EPN1

EPN1
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	1INZ
?????????????
??????? ????	EPN1 , epsin 1
????????? ??????	OMIM: 607262 MGI: 1333763 HomoloGene: 32172 GeneCards: EPN1
?????? ?? (???)
????????	???????? ? (???)
?????	5,098,178 bp
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? lipid binding ;
??????? ?????	? ????????? ; ? ????? ????? ; ? clathrin-coated pit ; ? membrane ; ? ???? ????? ; ? ??????? ;
?????? ?????	? Notch signaling pathway ; ? female pregnancy ; ? negative regulation of epidermal growth factor receptor signaling pathway ; ? in utero embryonic development ; ? ????????? ; ? embryonic organ development ; ? membrane organization ; ? negative regulation of sprouting angiogenesis ;
	?????: ????? / ????????
?????????????
	29924
	13854
	ENSG00000063245
	ENSMUSG00000035203
	Q9Y6I3
	Q80VP1
	NM_001130072? NM_013333? NM_001321263 NM_001130071? NM_001130072? NM_013333? NM_001321263
	NM_010147? XM_006539529? XM_006539531? XM_006539532? XM_006539533? XM_006539534? XM_006539535? XM_006539536? XM_006539537? XM_006539538? XM_017321973? XM_017321974 NM_001252454? NM_010147? XM_006539529? XM_006539531? XM_006539532? XM_006539533? XM_006539534? XM_006539535? XM_006539536? XM_006539537? XM_006539538? XM_017321973? XM_017321974
	NP_001123544? NP_001308192? NP_037465 NP_001123543? NP_001123544? NP_001308192? NP_037465
	NP_034277? XP_006539592? XP_006539594? XP_006539595? XP_006539597? XP_006539598? XP_006539599? XP_006539600? XP_017177462? XP_017177463? XP_030097956? XP_030097957? XP_030097958? XP_030097959? XP_030097960? XP_030097962? XP_030097963? XP_030097964? XP_030097965? XP_030097966? XP_030097967? XP_030097968? XP_030097969? XP_030097970? XP_030097971? XP_030097973? XP_030097974? XP_030097975? XP_030097976? XP_030097977? XP_030097978? XP_030097979? XP_030097982? XP_030097983? XP_030097984? XP_030097985? XP_030097986? XP_030097987? NP_001359429? XP_036008550? XP_036008551? XP_036008552? XP_036008553? XP_036008554? XP_036008555? XP_036008556? XP_036008557? XP_036008558? XP_036008559 NP_001239383? NP_034277? XP_006539592? XP_006539594? XP_006539595? XP_006539597? XP_006539598? XP_006539599? XP_006539600? XP_017177462? XP_017177463? XP_030097956? XP_030097957? XP_030097958? XP_030097959? XP_030097960? XP_030097962? XP_030097963? XP_030097964? XP_030097965? XP_030097966? XP_030097967? XP_030097968? XP_030097969? XP_030097970? XP_030097971? XP_030097973? XP_030097974? XP_030097975? XP_030097976? XP_030097977? XP_030097978? XP_030097979? XP_030097982? XP_030097983? XP_030097984? XP_030097985? XP_030097986? XP_030097987? NP_001359429? XP_036008550? XP_036008551? XP_036008552? XP_036008553? XP_036008554? XP_036008555? XP_036008556? XP_036008557? XP_036008558? XP_036008559
	?????????
??????/?????? ?????	??????/?????? ???

????? ? ( ??????? : Epsin-1 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ EPN1 ≫ ???????? ??????. ^[?]^[?]^[?]

??? ??????? ?? AP2A2 ????? ???????-??????? ????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000035203 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ ^??? ^??? Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793?7. doi : 10.1038/29555 . PMID 9723620 .
↑ Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene . 18 (43): 5915?22. doi : 10.1038/sj.onc.1202974 . PMID 10557078 .
↑ "Entrez Gene: EPN1 epsin 1" .

?????????????? ?????????. ≪ EPN1 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ???? ????.

???? ??????? ????? [ ?????? ]

Drake MT, Downs MA, Traub LM (2000). "Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites". J. Biol. Chem . 275 (9): 6479?89. doi : 10.1074/jbc.275.9.6479 . PMID 10692452 .
Kariya K; Koyama S; Nakashima S; et al. (2000). "Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation". J. Biol. Chem . 275 (24): 18399?406. doi : 10.1074/jbc.M000521200 . PMID 10764745 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Hyman J; Chen H; Di Fiore PP; et al. (2000). "Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)" . J. Cell Biol . 149 (3): 537?46. doi : 10.1083/jcb.149.3.537 . PMC 2174850 . PMID 10791968 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Drake MT, Traub LM (2001). "Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller". J. Biol. Chem . 276 (31): 28700?9. doi : 10.1074/jbc.M104226200 . PMID 11382783 .
Ford MG; Mills IG; Peter BJ; et al. (2002). "Curvature of clathrin-coated pits driven by epsin". Nature . 419 (6905): 361?6. doi : 10.1038/nature01020 . PMID 12353027 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Koshiba S, Kigawa T, Kikuchi A, Yokoyama S (2003). "Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin". J. Struct. Funct. Genomics . 2 (1): 1?8. doi : 10.1023/A:1011397007366 . PMID 12836669 .
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40?5. doi : 10.1038/ng1285 . PMID 14702039 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Timsit YE, Miller SL, Mohney RP, O'Bryan JP (2005). "The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin". Biochem. Biophys. Res. Commun . 328 (2): 550?9. doi : 10.1016/j.bbrc.2005.01.022 . PMID 15694383 .
Schmid EM; Ford MG; Burtey A; et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly" . PLoS Biol . 4 (9): e262. doi : 10.1371/journal.pbio.0040262 . PMC 1540706 . PMID 16903783 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635?48. doi : 10.1016/j.cell.2006.09.026 . PMID 17081983 . {{ cite journal }}: Unknown parameter |name-list-format= ignored ( |name-list-style= suggested) ( help )

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000035203 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid9723620-4] ??? ^??? Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793?7. doi : 10.1038/29555 . PMID 9723620 .

[pmid10557078-5] Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene . 18 (43): 5915?22. doi : 10.1038/sj.onc.1202974 . PMID 10557078 .

[entrez-6] "Entrez Gene: EPN1 epsin 1" .

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