CELSR3

CELSR3
?????????????
??????? ????	CELSR3 , CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
????????? ??????	OMIM: 604264 MGI: 1858236 HomoloGene: 1077 GeneCards: CELSR3
?????? ?? (???)
????????	???????? ? (???)
?????	108,730,168 bp
?????????? ??
?????? ??????	? calcium ion binding ; ? G protein-coupled receptor activity ; ? signal transducer activity ; ? GO:0001948? GO:0016582 ????? ???????? ; ? transmembrane signaling receptor activity ;
??????? ?????	? integral component of membrane ; ? membrane ; ? ????? ????? ;
?????? ?????	? regulation of protein phosphorylation ; ? dopaminergic neuron axon guidance ; ? G protein-coupled receptor signaling pathway ; ? serotonergic neuron axon guidance ; ? neuron migration ; ? regulation of protein localization ; ? multicellular organism development ; ? Wnt signaling pathway, planar cell polarity pathway ; ? cell surface receptor signaling pathway ; ? ??????? ????? ; ? axonal fasciculation ; ? GO:0072468 ???????? ???? ; ? homophilic cell adhesion via plasma membrane adhesion molecules ; ? planar cell polarity pathway involved in axon guidance ; ? cilium assembly ; ? cell-cell adhesion ;
	?????: ????? / ????????
?????????????
	1951
	107934
	ENSG00000008300
	ENSMUSG00000023473
	Q9NYQ7
	Q91ZI0
	NM_001407
	XM_006511622? XM_006511623? XM_006511625? XM_006511626? XR_379754? XR_001778786? NM_001359572? NM_001359573? XR_004935302 NM_080437? XM_006511622? XM_006511623? XM_006511625? XM_006511626? XR_379754? XR_001778786? NM_001359572? NM_001359573? XR_004935302
	NP_001398
	XP_006511685? XP_006511686? XP_006511688? XP_006511689? NP_001346501? NP_001346502 NP_536685? XP_006511685? XP_006511686? XP_006511688? XP_006511689? NP_001346501? NP_001346502
	?????????
??????/?????? ?????	??????/?????? ???

???????? ??????? ??? ?????? ?????? ? ??? ?? ???? ?????? ??? ??????? ? ??????? ??? ?? ( ??????? : Cadherin EGF LAG seven-pass G-type receptor 3 ) ?? ??????? ??? ?? ?? ????? ???? ?? ≪ CELSR3 ≫ ???????? ??????. ^[?]^[?]

?????? ??? ??????? ??? ?? ??? ???? ???? ????????. ^[?]

????? [ ?????? ]

↑ ^??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000023473 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics . 51 (1): 27?34. doi : 10.1006/geno.1998.5341 . PMID 9693030 .
↑ ^??? ^??? "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)" .

?????????????? ?????????. ≪ CELSR3 ≫. ?? ????????? ?????????? ??????? ? ??????????? ?? ?? ?????? ????.

???? ??????? ????? [ ?????? ]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res . 6 (9): 791?806. doi : 10.1101/gr.6.9.791 . PMID 8889548 .
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell . 97 (6): 779?90. doi : 10.1016/S0092-8674(00)80789-8 . PMID 10380929 .
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3124?9. doi : 10.1073/pnas.060027397 . PMC 16203 . PMID 10716726 .
Formstone CJ, Barclay J, Rees M, Little PF (2000). "Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9". Mamm. Genome . 11 (5): 392?4. doi : 10.1007/s003350010073 . PMID 10790539 .
Nakayama M, Kikuno R, Ohara O (2003). "Protein?Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs" . Genome Res . 12 (11): 1773?84. doi : 10.1101/gr.406902 . PMC 187542 . PMID 12421765 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899?903. doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Bjarnadottir TK, Fredriksson R, Hoglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics . 84 (1): 23?33. doi : 10.1016/j.ygeno.2003.12.004 . PMID 15203201 .

????? ?? ????? [ ?????? ]

???? ???? CELSR3 ?????? ? ????? ?????? ??? CELSR3 ?? ?????? ?????? ???? ??? ??????? ?????????? ????? ???? .

??? ?? ?????? ??? ?????????? ??????? ???. ????????? ?? ????? ?? ?? ????????? ??? ????.

[refGRCm38Ensembl-1] ??? ^??? ^??? GRCm38: Ensembl release 89: ENSMUSG00000023473 - Ensembl , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[pmid9693030-4] Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics . 51 (1): 27?34. doi : 10.1006/geno.1998.5341 . PMID 9693030 .

[entrez-5] ??? ^??? "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)" .

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