CXCR4

CXCR4
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	4RWS , 2K03 , 2K04 , 2K05 , 3ODU , 3OE0 , 3OE6 , 3OE8 , 3OE9 , 2N55
?????????????
??????? ????	CXCR4 , CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1
????????? ??????	OMIM: 162643 MGI: 109563 HomoloGene: 20739 GeneCards: CXCR4
?????? ?? (???)
????????	???????? ? (???)
?????	128,520,030 bp
????? ????? RNA
	; ; ; ;
	More reference expression data
?????????? ??
?????? ??????	? GO:0019974 cytokine binding ; ? coreceptor activity ; ? virus receptor activity ; ? signal transducer activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? chemokine receptor activity ; ? myosin light chain binding ; ? actin binding ; ? ubiquitin protein ligase binding ; ? G protein-coupled receptor activity ; ? C-X-C chemokine receptor activity ; ? ubiquitin binding ; ? C-C chemokine binding ; ? C-C chemokine receptor activity ; ? chemokine binding ; ? C-X-C motif chemokine 12 receptor activity ;
??????? ?????	? ????????? ; ? integral component of membrane ; ? ??????? ; ? membrane ; ? cell surface ; ? ????? ????????????? ; ? cell leading edge ; ? extracellular exosome ; ? GO:0016023 cytoplasmic vesicle ; ? early endosome ; ? late endosome ; ? ????????? ; ? ????? ????? ; ? external side of plasma membrane ; ? GO:0009327 protein-containing complex ; ? ???? ????? ;
?????? ?????	? myelin maintenance ; ? positive regulation of oligodendrocyte differentiation ; ? response to hypoxia ; ? positive regulation of cytosolic calcium ion concentration ; ? chemokine-mediated signaling pathway ; ? response to virus ; ? dendritic cell chemotaxis ; ? cellular response to cytokine stimulus ; ? ???????? ; ? inflammatory response ; ? calcium-mediated signaling ; ? GO:0072468 ???????? ???? ; ? GO:0097285 ??? ??????????????? ????? ; ? GO:0022415 viral process ; ? fusion of virus membrane with host plasma membrane ; ? regulation of chemotaxis ; ? G protein-coupled receptor signaling pathway ; ? ????? ??? ; ? GO:0046730? GO:0046737? GO:0046738? GO:0046736 ???? ????? ; ? brain development ; ? ???????? ; ? CXCL12-activated CXCR4 signaling pathway ; ? cell chemotaxis ; ? positive regulation of cold-induced thermogenesis ; ? regulation of cell adhesion ; ? neuron migration ; ? epithelial cell development ; ? neuron recognition ; ? response to activity ; ? ??? ????? ; ? telencephalon cell migration ; ? positive regulation of cell migration ; ? positive regulation of vascular wound healing ; ? regulation of programmed cell death ; ? response to morphine ; ? endothelial cell differentiation ; ? positive regulation of neurogenesis ; ? regulation of viral process ; ? positive regulation of chemotaxis ; ? detection of temperature stimulus involved in sensory perception of pain ; ? detection of mechanical stimulus involved in sensory perception of pain ; ? regulation of calcium ion transport ; ? cardiac muscle contraction ; ? endothelial tube morphogenesis ; ? positive regulation of dendrite extension ; ? positive regulation of mesenchymal stem cell migration ; ? response to ultrasound ;
	?????: ????? / ????????
?????????????
	7852
	12767
	ENSG00000121966
	ENSMUSG00000045382
	P61073
	P70658
	NM_001008540? NM_001348056? NM_001348059? NM_001348060? XM_047445802 NM_003467? NM_001008540? NM_001348056? NM_001348059? NM_001348060? XM_047445802
	XM_006529114? NM_001356509? XM_036157035 NM_009911? XM_006529114? NM_001356509? XM_036157035
	NP_003458? NP_001334985? NP_001334988? NP_001334989 NP_001008540? NP_003458? NP_001334985? NP_001334988? NP_001334989
	XP_006529177? NP_001343438? XP_036012928 NP_034041? XP_006529177? NP_001343438? XP_036012928
	?????????
??????/?????? ?????	??????/?????? ???

C-X-C chemokine receptor type 4 ( ??????? : ??????? ??? ? ?????? ??-????-?? ) ?? ≪ CD184 ≫? ?? ??????? ??? ?? ????? ???? ?? ≪ CXCR4 ≫ ??????? ??????. ^[?]^[?]

??? ??????? ???? ??????? ????- ?????? ??????? ???? ?????? ???????? SDF1 ??? ?? ????? ????????? ??? ?? ??? ?????????? ????. SDF1 ?????? ?? ?????????? ???????? ?????? ?????? ?? ??? ??????? ??? ???? ????. ??? ??????? ?????? ???? ??? CD20 ?? ?? ??????????? ?? ????? ??????. ^[?]

CXCR4 ??? ?? ??? ??????? ?????? ??? ?? ????? ???????? ??? ???????????? ??????????? ?? CD4+ ?? ???? ??????? ??????.

??????? ??????????? ??? ?????? ?????? ???????? ?????? ?????? ?? ??????? ???????.

???? ??? ?? ??????? ?????????? ?? ?????????????????? ???? CXCR4 ?? ?? ??? ??????????? ?? CD4+ ? CD8+ ?? ????? ???? ?????? ??????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology . 159 (9): 4322?9. PMID 9379028 .
↑ Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters . 426 (2): 271?8. doi : 10.1016/S0014-5793(98)00359-7 . PMID 9599023 .
↑ Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood . 128 : 1609?13. doi : 10.1182/blood-2016-04-709519 . PMID 27480113 .
↑ LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques" . Journal of Neuroimmune Pharmacology . 6 (4): 540?5. doi : 10.1007/s11481-011-9277-4 . PMC 3181271 . PMID 21484257 .

?????????????? ?????????. ≪ CXCR4 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ? ????? ????.

???? ??????? ????? [ ?????? ]

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??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid_9379028-4] Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology . 159 (9): 4322?9. PMID 9379028 .

[pmid_9599023-5] Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters . 426 (2): 271?8. doi : 10.1016/S0014-5793(98)00359-7 . PMID 9599023 .

[6] Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood . 128 : 1609?13. doi : 10.1182/blood-2016-04-709519 . PMID 27480113 .

[7] LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques" . Journal of Neuroimmune Pharmacology . 6 (4): 540?5. doi : 10.1007/s11481-011-9277-4 . PMC 3181271 . PMID 21484257 .

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