CLEC1B

CLEC1B
????????? ?????
PDB	?????? ?????????????: PDBe RCSB
????? ????????? PDB
	2C6U , 3WSR , 3WWK
?????????????
??????? ????	CLEC1B , 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
????????? ??????	OMIM: 606783 MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B
?????? ?? (???)
????????	???????? ? (???)
?????	129,386,298 bp
????? ????? RNA
	More reference expression data
?????????? ??
?????? ??????	? GO:0001948? GO:0016582 ????? ???????? ; ? carbohydrate binding ; ? transmembrane signaling receptor activity ;
??????? ?????	? integral component of membrane ; ? ????? ????? ; ? integral component of plasma membrane ; ? membrane ;
?????? ?????	? platelet activation ; ? defense response ; ? cell surface receptor signaling pathway ; ? ?????????? ; ? GO:0072468 ???????? ???? ;
	?????: ????? / ????????
?????????????
	51266
	56760
	ENSG00000165682
	ENSMUSG00000030159
	Q9P126
	Q9JL99
	NM_016509? XM_011520685? NM_001393342? XM_047428938 NM_001099431? NM_016509? XM_011520685? NM_001393342? XM_047428938
	NM_001204253? NM_019985 NM_001204239? NM_001204253? NM_019985
	NP_057593? XP_005253439? XP_011518987? XP_011518988? XP_016874884? XP_016874885 NP_001092901? NP_057593? XP_005253439? XP_011518987? XP_011518988? XP_016874884? XP_016874885
	NP_001191182? NP_064369 NP_001191168? NP_001191182? NP_064369
	?????????
??????/?????? ?????	??????/?????? ???

??? B ?? ???????? ? ??????? ????? ??? ?? ( ??????? : C-type lectin domain family 1 member B ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CLEC1B ≫ ???????? ??????. ^[?]^[?]^[?]

??? ?????? ??? ?? ?????????? ??? ????? ??? ?? ??? ?? ?? ??? ???????? ????? ????? ? ???????? ???????? ???? ??????.

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol . 30 (2): 697?704. doi : 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID 10671229 .
↑ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol . 31 (12): 3493?503. doi : 10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 . PMID 11745369 .
↑ "Entrez Gene: CLEC1B C-type lectin domain family 1, member B" .

?????????????? ?????????. ≪ CLEC1B ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

????? ?? ????? [ ?????? ]

???? ???? CLEC1B ?????? ? ????? ?????? ??? CLEC1B ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .
???? ???? CLEC2B ?????? ? ????? ?????? ??? CLEC2B ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

???? ??????? ????? [ ?????? ]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265?70. doi : 10.1101/gr.1293003 . PMC 403697 . PMID 12975309 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121?7. doi : 10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Suzuki-Inoue K, Fuller GL, Garcia A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood . 107 (2): 542?9. doi : 10.1182/blood-2005-05-1994 . PMID 16174766 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173?8. doi : 10.1038/nature04209 . PMID 16189514 .
Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2" . Acta Crystallographica Section F . 61 (Pt 12): 1094?6. doi : 10.1107/S1744309105037991 . PMC 1978148 . PMID 16511244 .
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature . 440 (7082): 346?51. doi : 10.1038/nature04569 . PMID 16541075 .
Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets" . J. Virol . 80 (18): 8951?60. doi : 10.1128/JVI.00136-06 . PMC 1563896 . PMID 16940507 .
Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem . 282 (5): 3165?72. doi : 10.1074/jbc.M610383200 . PMID 17132623 .
Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem . 282 (36): 25993?6001. doi : 10.1074/jbc.M702327200 . PMID 17616532 .
Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2" . Protein Science . 17 (9): 1611?6. doi : 10.1110/ps.035568.108 . PMC 2525532 . PMID 18583525 .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid10671229-4] Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol . 30 (2): 697?704. doi : 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID 10671229 .

[pmid11745369-5] Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol . 31 (12): 3493?503. doi : 10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 . PMID 11745369 .

[entrez-6] "Entrez Gene: CLEC1B C-type lectin domain family 1, member B" .

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