organism development ; ? cerebellum vasculature morphogenesis ; ? cell surface receptor signaling pathway ; ? progesterone secretion ; ? blood vessel development ; ? neuron differentiation ; ? retinal blood vessel morphogenesis ; ? canonical Wnt signaling pathway ; ? substrate adhesion-dependent cell spreading ; ? locomotion involved in locomotory behavior ; ? retina vasculature morphogenesis in camera-type eye ; ? GO:0072468 ???????? ???? ; ? Wnt signaling pathway, calcium modulating pathway ; ? Wnt signaling pathway, planar cell polarity pathway ; ? membrane organization ; ? non-canonical Wnt signaling pathway ; ? positive regulation of neuron projection arborization ; ? cellular response to leukemia inhibitory factor ;
	?????: ????? / ????????
?????????????
	8322
	14366
	ENSG00000174804
	ENSMUSG00000049791
	Q9ULV1
	Q61088
	NM_012193
	XM_036152680 NM_008055? XM_036152680
	NP_036325
	XP_036008573 NP_032081? XP_036008573
	?????????
??????/?????? ?????	??????/?????? ???

?????? ? ( ??????? : Frizzled-4 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ FZD4 ≫ ??????? ??????. ^[?]^[?]^[?] ??? ??????? ?? ??? CD344 ?? ?????? ??????.

????? ???????? ?????? ??????? ?? ?????? ????????? ?? ??????? ?? ?? ??? ????? ???????? ???????? ?? ?? ??????? ?? ???? ??????????? ???? ????????? Wnt ?????.

??? ??????? ????? ??????? ?? ????? ?????? ?????? ? ?? ????? ? ??? ???? ?? ????? ??? ? ?????? ??????? ?????????? ??? ????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000049791 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Nov 1999). "Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21". Biochemical and Biophysical Research Communications . 264 (3): 955?61. doi : 10.1006/bbrc.1999.1612 . PMID 10544037 .
↑ Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Apr 2004). "Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q" . American Journal of Human Genetics . 74 (4): 721?30. doi : 10.1086/383202 . PMC 1181948 . PMID 15024691 .
↑ "Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)" .

?????????????? ?????????. ≪ FZD4 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Li Y, Fuhrmann C, Schwinger E, Gal A, Laqua H (Jun 1992). "The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11". American Journal of Ophthalmology . 113 (6): 712?3. doi : 10.1016/s0002-9394(14)74800-7 . PMID 1598965 .
Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals" . Proceedings of the National Academy of Sciences of the United States of America . 95 (17): 10164?9. doi : 10.1073/pnas.95.17.10164 . PMC 21479 . PMID 9707618 .
Sagara N, Kirikoshi H, Terasaki H, Yasuhiko Y, Toda G, Shiokawa K, Katoh M (Apr 2001). "FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway". Biochemical and Biophysical Research Communications . 282 (3): 750?6. doi : 10.1006/bbrc.2001.4634 . PMID 11401527 .
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters . 520 (1?3): 97?101. doi : 10.1016/S0014-5793(02)02775-8 . PMID 12044878 .
Hering H, Sheng M (Jun 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters . 521 (1?3): 185?9. doi : 10.1016/S0014-5793(02)02831-4 . PMID 12067714 .
Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dube MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME (Oct 2002). "Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy". Nature Genetics . 32 (2): 326?30. doi : 10.1038/ng957 . PMID 12172548 .
Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ (Sep 2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science . 301 (5638): 1391?4. doi : 10.1126/science.1082808 . PMID 12958364 .
Toomes C, Downey LM, Bottomley HM, Scott S, Woodruff G, Trembath RC, Inglehearn CF (Jan 2004). "Identification of a fourth locus (EVR4) for familial exudative vitreoretinopathy (FEVR)". Molecular Vision . 10 : 37?42. PMID 14737064 .
Yao R, Natsume Y, Noda T (Aug 2004). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene . 23 (36): 6023?30. doi : 10.1038/sj.onc.1207817 . PMID 15195140 .
Toomes C, Bottomley HM, Scott S, Mackey DA, Craig JE, Appukuttan B, Stout JT, Flaxel CJ, Zhang K, Black GC, Fryer A, Downey LM, Inglehearn CF (Jul 2004). "Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy" . Investigative Ophthalmology & Visual Science . 45 (7): 2083?90. doi : 10.1167/iovs.03-1044 . PMID 15223780 .
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics . 25 (2): 81?90. doi : 10.1080/13816810490514270 . PMID 15370539 .
Yoshida S, Arita R, Yoshida A, Tada H, Emori A, Noda Y, Nakao S, Fujisawa K, Ishibashi T (Oct 2004). "Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy" . American Journal of Ophthalmology . 138 (4): 670?1. doi : 10.1016/j.ajo.2004.05.001 . PMID 15488808 .
Qin M, Hayashi H, Oshima K, Tahira T, Hayashi K, Kondo H (Aug 2005). "Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes". Human Mutation . 26 (2): 104?12. doi : 10.1002/humu.20191 . PMID 15981244 .
Nallathambi J, Shukla D, Rajendran A, Namperumalsamy P, Muthulakshmi R, Sundaresan P (2006). "Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy". Molecular Vision . 12 : 1086?92. PMID 17093393 .
Planutis K, Planutiene M, Moyer MP, Nguyen AV, Perez CA, Holcombe RF (2007). "Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells" . BMC Cell Biology . 8 : 12. doi : 10.1186/1471-2121-8-12 . PMC 1847812 . PMID 17386109 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000049791 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10544037-4] Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Nov 1999). "Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21". Biochemical and Biophysical Research Communications . 264 (3): 955?61. doi : 10.1006/bbrc.1999.1612 . PMID 10544037 .

[pmid15024691-5] Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Apr 2004). "Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q" . American Journal of Human Genetics . 74 (4): 721?30. doi : 10.1086/383202 . PMC 1181948 . PMID 15024691 .

[entrez-6] "Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)" .

[?]

[?]

[?]

[?]

[?]

[?]