CLEC4A

CLEC4A
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	5B1W , 5B1X
?????????????
??????? ????	CLEC4A , CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
????????? ??????	OMIM: 605306 MGI: 1349412 HomoloGene: 49291 GeneCards: CLEC4A
?????? ?? (???)
????????	???????? ? (???)
?????	123,120,958 bp
????? ????? RNA
	; ;
	More reference expression data
?????????? ??
?????? ??????	? transmembrane signaling receptor activity ; ? carbohydrate binding ; ? calcium ion binding ; ? mannose binding ; ? metal ion binding ;
??????? ?????	? integral component of membrane ; ? ????? ????? ; ? integral component of plasma membrane ; ? membrane ;
?????? ?????	? cell surface receptor signaling pathway ; ? ??????? ????? ; ? stimulatory C-type lectin receptor signaling pathway ; ? adaptive immune response ; ? immune system process ; ? ?????? ????? ???? ; ? GO:0032697 negative regulation of cytokine production ; ? plasmacytoid dendritic cell antigen processing and presentation ; ? negative regulation of tumor necrosis factor production ; ? CD8-positive, alpha-beta T cell activation ; ? antigen processing and presentation of exogenous peptide antigen via MHC class I ;
	?????: ????? / ????????
?????????????
	50856
	26888
	ENSG00000111729
	ENSMUSG00000030148
	Q9UMR7
	Q9QZ15
	NM_016184? NM_194447? NM_194448? NM_194450? XM_017019382 XM_011520684? NM_016184? NM_194447? NM_194448? NM_194450? XM_017019382
	NM_001170333? NM_011999? XM_006506155? XM_011241364? XM_030255403 NM_001170332? NM_001170333? NM_011999? XM_006506155? XM_011241364? XM_030255403
	NP_919429? NP_919430? NP_919432? XP_011518986? XP_016874871? XP_024304765 NP_057268? NP_919429? NP_919430? NP_919432? XP_011518986? XP_016874871? XP_024304765
	NP_001163804? NP_036129? XP_006506218? XP_011239666? XP_030111263 NP_001163803? NP_001163804? NP_036129? XP_006506218? XP_011239666? XP_030111263
	?????????
??????/?????? ?????	??????/?????? ???

??? A ?? ???????? ? ??????? ????? ??? ?? ( ??????? : C-type lectin domain family 4 member A ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CLEC4A ≫ ???????? ??????. ^[?]^[?]

??????? ????? ??? ?? ????? ???????? ???? ??????????? ???? ????? ??? ?? ??? ?? ???? ?? ??????? ?????? ?????????? ????-??-????? ????? ? ??????? ???????????? ? ?????? ? ???? ????? ??? ?????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030148 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol . 163 (4): 1973?83. PMID 10438934 .
↑ "Entrez Gene: CLEC4A C-type lectin domain family 4, member A" .

?????????????? ?????????. ≪ CLEC4A ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol . 9 (5): 585?90. doi : 10.1016/S0959-440X(99)00009-3 . PMID 10508765 .
Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants". Biochem. Biophys. Res. Commun . 281 (1): 131?40. doi : 10.1006/bbrc.2001.4322 . PMID 11178971 .
Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation". J. Leukoc. Biol . 71 (5): 871?80. PMID 11994513 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins . 53 (1): 44?55. doi : 10.1002/prot.10440 . PMID 12945048 .
Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents". Biochem. Biophys. Res. Commun . 310 (3): 767?73. doi : 10.1016/j.bbrc.2003.09.077 . PMID 14550269 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2". Mol. Immunol . 43 (10): 1716?21. doi : 10.1016/j.molimm.2005.10.006 . PMID 16360206 .
Lorentzen JC, Flornes L, Eklow C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors". Arthritis Rheum . 56 (8): 2620?32. doi : 10.1002/art.22813 . PMID 17665455 .

????? ?? ????? [ ?????? ]

???? ???? CLEC4A ?????? ? ????? ?????? ??? CLEC4A ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030148 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10438934-4] Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol . 163 (4): 1973?83. PMID 10438934 .

[entrez-5] "Entrez Gene: CLEC4A C-type lectin domain family 4, member A" .

[?]

[?]

[?]

[?]

[?]