FZD2

FZD2
?????????????
??????? ????	FZD2 , Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
????????? ??????	OMIM: 600667 MGI: 1888513 HomoloGene: 20377 GeneCards: FZD2
?????? ?? (???)
????????	???????? ?? (???)
?????	102,498,884 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? PDZ domain binding ; ? signal transducer activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? transmembrane signaling receptor activity ; ? G protein-coupled receptor activity ; ? Wnt-protein binding ; ? Wnt-activated receptor activity ;
??????? ?????	? ????????? ; ? clathrin-coated endocytic vesicle membrane ; ? membrane ; ? focal adhesion ; ? ????? ????? ; ? integral component of membrane ;
?????? ?????	? G protein-coupled receptor signaling pathway ; ? epithelial cell differentiation ; ? muscular septum morphogenesis ; ? ventricular septum morphogenesis ; ? cell-cell signaling ; ? membranous septum morphogenesis ; ? outflow tract morphogenesis ; ? positive regulation of DNA-binding transcription factor activity ; ? Wnt signaling pathway ; ? planar cell polarity pathway involved in neural tube closure ; ? GO:0060469? GO:0009371 positive regulation of transcription, DNA-templated ; ? multicellular organism development ; ? sensory perception of smell ; ? cell surface receptor signaling pathway ; ? inner ear receptor cell development ; ? hard palate development ; ? cochlea morphogenesis ; ? neuron differentiation ; ? canonical Wnt signaling pathway ; ? GO:0072468 ???????? ???? ; ? beta-catenin destruction complex disassembly ; ? Wnt signaling pathway, calcium modulating pathway ; ? Wnt signaling pathway, planar cell polarity pathway ; ? non-canonical Wnt signaling pathway ; ? positive regulation of G protein-coupled receptor signaling pathway ;
	?????: ????? / ????????
?????????????
	2535
	57265
	ENSG00000180340
	ENSMUSG00000050288
	Q14332
	Q9JIP6
	NM_001466
	NM_020510
	NP_001457
	NP_065256
	?????????
??????/?????? ?????	??????/?????? ???

?????? ? ( ??????? : Frizzled-2 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ FZD2 ≫ ??????? ??????. ^[?]^[?]^[?]

????? ???????? ?????? ??????? ?? ?????? ????????? ?? ??????? ?? ?? ??? ????? ???????? ???????? ?? ?? ??????? ?? ???? ??????????? ???? ????????? Wnt ?????.

????????? ??????? ?? ??? ????? ?????? ???? ?? ???????? ???????? ?? ??? ???? ??????: ?? ????? ????? ?? ???? ? ??? ? ?? ????? ???? ?? ????? ???? ? ?????? . ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000050288 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics . 27 (2): 370?3. doi : 10.1006/geno.1995.1060 . PMID 7558010 .
↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun . 252 (1): 117?22. doi : 10.1006/bbrc.1998.9607 . PMID 9813155 .
↑ ^??? ^??? "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)" .

?????????????? ?????????. ≪ FZD2 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem . 271 (8): 4468?76. doi : 10.1074/jbc.271.8.4468 . PMID 8626800 .
Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action" . Proc. Natl. Acad. Sci. U.S.A . 94 (13): 6770?5. doi : 10.1073/pnas.94.13.6770 . PMC 21233 . PMID 9192640 .
Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals" . Proc. Natl. Acad. Sci. U.S.A . 95 (17): 10164?9. doi : 10.1073/pnas.95.17.10164 . PMC 21479 . PMID 9707618 .
Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett . 521 (1?3): 185?9. doi : 10.1016/S0014-5793(02)02831-4 . PMID 12067714 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells . 8 (7): 645?54. doi : 10.1046/j.1365-2443.2003.00662.x . PMID 12839624 .
Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet . 25 (2): 81?90. doi : 10.1080/13816810490514270 . PMID 15370539 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000050288 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid7558010-4] Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics . 27 (2): 370?3. doi : 10.1006/geno.1995.1060 . PMID 7558010 .

[pmid9813155-5] Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun . 252 (1): 117?22. doi : 10.1006/bbrc.1998.9607 . PMID 9813155 .

[entrez-6] ??? ^??? "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)" .

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